Peptides: The Wave of the Future: Proceedings of the Second International and the Seventeenth American Peptide Symposium, June 9–14, 2001, San Diego, California, U.S.A.

Front Matter....Pages i-lxxi
From Merrifield to MetaPhore: A Random Walk with Serendipity....Pages 3-11
Genomics: From Microbes to Man....Pages 13-14
Front Matter....Pages 15-15
Fluorous Methods for Synthesis and Separation of Organic Molecules: From Separating Mixtures to Making Mixtures....Pages 17-19
Synthesis of β and γ-Substituted Prolines for Conformation-Activity Relationship Studies of the α-MSH Analogue MT-II....Pages 20-21
The General Asymmetric Synthesis of Syn - and Anti -β-substituted Cysteine and Serine Derivatives....Pages 22-23
The Novel Asymmetric Synthesis of β-Functionalized Phenylalanine Derivatives....Pages 24-25
An Efficient Method for Large-Scale Synthesis of Stereochemically Defined and Conformationally Constrained β-Substituted or α,β-Disubstituted Amino Acids....Pages 26-27
Synthesis of Amino Acids with Novel Biophysical Properties....Pages 28-29
Two Novel and Efficient Approaches to Synthesis of Enantiopure Dipeptide β-Turn Mimetics: Indolizidinone Amino Acids....Pages 30-31
Enantioselective Synthesis of β 2 -Homotryptophan for a Somatostatin Mimetic....Pages 32-33
Ethyl Nitroacetate as a Useful Synthon for the Synthesis of Orthogonally Protected, Poly-Functional C αα -Disubstituted Amino Acids....Pages 34-35
Synthesis of β-Benzo[ b ]thiophene Dehydroamino Acids by Suzuki Palladium Catalyzed Cross Coupling....Pages 36-37
Efficient Diastereoselective Synthesis of a Hydroxyethylene Dipeptide Isostere....Pages 38-39
One-Pot Conversion of Azides to Protected Guanidines via the Staudinger Reduction; Synthesis and Utilization of the Phe-Arg Hydroxyethylene Dipeptide Isostere....Pages 40-41
The Synthesis of Tyrosine Mimetics via a Novel N(1)-C(4) Beta-Lactam Cleavage Reaction....Pages 42-43
Michael Additions to Dehydroalanine Derivatives....Pages 44-45
Facile Synthesis of a Constrained Dipeptide Unit (DPU) for Use as a β-Sheet Promoter....Pages 46-47
Synthesis of N α -(Fluoren-9-ylmethoxycarbonyl)- N ε -[(7- methoxycoumarin-4-yl)-acetyl]-L-lysine for Use in Solid-Phase Synthesis of Fluorogenic Substrates....Pages 48-49
Preparation of β-Amino-α-mercapto Acids and Amides: Stereocontrolled Syntheses of 2′-Sulfur Analogues of the Taxol C-13 Side Chain, Both syn and and S -Acetyl- N -benzoyl-3-phenylisocysteine....Pages 50-51
New Approach for Preparation of C-Glycoamino Acid Building Blocks....Pages 52-53
Front Matter....Pages 15-15
New Quencher Derivatives for Fluorescence Quenching Peptide Assays....Pages 54-55
Preparation of (2 S )-2-Amino-3-(2-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-1 H -indol-3-yl)-propionic acid and Its Incorporation into Antibacterial Lactoferricin Peptides....Pages 56-57
UniChemo Protection (UCP)....Pages 58-60
An Improved Synthesis of Fmoc-Asp(O-3-methylpent-3-yl)-OH, an Aspartate Derivative That Resists Base Induced Aspartimide Formation....Pages 61-62
Systematic Investigation of the Aspartimide Problem....Pages 63-64
Ninhydrin as a Reversible Protecting Group of N-Terminal Cysteine....Pages 65-66
Novel Synthesis and Application of a Protected Bicyclic α-Helix-Initiating Heptapeptide Suitable for Segment Condensation Syntheses: Utility of Pentaaminecobalt(III) for Carboxyl Protection....Pages 67-68
N in -4-Nitrobenzenesulfonyl Tryptophan: A Convenient Preparation of N α -Boc and N α -Fmoc Derivatives....Pages 69-70
Syntheses of Difficult Hydrophobic Sequences Using 2-(4-Nitrophenyl)sulfonylethoxycarbonyl(Nsc)- N α -(2-hydroxy- 4-methoxybenzyl)Ala-OH: (Ala) 10 -Valine, (Ala) 15 -Valine....Pages 71-72
A Highly Efficient Method for Synthesis of Fmoc-Lysine(Mmt)-OH....Pages 73-74
A New Practical Approach to the Synthesis of Fmoc-L-Cysteine....Pages 75-76
A Novel Protocol of Solid Phase Peptide Synthesis with 2-(4-Nitrophenyl)sulfonylethoxycarbonyl(Nsc)-Amino Acids....Pages 77-78
 S -Xanthenyl Protected 1-Thiosugars as Building Blocks for Glycopeptide Assembly....Pages 79-80
Late Deprotection Difficulties During SPPS Depend on the Preceding Sequence....Pages 81-82
Towards a Selective Boc Deprotection on Acid Cleavable Resin....Pages 83-84
By-Product Formation During SPPS of Linear, Cyclic, and Novel Bicyclic Peptides as AChE Inhibitors....Pages 85-86
Acidic Cleavage of the Side Chain Protecting Groups of Peptides Attached to a Modified Polystyrene Carrier: Synthesis of Peptide Generics....Pages 87-88
The Use of a Novel Safety Catch Linker for BOC-Based Assembly of Cyclic Peptide Libraries....Pages 89-90
Diurethanyl 1 H -Benzotriazole-1-carboxamidines as Guanidinylating Reagents....Pages 91-92
Amino Acid Bromides: A Convenient Choice for Very Difficult Couplings....Pages 93-94
Front Matter....Pages 15-15
Synthesis of the Two Isomeric Benzo Derivatives of 1-Hydroxy-7-azabenzotriazole and Preliminary Studies of Their Effectiveness as Coupling Reagents....Pages 95-96
Optimization of Coupling Methods for the Introduction of Mono-Benzyl Phosphate Esters of Fmoc Protected Phosphoamino Acids....Pages 97-98
HATU-HOAt-CuCl 2 : A Reliable Racemization-Free Segment Coupling System....Pages 99-100
Search for a Safe, Inexpensive and Convenient Amidation Process for Protected Amino Acids and/or Peptides....Pages 101-102
Extending Synthetic Access to Proteins....Pages 103-104
A New Scaffold for Amide Ligation....Pages 105-106
Chemical Ligation of Multiple Peptide Fragments Using a New Protection Strategy....Pages 107-108
Synthesis of Oligodeoxynucleotide-Peptide Conjugates Using Hydrazone Chemical Ligation....Pages 109-110
The Use of a Free Peptide for Preparation of a C-Terminal Building Block for Polypeptide Synthesis in Combination with a Peptide Thioester....Pages 111-112
Synthesis of N to C Terminal Cyclic Analogues of α-Conotoxin Iml by Chemoselective Ligation of Unprotected Linear Precursors....Pages 113-114
Total Chemical Synthesis of κ-Casein Using Native Ligation Methodology....Pages 115-116
Fmoc Chemistry Compatible Methods for Thio-Ligation Assembly of Proteins....Pages 117-118
Simultaneous Lipidation of a Multi-Epitope Peptide Cocktail by Chemoselective Hydrazone Formation....Pages 119-121
Privilege Structures: New Strategies for the Synthesis of Cyclic Tetrapeptides....Pages 122-124
Incorporation of a cis-Amide Bond Isostere in the Synthesis of Cyclic Tetrapeptides....Pages 125-126
Covalent Control of Shape and Folding in Peptides by Ring-Closing Metathesis....Pages 127-129
New Synthetic Routes to NEtXaa 4 -Cyclosporin Derivatives as Potential Anti-HIV Drugs....Pages 130-131
Transition Metal Complexes of Linear and Cyclic Pseudopeptides....Pages 132-133
An Efficient Synthesis of Integrin Antagonists cyclo (-RGDfK-), cyclo(-GRGDfK-) and Their Conjugates with MAG3 Chelate....Pages 134-135
Design and Synthesis of Cyclic Peptide Antagonists Intended to Block Coactivator Binding to Steroid Nuclear Receptors....Pages 136-137
Front Matter....Pages 15-15
A Novel Design and Synthesis of Bicyclic Peptide Library....Pages 138-139
Strategies for the Synthesis of Cyclic Peptides....Pages 140-141
Vinyl Sulfide Cyclized Analogues of Angiotensin II with High Affinity to the AT 1 -Receptor....Pages 142-143
Strategies for the Synthesis of Novel Head-to-Side Chain Cyclic Peptides: Application to Dynorphin A Analogs....Pages 144-145
Study on the Influence of Different Metal Ions on Cyclization of Linear Pentapeptides and Heptapeptide....Pages 146-147
Disulfide Bond Formation of a Hydrophobic Peptide by Dimethyl Sulfoxide....Pages 148-149
Stereoselective Synthesis of Transition State Analog Inhibitors of DPP-IV Using 2-Substituted Thiazoles....Pages 150-151
Original and General Strategy of Dimerization of Bioactive Molecules....Pages 152-154
An Efficient Approach for the Synthesis of Salmon Calcitonin Using Oxazolidine Dipeptides....Pages 155-156
A Combined Solid-Phase and Solution Strategy for Chemical Synthesis of Human Leptin....Pages 157-159
Synthesis of Phosphorylated Polypeptide by the Thioester Method Using a Recombinant Protein....Pages 160-161
The Synthesis of the K- Ras -Derived Peptide....Pages 162-163
Synthesis of Phosphopeptides on Solid Phase Using tert -Butyl- H -phosphonate Salts....Pages 164-165
Solid Phase Synthesis of Seleno-Methionine Peptides by tBoc/Bzl and Fmoc/tBu Protection Strategy Suitable for the Crystallographic Phase Determination by Multi-Wavelength Anomalous Diffraction (MAD)....Pages 166-167
Synthesis of a C-Terminal Fluorescein-Labeled 36-mer Peptide....Pages 168-169
Expanding Diversity: Modification of Linear and Cyclic Peptides by C-Glycosylation and N-Methylation....Pages 170-171
One-Dimensional Spatial Encoding: Split/Mix Synthetic Parallelism with Tag-Free Identification and Assays at the Speed of Light....Pages 172-173
Spatial Screening of Lectin Ligands. Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates....Pages 174-176
Combinatorial Syntheses of Polyhydroxamate Siderophores: Desferrioxamine, Exochelin, Mycobactin, and Aerobactin Libraries....Pages 177-179
Identification of Peptide Ligands for α4β1 Integrin Receptor as Potential Targeting Agents for Non-Hodgkin’s Lymphoma....Pages 180-182
Front Matter....Pages 15-15
Development of Peptidomimetic Substrates and Inhibitors that Bind to the Peptide Binding Pocket of the Catalytic Site of p60 c-src Protein Tyrosine Kinase....Pages 183-184
Pseudoproline Libraries for Tuning Inhibitors of SH3 Domain Mediated Protein-Protein Interactions....Pages 185-186
Towards a Set of Peptides with Orthogonal HIV Seroreactivity Using Adaptively Coded Peptide Libraries: Decoding by Mass Spectrometry and Immunofluorescent Screening....Pages 187-188
Mapping of Discontinuous Epitopes on FSH....Pages 189-190
Development of Highly Specific, Membrane Permeable Peptide Blockers of cGMP-Dependent Protein Kinase Utilizing Affinity Selection from Peptide Libraries....Pages 191-193
The Integration of Positional Scanning Libraries with Bioinformatics and Proteomics....Pages 194-195
Screening and Synthesis of a Positional Scanning Library Based on the Bowman-Birk Reactive Site Loop....Pages 196-197
A Bicyclic Peptide Template Useful for Solution-Phase Combinatorial Synthesis....Pages 198-199
Synthesis of Combinatorial Libraries Associated with Constrained β-Turn Mimetics....Pages 200-201
Screening and Design of Hybrid Peptide That Binds with Glucose Oxidase....Pages 202-203
Combinatorial Synthesis, Screening and Testing of Peptidic RNA-Ligands....Pages 204-205
High Throughput Peptide Syntheses Generate Ligands for Proteomic Database....Pages 206-207
MHC Ligand Motifs from Peptide Libraries: The Software EPIPREDICT....Pages 208-209
High-Density Compound Arrays of Combinatorial Chemical Libraries by a New Pen-Directed and Computer-Navigated Plotter Device....Pages 210-211
Combining SPOT Synthesis and Native Chemical Ligation to Generate Large Arrays of Small Protein Domains....Pages 212-213
Peptides as Drugs: Is There a Market?....Pages 214-216
Solid-Phase Total Syntheses of Trunkamide A and Kahalalide F, Cyclic Peptides from Marine Origin....Pages 217-219
Solid Phase Synthesis of Large Cyclic Peptides....Pages 220-221
Solid-Phase Synthesis of Consolidated Ligands Containing an Intramolecular Lactam Bridge: Comparison of Strategies and Tactics....Pages 222-223
Backbone Amide Linker (BAL)/Fmoc Synthesis of Peptide Thioester Intermediates Required for Native Chemical Ligation....Pages 224-225
Front Matter....Pages 15-15
Ampullosporin Analogs: Solid Phase Synthesis, Conformational Studies, and Biological Activities....Pages 226-227
Synthesis of Lanthionine-Containing Peptides on Solid Phase via an Orthogonal Protecting Group Strategy....Pages 228-229
Systematic Solid Phase Synthesis of Linear Pseudooligolysines Containing Multiple Adjacent CH 2 NH Amide Bond Surrogates: Potential Agents for Gene Delivery....Pages 230-231
Peptide Transformation and Synthesis of Oligopeptidomimetics....Pages 232-233
A New Strategy for Inverse Solid-Phase Peptide Synthesis....Pages 234-235
Optimization of the Chemical Synthesis of Human Ghrelin....Pages 236-237
Rational Design and Synthesis of a Potent Amide-Linked Cyclic Analogue of MBP87–99 Based on 2D-NMR Studies and Molecular Dynamics....Pages 238-239
Solid-Phase Synthesis Utilizing Azido-α-Amino Acids: Reduction of Azido-Protected Proline....Pages 240-241
Improved Fmoc-Solid Phase Synthesis of β-Amyloid Peptides Using DBU as N α -Deprotection Reagent....Pages 242-243
Triphosgene as Peptide Coupling Reagent: Highly Efficient Total Synthesis of Cyclosporin O....Pages 244-245
Synthesis of Ferrocene Linkers for Solid-Phase Synthesis of Peptides....Pages 246-247
Efficient HF Conditions for Suppressing Trp Modification Associated with Use of the N in -Cyclohexyloxycarbonyl (Hoc) Group....Pages 248-249
Structural Characterization of a Dibenzylated-CGRP(8–37), a Byproduct from N -α-Benzylation of CGRP(8–37)....Pages 250-251
Polyamines as Intermediates for the Synthesis of Heterocyclic Compounds and Oligomeric Heterocyclic Compounds from Resin-Bound Polyamides....Pages 252-254
Solid-Phase Synthesis of Substituted Dihydroimidazoles and Their Bis Analogs....Pages 255-256
Solid Phase Synthesis of 1,2,5-Substituted Derivatives of 4-Imidazolidinone....Pages 257-258
Solid Phase Synthesis of 1,2,4-Triazinan-3-ones....Pages 259-260
Solid-Phase Synthesis of α-Difluoro-β-amino Acids by a Reformatsky Reaction....Pages 261-262
Peptidotriazoles: Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions on Solid-Phase....Pages 263-264
Solid-Phase Synthesis of Lidocaine Analogues Using Backbone Amide Linker (BAL) Anchoring....Pages 265-266
Front Matter....Pages 15-15
Solid-Supported Triazenes as Alkylating Polymers Employed for the Versatile Derivatization of Peptides....Pages 267-268
Oxidation of Threonine and Serine Residues on Solid-Phase: Pyrazine Formation by Dess-Martin Periodinane Oxidation....Pages 269-270
A Novel Solid Phase Approach to Thioether Cyclized Peptides: Discovery of Mouse Melanocortin-1 Receptor Agonists....Pages 271-272
Bifurcated Dipeptide Schiff Bases as Ligands for Enantioselective Catalysis: Micro-Metalloenzymes....Pages 273-274
Recent Advances in the Solid-Phase Synthesis of Long-Chain β-Peptides....Pages 275-276
Fully Automated Parallel Oligonucleotide Synthesizer....Pages 277-278
 N to C Solid Phase Organic Synthesis of Peptidic and Peptidomimetic Derivatives Using 9-Fluorenylmethyl Esters....Pages 279-280
Front Matter....Pages 281-281
A New Method to Quantify the Swelling Properties of Polymer Beads Used in Solid Phase Peptide Synthesis (SPPS)....Pages 283-284
A Novel High Throughput Analysis of Total Nitrogen Content by a Colorimetric Method....Pages 285-286
Conformational Studies of Cyclotetrapeptides [Xaa-D-Ala] 2 by NMR, CD and Molecular Modeling....Pages 287-288
Conformation of β 3 -Residues-Containing Cyclic Pentapeptide Analogues of the Antitumoral Astin Family....Pages 289-290
Structure-Activity Relationship of Antimicrobial Peptide, Gaegurin 4, Isolated from Korean Frog....Pages 291-292
Tethering of the Proximal Region of the Angiotensin II Receptor (AT 1A ) C-Terminus to the Cell Membrane....Pages 293-294
Amide I Frequency as a Probe of Tertiary Structure: FTIR Studies of Helix Bundle Peptides....Pages 295-296
Coupled Plasmon Waveguide Resonance Studies of Agonist/Antagonist Binding to the Human δ-Opioid Receptor Provide New Structural Insights Into the Three-State Model for Receptor-Ligand Interactions....Pages 297-298
Structure Elucidation of Peptides with Unnatural Amino Acids Using an Automated Protein Sequencer....Pages 299-300
Structural Study of the Pro-Sequence of Protegrin-3....Pages 301-302
α-Helix Stabilizing Aromatic-Backbone Interactions....Pages 303-305
Solution Structure of Oligopeptides-Copper(II) Complexes....Pages 306-307
Development of Antibodies Against Conjugated Benzophenone, as a Tool in Photoaffinity Crosslinking Studies....Pages 308-309
Front Matter....Pages 281-281
Monitoring Peptide-Induced Liposome Breakdown with Fluorescence Correlation Spectroscopy....Pages 310-311
NMR Structural Investigation of a β 3 -Dodecapeptide with Proteinogenic Side Chains in MeOH and Water....Pages 312-313
Conformational Studies on a Synthetic Peptide with Prolactin-Releasing Activity in a Membrane Mimetic Environment....Pages 314-315
Analysis and Characterization of Combinatorial Mixtures of Mucin-2 Antigen Peptides....Pages 316-317
High Throughput Validation and Quantitation of Synthetic Peptides via LC-MS....Pages 318-319
Synthesis and Solution Three-Dimensional Structure of the Immunodominant Region of Protein G of Human RSV....Pages 320-321
Role of Residues in Position 2 and 7 on the Conformation of the N-Terminal Apamin Loop....Pages 322-323
Conformational Study of [desHis 1 , desPhe 6 , Glu 9 ]glucagon-NH 2 by 2D-NMR Spectroscopy in the Presence of Perdeuterated Dodecylphosphocholine....Pages 324-325
Molecular Modeling Study of the β-Turn-Type Reversals Involved in 3D Structure of IFABP....Pages 326-327
Structural Features of Short, Linear Peptides in Solution by Fluorescence and Molecular Mechanics Studies....Pages 328-329
Influence of Stereochemistry of the Preceding Acyl Residue on the cis/trans Ratio of the Proline Peptide Bond....Pages 330-331
The Influence of the Surrounding Media on the Structural Propensities of Amino Acid Residues in Proteins....Pages 332-333
CD Evidence of the Conformational Transitions in rMOG[1–125] in the Presence of Membrane Mimicking Detergents....Pages 334-335
Coacervation and CD and FT-IR Spectroscopic Studies of Elastin-Derived Polypentapeptide and Its Analogs....Pages 336-337
Conformational Analysis of Human Calcitonin in Aqueous Solution and Comparison with a Highly Potent Lactam-Bridged Analogue....Pages 338-339
Conformational Studies of a Glycopeptide Recognized with High Affinity by Autoantibodies in Multiple Sclerosis....Pages 340-341
Human Relaxin Chain Combination and Folding....Pages 342-343
Effects of Human Leptin Fragments in Hypothalamic Nucleus C-Fos Expression....Pages 344-345
Introduction of Temperature-Sensitive Elastin-Based Switches to Stabilize Globular Proteins....Pages 346-347
A Short-Range Interaction of the cis-trans Urea Motif in Ureapeptides....Pages 348-349
Front Matter....Pages 281-281
A New N-Terminal Helix Capping Box....Pages 350-352
The Determination of Helix Stability Coefficients Using D-Amino Acid Substitutions in the non-Polar Face of an Amphipathic α-Helical Model Peptide....Pages 353-354
NMR-Based Studies of a Collagenous Substrate of Collagenase....Pages 355-356
Conformational Analysis of Model Polypeptides Having Repetitive Xaa-Pro Sequences....Pages 357-358
The Role of Unstructured Highly Charged Regions on the Stability and Specificity of Dimerization of Two-Stranded α-Helical Coiled-Coils: Neck Region of Kinesin-Like Motor Protein Kif3A....Pages 359-360
A Leu-Thr-Trp-Lys “Lock” Stabilizes the N-Terminus of the Kinesin Neck Coiled-Coil....Pages 361-362
Template-Assisted Stabilization of a Short HIV-1 gp41 Inner-Core Coiled-Coil Peptide....Pages 363-364
STABLECOIL: An Algorithm Designed to Predict the Location and Relative Stability of Coiled-Coils in Native Protein Sequences....Pages 365-366
Stabilization of Helical Conformation in Model Peptides by 2,2,2-Trifluoroethanol: An FTIR Study....Pages 367-368
Peptides Based on Daf, the First Rigid, Transition-Metal Receptor: C α,α -Disubstituted Glycine....Pages 369-370
Allyl-Based, C α -Methylated α-Amino Acids in the Side-Chain to Side-Chain Ring-Closing Metathesis Reaction of β-Turn/3 10 -Helical Peptides....Pages 371-372
Synthesis and Conformational Analysis of Polypeptides Having Repetitive Xaa-Pro-Pro Sequences....Pages 373-374
Biophysical Studies of a Proline-Rich Peptide from the Coral Bleach Pathogen Vibrio shiloi ....Pages 375-376
Lactam-Bridged and Disulfide-Bridged Peptide Mimic of a Stable α-Helical Folded Protein....Pages 377-378
Stabilization of the Triple Helix of Collagen Peptides Using Fluoroproline and/or Triacid Scaffolds....Pages 379-380
Conformational Studies of O-Glycosylated 15-Residue Peptide from the Human Mucin (MUC1) Protein Core....Pages 381-382
Folding of β- and γ-Peptides — the Influence of Substitution Patterns on the Formation of Secondary Structures....Pages 383-384
The β-Methyne of Ile3 in the Propeptide Region of Prouroguanylin is Crucial for Chaperone Function in the Folding of the Mature Peptide, Uroguanylin....Pages 385-386
Solution Structure of the Macrocyclic Squash Trypsin Inhibitor MCoTI-II, the First Member of a New Family of Cyclic Knottins....Pages 387-388
Delineation of Structural Constraints Imposed by a Dimerizer Peptide When Grafted Onto the Terminal Ends of a Test Peptide....Pages 389-390
Front Matter....Pages 281-281
Local and Long-Range Sequence Contributions to the Folding of a Predominantly β-Sheet Protein....Pages 391-393
3D Models for Conformational States of the V3 and V1/V2 Loops in gpl20/CD4/Antibody Complex....Pages 394-395
Structure and Dynamics of Ribosome Recycling Factor....Pages 396-397
Peptide Models for Studying Autonomous Folding of Subdomain Sections of Protein Molecules....Pages 398-399
Towards New Designed Proteins: Oxime Ligation of Core Modules....Pages 400-401
Do Bioactive Peptides Display Native-Like Conformations When Bound to a Solid Support?....Pages 402-403
Direct Observation of Backbone Hydrogen Bonding in the Folding Transition of Chymotrypsin Inhibitor 2 (CI2)....Pages 404-405
Optimizing Aqueous Fold Stability for Short Polypeptides: 20 Residue Miniprotein Constructs That Melt as High as at 61 °C....Pages 406-408
Synthetic Approach to Study the Effects of β-Turn Residues on the Structure and Folding of Bovine Pancreatic Trypsin Inhibitor (BPTI)....Pages 409-410
NMR Solution Structure of B-Motif, a Signature Motif of Type-B Response Regulators for His-to-Asp Phosphorelay Signal Transduction System, and Its Interactions with DNA....Pages 411-412
Synthesis and Characterization of the Pain-Killing Peptide Grammostola spatulata Analgesic Factor (GsAF-1) Containing Three Disulfide Bonds....Pages 413-414
Molecular Modeling: Indispensable Tool at the Interface Between Structural Analysis and Molecular Design....Pages 415-417
Molecular Modeling and Binding Energy Calculations for Drug Resistant Mutations in HIV-1 Protease-Inhibitor Complexes....Pages 418-419
Electrostatic and Hydrophobic Nature of the Binding of Gelsolin 135–142 and Gelsolin 150–169 Fragments to the PIP2-Containing Lipid Bilayer....Pages 420-421
Prediction of Antibody Complexes with Rationally-Designed and Library-Derived Cyclic Peptides: A Computer Modeling Study....Pages 422-423
Ligand-Receptor Interactions Regulating Cell Trafficking and Signaling of the Human PTH1Rc: An in Silica Examination....Pages 424-425
Theoretical Design of α-Hairpin Structures....Pages 426-427
Application of a Detailed Energy Surface to Homology Modeling of the ω-Conotoxin Family....Pages 428-429
DARWINIZER® — a Computer Based Method for Peptide and Peptidomimetics Design....Pages 430-431
Proline: A Key Building Block in “de novo” Designed Peptide Molecules....Pages 432-434
Front Matter....Pages 281-281
Complementary Assembly of Heterogeneous Multiple Peptides into Amyloid Fibrils with α-β Structural Transitions....Pages 435-437
Conformational Uniqueness via Designed Ion Pairs....Pages 438-439
Design, Synthesis and Incorporation in Peptides of a β-Turn Mimetic....Pages 440-441
Evaluating PERMs as Protein Mimics....Pages 442-443
Amphipathic Stabilization of the 3 10 -/α-Helix Equilibrium in Synthetic Peptides Rich in C α , C α -Disubstituted Glycines....Pages 444-445
Design, Synthesis and Characterization of Novel Scaffold-Assembled Collagen Mimetics....Pages 446-447
Design and Synthesis of a Mini-Prorelaxin Model....Pages 448-449
Site Specificity Metal Binding Affinity in C-Terminal of Calmodulin....Pages 450-451
A Cassette Ribonuclease: Site Selective Cleavage of RNA by a Ribonuclease S-Bearing RNA-Recognition Segment....Pages 452-453
Protein Models on Carbohydrate Templates: Effect of the Template....Pages 454-455
New Foldamers: Rigid Peptides with an Alternating cis-trans Amide Sequence....Pages 456-457
Design, Synthesis, and Conformational Studies of Short Peptides Containing C αα -Dipropylglycine and Dibenzylglycine....Pages 458-459
Bromo Tryptophan Based Antisickling Peptides: Design, Synthesis and Evaluation....Pages 460-461
Synthesis, Redox and Structural Properties of Cystine-Cyclopeptides Containing the Active-Site of the Thioredoxin Superfamily....Pages 462-463
Probing Backbone Flexibility Within the Active Site of Glutaredoxin 3....Pages 464-465
Homostranded and Heterostranded α-Helical Templates for Combinatorial Library Display: Differences in Stability and Solubility....Pages 466-467
Synthesis and Solution Structures of Cyclic Hexapeptides Cyclo(Pro-Leu-Xxx) 2 ....Pages 468-469
Functional and Structural Comparisons of Linear and Dendritic Arrays of Polypeptides....Pages 470-471
Front Matter....Pages 473-473
Synthetic Studies on the Antimicrobial Activity of Pleurocidin....Pages 475-476
Disruption of the β-Sheet Structure of Cyclic Peptides by Single Amino Acid Substitution: Influence on Prokaryotic and Eukaryotic Cell Viability....Pages 477-478
Front Matter....Pages 473-473
Relationship Between Amphipathic Secondary Structure and Activity in Model Linear Cationic Antimicrobial Peptides....Pages 479-480
Shedding Light on the Aglycon Formation of Glycopeptide Antibiotics....Pages 481-482
Synthesis of λ-Conotoxins, a New Family of Conotoxins with Unique Disulfide Pattern....Pages 483-484
Solution Conformation of an α-Conotoxin GI with a D-Tyr at Position 11....Pages 485-486
Antimicrobial and Chemotactic Activities of ω-Conotoxin Cyclic Analogues....Pages 487-488
Synthesis of Parallel and Antiparallel Magainin 2 Dimers and Their Interaction with Lipid and Cell Membrane....Pages 489-490
Interaction of the Antimicrobial Peptide PGLa and Its Ala-Substitution Analog with Membrane-Mimetic Systems....Pages 491-492
Antibacterial Activity Spectrum of Designed Pyrrhocoricin Analogs....Pages 493-494
Importance of the Intramolecular Disulfide Bridges in the Biological Activity of Gomesin....Pages 495-496
Variation in Ring Size of Cyclic Antimicrobial Peptides Results in Diversity and Selectivity of Biological Activity....Pages 497-498
α-Helical Glycopeptide Analgesics: β-Endorphin Mimics with Good in vivo Potency....Pages 499-501
Efforts to Investigate the Conformational Changes of the Prion Protein by N-Glycosylation....Pages 502-503
Glycation of Leucine-Enkephalin: Imidazolidinones and Amadori Compounds....Pages 504-505
Solid-Phase Synthesis of Thio-Linked C-Terminal Glycopeptides via a Mitsunobu Reaction....Pages 506-507
Synthesis of the Extracellular Ig Domain I (34–94) of Emmprin Carrying a Chitobiose Unit....Pages 508-509
Synthesis of Peptide- and Glycopeptide-Conjugates for Specific Drug Targeting....Pages 510-511
Complexation of Peptidoglycan Intermediates by the Lipoglycodepsipeptide Antibiotic Ramoplanin: Structural Requirements for Intermolecular Complexation and Fibril Formation....Pages 512-513
Short Analogues of the Lipopeptaibol Trichogin GA IV....Pages 514-515
Dinuclear Zinc(II) Complexes of Linear and Cyclic Peptides Containing Two Bis(2-pyridylmethyl)amino Groups as Catalysts for Hydrolysis of RNA Model Substrate....Pages 516-517
Construction of RNA-Binding Proteins Having Nucleobase Amino Acids Based on HIV-1 Nucleocapsid Protein....Pages 518-519
Front Matter....Pages 473-473
Screening of Peptides that Control Interaction Between Nucleobases from Peptide Libraries Based on Loop Structures....Pages 520-521
Preparation of a Site-Specifically Labeled Fluorescent Chemokine by Chemical Synthesis....Pages 522-523
Synthesis, Characterization, and Calorimetric Studies of a Series of Novel Bioconjugates for Selective Targeting of Microbubbles to GPIIbIIIa Receptors on Vascular Thrombi....Pages 524-525
Energy and Electron Transfer Systems Built in Dendritic Poly(L-lysine)s....Pages 526-527
Design of Analogs of Trapoxin, Cyl-1, and Chlamydocin for MHC Class-I Molecule Up-Regulation....Pages 528-529
Backbone Assignment of Gyrase-B P24 Fragment and Its Interactions with the Inhibitor GR122222....Pages 530-531
Synthetic Progress Towards a TMC-95 Analogue as a Potential Proteasome Inhibitor....Pages 532-533
Prime Site Binding Inhibitors of the Hepatitis C Virus NS3/4A Serine Protease....Pages 534-536
Solution and Solid Phase Synthesis of Non-Peptide Peptidomimetic Aspartic Peptidase Inhibitors....Pages 537-538
Design and Synthesis of Novel Matrix Metalloproteinase Inhibitors....Pages 539-540
A Novel Continuous Assay for the Mechanistic Characterization of Histone Deacetylases and Homologues Using a Small Molecule Fluorescent Substrate....Pages 541-542
Peptide Inhibitors of α-Amylase Based on Tendamistat: Synthesis and Kinetic Studies....Pages 543-544
Structural Studies of the Complex Between Decapeptide Inhibitors and the Serine Protease NS3/4A of Hepatitis C Virus....Pages 545-546
Synthesis and Activity of a Small Cyclic Protease Inhibitor from Sunflower Seeds, SFTI-1....Pages 547-548
Different Types of P1 Residues in Peptide-Based Inhibitors of Hepatitis C Virus Full-Length NS3 Protease....Pages 549-550
Development and Characterization of Potent Peptide Inhibitors of p60 c-src PTK Using Pseudosubstrate-Based Inhibitor Design Approach....Pages 551-552
Use of β-Amino Acids in the Design of Substrate-Based Peptidase Inhibitors....Pages 553-554
Bivalent Inhibition of Human β-Tryptase: Probing the Distance Between Neighbouring Subunits by Dibasic Inhibitors....Pages 555-557
A Highly Selective Cell Permeable Peptide Inhibitor of Proprotein Convertase 1: Design, Synthesis and Biological Evaluation in Cellular PC1-Mediated Proteolysis....Pages 558-560
Bicyclic Peptide Inhibitors of an Epithelial Cell-Derived Transmembrane Protease, Matriptase....Pages 561-562
Front Matter....Pages 473-473
Probing the Substrate Specificity of Hepatitis C Virus Nonstructural 3 Protein Serine Protease by Intramolecularly Quenched Fluorogenic Peptide Substrates....Pages 563-564
Characterization of the Staphylococcus aureus Sortase Transpeptidase: A Novel Target for the Development of Chemotherapeutics Against Gram-Positive Bacteria....Pages 565-566
Cyclic Octapeptide Inhibitors of the Acetylcholinesterase Peripheral Site: Implications for Inhibition of Nerve Toxins....Pages 567-568
Homologs of Amino Acids and Explorations into the Worlds of β- and γ-Peptides....Pages 569-571
Designed Amino Acids That Induce β-Sheet Folding and β-Sheet Interactions in Peptides....Pages 572-574
Triply-Templated Artificial β-Sheets....Pages 575-576
Stepwise Peptide-Peptoid Transformation via SPOT Synthesis....Pages 577-578
SPOT Synthesis of 1,3,5-Trisubstituted Hydantoins on Cellulose Membranes....Pages 579-580
Synthesis and CD Spectra of β 2 -(3-Aza-peptides)....Pages 581-582
Preferred Conformations of Azaamino Acids....Pages 583-584
Higher Anti-HIV-1 Activity of Peptides Derived from gp41 Carboxyl-Terminal Coiled Coil Structure of HIV-1 89.6 Strain....Pages 585-586
Synthetic Approach to Dipeptide Mimetics Based on Aminoacyl Incorporation Reaction....Pages 587-588
Convenient Conversion of Amino Acids to Their N -Hydroxylated Derivatives on a Solid Support: Synthesis of Hydroxamate-Based Pseudo-Peptides....Pages 589-590
Peptide Bond Modification for Metal Coordination: 1. Metal-Binding Properties of Hydroxamate-Based Pseudo-Peptides....Pages 591-592
Peptide Bond Modification for Metal Coordination: 2. Metal-Binding Properties of Peptide-Derived Pentaaza-Macrocyclic Templates....Pages 593-594
Peptide Bond Modification for Metal Coordination: 3. Metal-Binding Properties of Phosphorus-Based Pseudo-peptides....Pages 595-596
Mimicry of the Backbone and Side-Chain Geometry of Peptide Turns: Synthesis of Novel 4-Substituted Indolizidin-9-one Amino Acids....Pages 597-598
Employing the Steric Interactions of 5- tert -Butylproline to Control Peptide Folding and Biology....Pages 599-601
Synthesis of β-Turn Mimetics: [5,5]-Fused Bicyclic γ-Lactam Dipeptide Analogues....Pages 602-603
Pyridine as a Tripeptidomimetic Scaffold....Pages 604-605
Front Matter....Pages 473-473
Synthesis of Fluoroalkene Dipeptide Isosteres Utilizing Organometallic Reagents....Pages 606-607
Synthesis of Peptide Mimetics and Amino Acid Mimetics Bearing Aminoxy Instead of Amino Group....Pages 608-609
Design and Synthesis of Amide Isosteres of Phe-Gly: Potential Peptidomimetic Ligands for the Intestinal Oligopeptide Transporter PepT1....Pages 610-611
β-D-Mannose Based Peptidomimetics in the Design of α 4 ß 1 and α 4 β 7 Antagonists....Pages 612-613
Design, Synthesis and Modulation of Angiogenesis by Thrombin Receptor Non-Peptide Antagonists....Pages 614-615
Development of Endomorphin Derivatives with Dual Functions and Studies on Their Three-Dimensional Structure....Pages 616-617
Stereoselective Synthesis of Tyrψ[CH 2 O]Phe and Tyrψ[CH 2 O]Ile, Methylene-oxy Analogs of Oxytocin and [8-Arginine]Vasopressin....Pages 618-619
Exploration of the DTrp-NMeLys Motif in the Search for Potent Somatostatin Antagonists....Pages 620-621
Synthesis and Biological Evaluation of Mixed β 2 /β 3 -Dipeptides as Somatostatin Analogs....Pages 622-623
Cyclic Peptides Related to Somatostatin Containing a Novel Imidazole Derived cis -Amide Mimetic....Pages 624-625
Human Somatostatin Receptor Specificity of Backbone-Cyclic Analogs Containing Novel Sulfur Building Units....Pages 626-627
Linear and Cyclic Thr6-Bradykinin Analogues Containing N -Benzylglycine as a Replacement for Residues Phe 5 and Phe 8 ....Pages 628-629
Design, Synthesis and Conformational Analysis of Human Urotensin II (U-II) Analogues with Lactam Bridge....Pages 630-631
PACAP27 Analogues Incorporating Type II/II’ β-Turn Mimetics....Pages 632-633
Bicyclic β-Strand Templates: Epimerization and Biological Activity of Non-Electrophilic Serine Protease Inhibitors....Pages 634-635
Design, Synthesis and Biological Evaluation of Pilicides: Inhibitors of Pilus Assembly in Pathogenic Bacteria....Pages 636-637
Phenylahistin, a Small Dipeptidic Colchicine-Like Anti-Microtubule Agent: Total Synthesis and SAR Study of the Derivatives....Pages 638-639
New Antiproliferative Agents from a Peptidomimetic Library....Pages 640-641
Development of New Analogs of the Highly Potent Anti-Cancer Compound BKM-570....Pages 642-643
Design and Synthesis of a Selective PSA Cleavable Peptide-Doxorubicin Prodrug Which Targets PSA Positive Tumor Cells....Pages 644-646
Front Matter....Pages 473-473
Peptidic Inhibitors for Protein-Protein Interactions at Cell Surfaces....Pages 647-649
Prodrug Forms of Peptidomimetic HIV Protease Inhibitors Using Intramolecular Cyclization Reaction....Pages 650-651
Effect of Poly[L-Lysine] Based Polymer Polypeptides on Chemotaxis and Phagocytosis of the Unicellular Tetrahymena pyriformis GL....Pages 652-653
Costimulatory Blockade by CD28 Peptide Mimics: Suppression of Experimental Autoimmune Encephalomyelitis....Pages 654-655
Design and Synthesis of an Amide-Linked Angiotensin II Analogue with 3,5 Side Chain Bridge: Structural Resemblance of Ring Cluster Conformation with AT 1 Non-Peptide Antagonists....Pages 656-657
Sustained Delivery of an ApolipoproteinE Peptidomimetic Lowers Serum Cholesterol Levels in Dyslipidemic Mice....Pages 658-659
Design, Synthesis and Biological Evaluation of Novel Non-Peptide Opioid Ligands for Human Pain....Pages 660-661
Design and Synthesis of Novel Pure Motilin Antagonists....Pages 662-663
Active Somatostatin Analogues Containing Sugar Amino Acids....Pages 664-665
A Potent Non-Peptide Inhibitor of Anthrax Lethal Factor....Pages 666-667
Highly Potent Analogs of Human Parathyroid Hormone and Human Parathyroid Hormone-Related Protein....Pages 668-669
Glucagon-Like Peptide-1 Analogs with Significantly Improved in vivo Activity....Pages 670-671
Neuropeptide Y (NPY) Y1 Receptor Antagonists....Pages 672-673
Template-Directed Ligation of Peptides with Nucleobase Amino Acids....Pages 674-675
A General New Concept for the Development of Opioid Peptide Derived μ-, δ- and κ-Antagonists....Pages 676-678
Synthesis and Pharmacological Activity of Dmt-Tic Analogs with Highly Potent Agonist and Antagonist/Agonist Opioid Activity....Pages 679-680
A Novel Cyclic Opioid Peptide Antagonist Containing a Hydroxy Group in Place of the N-Terminal Amino Function....Pages 681-682
Modifications of the Tic Residue in TIPP-Peptides....Pages 683-684
Structure-Activity Relationships of Linear and Cyclic Nociceptin Analogs and Conformational Analysis by CD and NMR Spectroscopy....Pages 685-686
Design and Synthesis of Dynorphin A-(1–11) Analogs with C-Terminal Modifications and Evaluation of their Opioid Activity....Pages 687-688
Front Matter....Pages 473-473
C-Terminal Structure-Activity Relationships for the Novel Opioid Peptide JVA-901 (Venorphin)....Pages 689-690
Design and Synthesis of Bifunctional Peptides: Antagonists at CCKA/CCKB Receptors and Agonists at μ/δ Opioid Receptors....Pages 691-692
Role of the C-Terminal and Central Region of Gastrin for Recognition by the Human CCK 2 Receptor....Pages 693-694
Structure and Peptide Binding Specificity of the SH3 and SH2 Domain from a Self-Regulated Protein Tyrosine Kinase — BTK....Pages 695-696
Pseudoprolines for Studying Bioactive cis -Prolyl Conformations....Pages 697-698
Design of Oxytocin Antagonists Which Are More Selective than Atosiban in Rat Bioassays and in Human Receptor Assays....Pages 699-700
Highly Selective Cyclic Peptides for Human Melanocortin-4 Receptor (MC-4 R): Design, Synthesis, Bioactive Conformation, and Pharmacological Evaluation as an Anti-Obesity Agent....Pages 701-703
SAR of Melanin-concentration Hormone (MCH), an Important Regulatory Hormone in Feeding Behavior....Pages 704-705
Structure-Activity Relationship Studies (SAR) of Melanocortin Agonists Central His-Phe-Arg-Trp Sequence....Pages 706-707
The Development of a Novel Highly Selective and Potent Agonist for Human Melanocortin 4 Receptor....Pages 708-709
Synthesis and NMR Characterization of Melanin-Concentrating Hormone....Pages 710-711
Synergism Between Agouti Protein Fragment 91–131 and Melanin Concentrating Hormone....Pages 712-713
Development of a Human Growth Hormone Peptide Analogue AOD9604 into an Anti-Obesity Drug....Pages 714-715
Rational Approach to Stable, Universal Somatostatin Analogues with Superior Therapeutic Potential....Pages 716-718
 N -Methyl Scan of a sst1-Selective Somatostatin (SRIF) Analog....Pages 719-720
Exploring the “Double-Ring” Motif in Bradykinin Antagonists....Pages 721-722
Conformational Studies of Angiotensin II Cyclic Analogues....Pages 723-724
Identification of Key-Residues of Urotensin II, a Potent Mammalian Vasoconstrictor....Pages 725-726
Structure-Activity Studies on the Corticotropin Releasing Factor Antagonist Astressin, Minimal Sequence Necessary for Antagonistic Activity: Implications for a New Pharmacophoric Model....Pages 727-728
Solid-Phase Synthesis and Radiolabeling of a Bombesin Peptide Analog for Diagnostic Imaging of Tumors: A Preliminary Report....Pages 729-730
Front Matter....Pages 473-473
Investigation on the Structural Requirements for Binding Integrin α IIb β 3 ....Pages 731-732
Linear and Cyclic Peptides for Integrin α v β 6 Inhibition....Pages 733-734
The Synthesis of Collagen Peptides and Characterization of Their Inhibitory Effects on the Collagen Binding Activities of Integrins α 1 β 1 and α 2 β 1 ....Pages 735-736
Probing the Importance of the N-Terminal Helix of Parathyroid Hormone: Introduction of Cyclohexylalanine to Tether to the Membrane....Pages 737-738
Structure-Function Relationship Studies on Parathyroid Hormone (PTH) 1–34 Analogs Containing β-Amino Acid Residues in Positions 11, 12, and 13....Pages 739-741
Local Conformation Around Position 12 of the (1–34) Fragment of Parathyroid Hormone Probed by Substitution with Aib Residues....Pages 742-743
Positional Cyclization Scanning: A New Method to Evaluate the Bioactive Conformation of Glucagon....Pages 744-745
Age-Related Decreases of Calcitonin Gene-Related Peptide (CGRP)-Induced Hypotension in vivo and Vasorelaxant Responses in vitro in Rats....Pages 746-747
A Novel Series of Growth Hormone Secretagogues....Pages 748-749
Chimeric Mastoparans: Biological Probes and Designer Secretagogues....Pages 750-751
Design of Cyclic α-Defensin Dimers as Channel Forming BuildingBlocks....Pages 752-753
The Effect of Multiple Substitution of Aliphatic Amino Acids on the Structure, Function and Mode of Action of Lytic Peptides....Pages 754-755
Three-Dimensional Structure of Big Defensin, a Novel Antimicrobial Peptide Isolated from Horseshoe Crab....Pages 756-757
Selective Bioactivity of Synthetic Amphipathic Peptides Against Murine Macrophages Infected with Brucella abortus ....Pages 758-759
Antibacterial Peptides Derived from the C-Terminal Domain of the Hemolytic Lectin, CEL-III....Pages 760-761
Low Molecular Weight Ψ[CH 2 NH] Pseudopeptides Yield Potent Antimicrobial Agents....Pages 762-763
Synthesis and Study of the Antimicrobial Action of Cecropin A-Melittin Hybrids with Aib Substitution....Pages 764-765
Structure-Function Relationship of Gramicidin-Alamethicin Hybrid Analogs....Pages 766-767
Biaryl-Bridged Lipopeptides from Streptomyces sp. TÜ 6075....Pages 768-769
Generation of Bioactive Peptides Derived from Caseins Using a Lactobacillus helveticus Strain....Pages 770-771
Front Matter....Pages 473-473
Bioactive Peptides Produced by a Strain of Lactobacillus plantarum : Characterization and Partial Purification....Pages 772-773
Stilboflavins, a Natural Peptaibol Library from the Mold Stilbella flavipes ....Pages 774-775
Cyclic Analogues of the Insect Antimicrobial Peptides Drosocin and Apidaecin....Pages 776-777
Interaction of Antithrombin III-Binding Domain in Heparins with Novel Heparin Binding Peptides....Pages 778-779
Antithrombin III-Derived Novel Heparin Binding Peptides Have an Antagonistic Effect on Heparins....Pages 780-781
The Octapeptide (Fragment of Differentiation Factor HLDF) Exhibits Nuclease Activity and Induces Apoptosis....Pages 782-784
 In vivo Proteolytic Hemoglobin Products as Tissue Growth Promoters....Pages 785-786
Synthesis and Pharmacological Activity of Superagonists of the ORL1 Receptor....Pages 787-788
Rational Designing of CXCR-4 Agonists and Antagonists: Synthesis of Novel Cyclam Derivatives of Stromal Cell-Derived Factor (SDF-1)....Pages 789-790
A Computational Study of Conformational Properties for N -Methylated Azapeptide Models....Pages 791-792
Structural Requirements of Non-Mammalian Vasodilatory Peptide Maxadilan, an Excellent Agonist of PACAP Type 1 Receptors....Pages 793-794
Effect of Deficiency of Cytochrome C Oxidase Assembly Peptide Cox17p on Mitochondrial Functions and Respiratory-Chain in Mice....Pages 795-796
Circadian Rhythm Pacemaker Neuropeptide “PDF” in Nocturnal Insect Cricket Gryllus bimaculatus : cDNA Cloning, mRNA Expression, and Nuclear Localization....Pages 797-798
Design and Synthesis of the Hydroxamic Acid Variants Antitumorigenic and Antimetastatic Hydroxamate Based Ac-PHSXX′-NH 2 Sequences....Pages 799-800
Design, Synthesis and Evaluation of Growth Regulating SDF-1 Peptides on Breast Carcinoma Cells....Pages 801-802
Components of Tissue-Specific Peptide Pools as Negative Regulators of Cell Growth....Pages 803-804
HPLC Analysis, Modeling, and Biological Studies of Antiproliferative Heterocyclic Carboxamides....Pages 805-806
Macrophage Chemotactic Response to Elastin-Derived VGVAPG and VGVPG Permutations: A Structure-Activity Relationship and Receptor Binding Assay....Pages 807-808
Front Matter....Pages 809-809
Analysis and Evaluation of Rational Designed Calcium Binding Sites in CD2....Pages 811-813
Structural Basis for Selective Binding of Integrins to Extracellular Matrix....Pages 814-815
Front Matter....Pages 809-809
Regulation of the Promoter Binding Activity of a Bacterial Sigma Factor Explored Using Segmental Isotopic Labeling and NMR Spectroscopy....Pages 816-817
Chemically Engineering the Prion Protein Using Stepwise SPPS and Expressed Protein Ligation....Pages 818-819
Covalent and Non-Covalent Oligomerization of the Transmembrane α-Helix 4 from the Cystic Fibrosis Conductance Regulator....Pages 820-821
CtrΔe13, a Calcitonin Receptor Isoform Lacking 14 Amino Acids in Transmembrane Helix 7: Structure and Topology....Pages 822-823
Transmembrane Segment Peptides of the Ff Phage Major Coat Protein Form Parallel Homodimers....Pages 824-825
Refined 3D Model of hMC4R and Docking Study for hMC4R with α-Melanocyte Stimulating Hormone Analogue Ligands....Pages 826-827
Effect of Detergents on Intramolecular Helix-Helix Packing in a Membrane-Based Peptide Derived from CFTR....Pages 828-829
Primary Amphipathic Shuttle Peptides: Structural Requirements and Interactions with Model Membranes....Pages 830-831
Synthesis, Purification, and Analysis of the Transmembrane Domain of Phospholamban....Pages 832-833
Verification of a μ Opioid Receptor Model by Site-Directed Mutagenesis....Pages 834-835
Solid-Phase Synthesis and Chemical Ligation of Transmembrane Segments of Rhodopsin....Pages 836-837
Ion Gating and Selectivity in Gramicidin A....Pages 838-840
Docking of Transmembrane Helices Into Four Helix Bundles in the High Affinity IgE Receptor....Pages 841-842
Helical Net Plots and Surface Lipophilicity Mapping of Transmembrane Helices of Integral Membrane Proteins: Aids to 3D Structure Determination of Integral Membrane Proteins....Pages 843-844
Studies on the Involvement of a His Residue of mt1 GPCR TM Helix V in the Interaction with Melatonin....Pages 845-846
Biosynthesis and Biophysical Studies of Domains of sTE2P, a Yeast G Protein-Coupled Receptor....Pages 847-848
Transmembrane Segment Mimic Peptides Containing Peptoid Residues....Pages 849-850
Computational Chemistry and Opioidmimetics: Receptor-Ligand Interactions of Dmt-Tic Peptides....Pages 851-852
Conformational Model of Signal Transduction in the Transmembrane Region of the AT-1 Receptor....Pages 853-854
Role of the Water Medium in the Process of Signal Transmission from Peptides to Cellular Receptors....Pages 855-856
Front Matter....Pages 809-809
Structure-Based Design, Synthesis, and Surface Plasmon Resonance (SPR) Detection of Antagonists of the Grb2 SH2 Domain....Pages 857-858
Global Conformational Constraint in the Design of a Grb2 SH2 Domain Inhibitor....Pages 859-861
Local Conformational Constraint in the Design of a Grb2 SH2 Domain Inhibitor....Pages 862-863
Further Studies of the Signaling Mechanisms of the Antitumor Somatostatin Analogue TT-232....Pages 864-865
Generation of Cellulose Membrane-Bound Peptides with Free C-Termini: A Useful Approach for PDZ Binding Studies....Pages 866-867
A Focused Library Approach to PTP Inhibitor Discovery Predicated on the X-ray Structure of a PTPIB-Bound Lead Compound....Pages 868-869
Synthesis of the Ras-RBD Protein Pair....Pages 870-872
The Proline-Rich Antibacterial Peptide Family Inhibits Chaperone-Assisted Protein Folding....Pages 873-875
Probing the Binding Site of a Heptahelical Peptide Pheromone Receptor Using Photoaffinity Labelling, Site-Directed Mutagenesis and Spectroscopic Approaches....Pages 876-878
The Naturally Occurring Melanocortin Antagonist Agouti-Related Protein (AGRP) Possesses Similar and Distinct Interactions at the MC4 Receptor Compared with Melanocortin Agonist....Pages 879-880
Identification of Regions of the Epidermal Growth Factor Receptor Involved in Ligand Binding Specificity Using a High Affinity Form of the Ectodomain....Pages 881-883
Thrombin Receptor Aromatic Residues for Edge-to-Face CH/π Interaction with Ligand Phe-2-phenyl Group....Pages 884-885
Regions of G-Protein-Coupled Receptors Identified by Multiple Sequence Alignment....Pages 886-887
Tools for the Identification of Receptor Dimmers: Synthesis and Biological Evaluation of On-Resin Dimerized, Photosensitive Analogues of Angiotensin II....Pages 888-889
Minimization of Parathyroid Hormone Using Simultaneous Multiple Peptide Synthesis: Implications for Structure Based Drug Design....Pages 890-891
Structure-Activity Relationship Studies of New Cyclic MSH Analogues Using Cloned-Human Melanocortin Receptors Lead to Greater Selectivity and Inverse Agonists....Pages 892-893
Structure-Activity Relationships of Arodyn, a Novel Dynorphin A-(1–11) Analogue....Pages 894-895
Neurohypophyseal Receptors-Ligands: Where We Are After the Landmark Rhodopsin Structure Determination....Pages 896-897
Synthesis, Bioactivity and Receptor Binding of Fluorescent NBD Labeled Analogs of the Tridecapeptide Mating Pheromone of Saccharomyces cerevisiae ....Pages 898-899
Molecular Model of the BNP-NPR-A Receptor Complex....Pages 900-901
Front Matter....Pages 809-809
Characterizing the Interactions Between Cholecystokinin and the G-Protein Coupled Receptors CCK 1 and CCK 2 : An NMR-Based Study....Pages 902-904
Human Colon Cancers Recognize N -Carboxymethyl Gastrin by a Non-CCK 1 , Non-CCK 2 Receptor....Pages 905-906
Functional Characterization of Two Drosophila melanogaster Type A Allatostatin Receptors Expressed in CHO Cells....Pages 907-908
Receptor-Bound Conformation of α-Peptide of Transducin (G t ) is not Stabilized by a “π-Cation” Interaction but by Constrained Lactam Bridges Between Residues 341 and 350....Pages 909-910
Solution and Membrane-Bound Conformational Properties of a Peptide from the First Extracellular Loop of the Angiotensin II AT 1 Receptor....Pages 911-912
Synthesis of a Biotinylated Chemotactic Peptide Analog as a Probe for Formylpeptide-Receptor Interaction....Pages 913-914
Specific Activation of the Insulin Receptor by the Transmembrane Domain Peptides....Pages 915-916
Cyclopentapeptides as Rigidified Templates for Probing Interactions with the AT-1 Receptors....Pages 917-918
Receptor Binding Site of Arg-Lys Triple Repeat in Nociceptin Superagonist....Pages 919-920
Identification of Novel Ligands for Vasopressin V 2 Receptor from Positional Scanning Libraries....Pages 921-922
Diversity Generation and Guest-Templated Self-Sorting in Dynamic Combinatorial Libraries....Pages 923-924
NMR Studies of the Interaction of α-Bungarotoxin with a Mimotope of the Nicotinic Acetylcholine Receptor....Pages 925-926
Selection of Antagonists of Fibroblast Growth Factor from a Phage-Display Peptide Library....Pages 927-928
Front Matter....Pages 929-929
Peptide Carrier for Efficient Drug Transport Into Living Cells....Pages 931-932
Design of Novel Cell Penetrating Peptides....Pages 933-934
Synthesis and Targeting with Novel Multi-Mannosylated Glycopeptide Modules....Pages 935-936
Liposaccharides: Utilisation for Peptide Delivery and for Enhancing Synthetic Peptide Immunogenicity....Pages 937-939
Down-Regulation of HIV-1 Long Terminal Repeat Controlled Viral Transcription by DNA-Binding, Arginine-Rich Fusion Proteins Derived from HIV-1 TAT for the Direct Delivery into the Nucleus....Pages 940-941
New Insights Into the Membrane Translocating Process of the Tat Peptide Used for Cellular Delivery of Various Biological Molecules....Pages 942-943
DUROS® Osmotic Implant for the Delivery of Peptides and Proteins....Pages 944-945
Front Matter....Pages 929-929
Utilization of ICAM-1 Peptide Conjugates for Drug Targeting to T-Cells....Pages 946-947
Regulation of Cadherin-Cadherin Interaction: Secondary Structure of the HAV and ADT Peptides Derived from Human E-Cadherin Sequence....Pages 948-949
Translocation of Various Arginine-Rich Peptides and the Potential of These Peptides as Carriers for Intracellular Protein Delivery....Pages 950-952
Reversible PEGylation: Thiolytic Regeneration of Active Protein from Its Polymer Conjugates....Pages 953-954
Lipoamino Acid and Liposaccharide Conjugated Peptides: Enhancement of Bioavailability....Pages 955-956
Regulation and Multiplicity of Peptide Transporters in Model Systems....Pages 957-958
A Novel Class of Cell Permeable “Karyophilic” Peptides: NLS-Mediated Nuclear Import of Dermaseptin Derived Peptides in Intact Cells....Pages 959-960
Characterization of Translocation Behavior of Arginine-Rich Membrane-Permeable Peptides....Pages 961-962
Structure and Activity of the N-Terminal Peptides of HIV-1 Glycoprotein 41 Types M (Major) and O (Outlier)....Pages 963-964
Specific Cleavage at Lys-147/Gly-148 in the Serine Protease Domain of Human Factor IXaβ by Plasmin: Effect on Catalytic Efficiency and Factor Villa Binding....Pages 965-966
Stability and Peptide Binding Specificity of BTK SH2 Domain: Molecular Basis for X-Linked Agammaglobulinemia....Pages 967-968
Designing Peptide Drugs/Ligands for Pathological States. A New Paradigm for Design of Bioactive Peptide Hormones and Neurotransmitters....Pages 969-970
Alternate Aggregation Pathways of Alzheimer β-Amyloid Peptides....Pages 971-972
Diabetes mellitus (DM) Causes Severe Impairment of Hypotensive Responses in vivo and Vasorelaxant Responses in vitro to the Neuropeptide CGRP....Pages 973-974
Triple-Helical Peptide Analysis of Collagenolytic Protease Activity....Pages 975-977
Design of More Potent, Radioiodinatable and Fluorescent Vasopressin Hypotensive Peptide Agonists....Pages 978-979
Antagonism of the Neurochemical Effect of Thyrotropin-Releasing Hormone by Its Peptide Analog....Pages 980-981
Synthesis of Selective Substrates for Syk PTK....Pages 982-983
Synthesis of Potent and Enzymatically Stable 4– 18 F-Benzoyl-NT(8–13) Analogs for Tumour Diagnosis Using PET....Pages 984-985
 In vivo Imaging of Protease Activity and Drug Screening....Pages 986-987
Front Matter....Pages 929-929
Passive Repression of HIV-1 Long Terminal Repeat Enhancer Controlled Viral Transcription in HIV-1 Infected Cells by Cationic DNA-Binding Fusion Proteins....Pages 988-989
Passive Repression of HIV-1 Long Terminal Repeat Controlled Viral Transcription by Site-Directed Combinatorial Design of Artificial DNA-Binding Proteins Screened from Combinatorial Chemical Libraries....Pages 990-991
Fluorescent Biosensor for CrkII Phosphorylation by the Abl Tyrosine Kinase....Pages 992-993
Antibodies to Distinct Protein Epitopes from a Single Polyclonal Serum....Pages 994-995
Epitope Mapping of Anti-Type I Collagen Crosslinked N-Telopeptide Antibody with Synthetic Peptides....Pages 996-997
The Use of a Synthetic Biotinylated Peptide Probe for the Isolation of Adenomatous Polyposis Coli (APC) Tumor Suppressor Protein Complexes....Pages 998-999
Folding and Peptide Binding of TPR Motifs from SGT....Pages 1000-1001
CCT mRNA and CREB Phosphorylation Up Regulated by Peptide ZNC(C)PR in Rat Hippocampus....Pages 1002-1003
A Combination of HER-2 Peptide Epitope Vaccines Mediate Superior Biological Effects....Pages 1004-1005
Multivalent Vaccine Studies for HTLV-1 Associated Diseases....Pages 1006-1007
Evaluation of HTLV-1 Cytotoxic T-Cell Epitopes in HLA-A2.1 Transgenic Mice....Pages 1008-1009
New Branched Polypeptide Based Epitope-Conjugates: Synthesis and Immunrecognition....Pages 1010-1011
Evaluation of Synergistic Interaction Between Cytokines and Peptide Epitope Vaccines in Protection Against HER-2 Expressing Lung Metastases....Pages 1012-1013
Novel Classes of Neutrophil-Activating Peptides: Isolation and Their Physiological Significance....Pages 1014-1015
Affinity of the HIV-1-Neutralizing Monoclonal Antibody 2F5 for gp41 ELDKWA Peptide Analogues....Pages 1016-1017
A Discontinuous Antigenic Site Is Functionally Reproduced by Synthetic Peptide Constructions....Pages 1018-1020
Four-Segment Tandem Ligation of Proteins with Unusual Branched Architecture....Pages 1021-1022
Identification and Optimization of HIV-Specific CTL Antigens for Vaccine Design....Pages 1023-1024
The Natural T-Helper Cell Epitope Repertoire is Unlikely to Contain Glycopeptides with Extended Carbohydrate Side-Chains....Pages 1025-1026
Peptide Analogues of a Subdominant Epitope Expressed in EBV-Associated Tumors: Synthesis and Activity....Pages 1027-1028
Front Matter....Pages 929-929
Synthetic Epitopes from Equine Infectious Anemia Virus (EIAV) Surface and Core Proteins....Pages 1029-1030
B-Cell Linear Epitopes in the Conservative Regions of Hepatitis C Virus Envelope Glycoproteins....Pages 1031-1032
Synthesis of a Covalently Reactive Antigen Analog Derived from a Conserved Sequence of HIV-1 gp120....Pages 1033-1034
Isolation, cDNA Cloning, and Chemical Synthesis of Oryctes rhinoceros Defensin....Pages 1035-1036
Deamidation within a γ-Gliadin-Derived Peptide Enhances Its Recognition by Serum Antibodies of CD Patients....Pages 1037-1038
Identification of Conserved HIV-1-Derived Helper T Lymphocyte Epitopes Using Synthetic Peptides and High Throughput Binding Assays....Pages 1039-1040
Determining the Fate of Glycopeptides During Antigen Processing in Antigen Presenting Cells....Pages 1041-1042
Evaluation of Immune Response Elicited by Peptide Libraries Against Foot-and-Mouth Disease Virus....Pages 1043-1044
Peptoid-Peptide Hybrids: Design, Synthesis and MHC Binding....Pages 1045-1046
Synthetic Glycopeptide Models of MUC1 Core Protein....Pages 1047-1048
Cathepsin D Produces the Potent Antimicrobial Peptide Parasin I from Histone H2A in Scaleless Fish Skin....Pages 1049-1050
Characterization of Highly Stimulatory T Cell Ligands Identified Using Positional Scanning Libraries....Pages 1051-1052
Proteomics Approach for Identifying Interacting Partners of a C-Terminal Functional Peptide Derived from the Tumor Suppressor, p21 cip/waf1 ....Pages 1053-1054
Cuvette-Based Biosensors as Micropreparative Affinity Surfaces....Pages 1055-1056
A Comprehensive Database of Protein-Protein Interactions....Pages 1057-1059
Cell Attachment and Neurite Outgrowth Activities of Laminin Peptide-Conjugated Chitosan Membrane....Pages 1060-1062
Peptide-Amphiphile Induction of α-Helical Molecular Architecture and Interaction with Biomaterial Surfaces....Pages 1063-1064
TOAC Peptides as Catalysts of Enantioselective Oxidations....Pages 1065-1066
Synthesis of Arg-Gly-Asp-Ser Containing Oligopeptides and Evaluation of Their Cell-Attachment Activity....Pages 1067-1068
Back Matter....Pages 1069-1111