Pathophysiology and Pharmacotherapy of Cardiovascular Disease

Front Matter....Pages i-xxiii
Front Matter....Pages 1-1
Heart Failure, Introduction....Pages 3-20
Cardiac Prevention Guidelines....Pages 21-36
Pathophysiology of Heart Failure....Pages 37-55
Calcium Signaling in Cardiovascular Physiology and Pathology....Pages 57-81
Sympathetic Nervous System Signaling in Heart Failure and Cardiac Aging....Pages 83-105
The Parasympathetic Nervous System and Heart Failure: Pathophysiology and Potential Therapeutic Modalities for Heart Failure....Pages 107-128
Risk for Sudden Cardiac Death in Heart Failure: Underlying Mechanisms and Therapeutic Modalities....Pages 129-149
Pharmacological Management of Heart Failure and Device Therapy in Heart Failure....Pages 151-164
Exercise in Heart Failure: Effectiveness Versus Safety....Pages 165-177
Cardiac Muscle and the Troponins....Pages 179-192
Circulating Cardiac Troponins as Specific Biomarkers of Myocardial Damage: Clinical Considerations....Pages 193-209
Natriuretic Peptides and Biomarkers in the Diagnosis of Heart Failure....Pages 211-229
MicroRNAs in Cardiovascular Disease: From Pathogenesis to Treatment....Pages 231-252
MicroRNA Therapeutics in Cardiovascular Disease....Pages 253-263
Gene Therapy in Cardiovascular Disease....Pages 265-287
Front Matter....Pages 289-289
Cardiac Hypertrophy and Hypertrophic Cardiomyopathy: Introduction and Management....Pages 291-324
Myocardial Metabolic Abnormalities and Cardiac Dysfunction....Pages 325-341
Molecular Targets in the Treatment of Cardiac Hypertrophy....Pages 343-371
Front Matter....Pages 373-373
Acute Coronary Syndromes: Introduction and Pathophysiologic Classification....Pages 375-395
Pathophysiology and Management of Myocardial Infarction....Pages 397-424
Front Matter....Pages 373-373
Pathophysiology and Lifetime Risk Factors for Atherosclerosis and Coronary Artery Disease in Women and in the Elderly....Pages 425-441
Medical Management of Chronic Stable Angina....Pages 443-466
Therapy for Acute Coronary Syndrome and Unstable Angina....Pages 467-493
Drug-Eluting Stents and Coronary Artery Disease....Pages 495-524
Front Matter....Pages 525-525
Atherosclerosis, Introduction and Pathophysiology....Pages 527-546
Vascular Endothelial Dysfunction and Atherosclerosis: Role of Nitric Oxide System....Pages 547-561
Cardioprotective Role of Omega-3 Polyunsaturated Fatty Acids Through the Regulation of Lipid Metabolism....Pages 563-588
Prevention and Treatment of Atherosclerotic Vascular Disease: Hypolipidemic Agents....Pages 589-611
Prevention of Cardiovascular Disease: The Polypill Concept....Pages 613-632
Front Matter....Pages 633-633
Hypertension: Introduction, Types, Causes, and Complications....Pages 635-653
Pathophysiology of Hypertension....Pages 655-683
Blood Pressure Genomics....Pages 685-694
Hypertension and Vascular Endothelial Growth Factors....Pages 695-707
Role of Gi Proteins in Hypertension....Pages 709-721
Sympathetic and Renin–Angiotensin Activity in the Pathophysiology of Hypertension....Pages 723-749
Drugs Targeting RAAS in the Treatment of Hypertension and Other Cardiovascular Diseases....Pages 751-806
Calcium Channel Blockers in the Treatment of Hypertension....Pages 807-822
Diuretics for the Treatment of Hypertension....Pages 823-851
Centrally Acting Antihypertensive Agents in the Treatment of Hypertension....Pages 853-868
Vasodilators and Management of Hypertensive Emergencies....Pages 869-886
Front Matter....Pages 633-633
Combination Therapy for the Clinical Management of Hypertension....Pages 887-902
Resistant Hypertension: Definition, Prevalence, and Therapeutic Approaches....Pages 903-917
Drug Adherence in Hypertension....Pages 919-933
The Glycemic Consequences of Antihypertensive Medications....Pages 935-948
Pathophysiology and Treatment of Pulmonary Arterial Hypertension....Pages 949-974
Front Matter....Pages 975-975
Cardiac Arrhythmias: Introduction, Electrophysiology of the Heart, Action Potential and Membrane Currents....Pages 977-1002
Pathophysiology of Cardiac Arrhythmias: Arrhythmogenesis and Types of Arrhythmias....Pages 1003-1014
Proarrhythmic Effects of Antiarrhythmic and Non-antiarrhythmic Drugs....Pages 1015-1038
Drug-Induced Prolongation of the QT Interval: Present and Future Challenges for Drug Discovery....Pages 1039-1057
Treatment of Atrial Fibrillation and Atrial Flutter....Pages 1059-1079
Use of Mechanical Devices to Reduce Stroke in Atrial Fibrillation....Pages 1081-1099
Antiarrhythmic Drugs and Management of Ventricular Arrhythmias....Pages 1101-1133
Cardiac Arrest and Cardiopulmonary Resuscitation: Recent Advances in Management Approach for Cardiopulmonary Resuscitation....Pages 1135-1147
Front Matter....Pages 1149-1149
Valvular Heart Disease: Introduction, Clinical Pathogenesis, and Management....Pages 1151-1185
Mitral Regurgitation in Heart Failure: Mechanisms and Therapeutic Options....Pages 1187-1199
Pathophysiology and Management of Functional Tricuspid Regurgitation....Pages 1201-1220
Aortic Valve Stenosis and Aortic Regurgitation: Pathophysiology and Treatment....Pages 1221-1246
Induction of Valvular Heart Disease by Pharmacological Interventions....Pages 1247-1265
Front Matter....Pages 1267-1267
Pathophysiology and Pharmacotherapy of Adult Congenital Heart Disease....Pages 1269-1291
Cardiac Disease in Pregnancy....Pages 1293-1313
Front Matter....Pages 1267-1267
Placental Insufficiency: The Impact on Cardiovascular Health in the Mother and Her Offspring Across the Lifespan....Pages 1315-1329
miRNAs in Cardiovascular Development....Pages 1331-1342