Pathology of the Pancreas

Pathology of the Pancreas
Series Preface
Volume Preface
Acknowledgements
Editors Biography
Series Editor Biography
Contributors
A
	Acinar Cell Carcinoma
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Acinar Cell Nodules
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Acinar Cystic Transformation of the Pancreas
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Acinar-Ductal Metaplasia
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Acute Pancreatitis
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Agenesis
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Age-Related Changes
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Alcohol-Related Chronic Pancreatitis
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Anatomic Variants
		Introduction
		Embryological Basis
			Pancreas Divisum, Treatment
			Annular Pancreas, Treatment
			Heterotopic (Ectopic) Pancreatic Tissue, Treatment
			Pancreatobiliary Maljunction, Treatment
			Vascular Abnormalities
		Henle´s Trunk
		Cross-References
		References and Further Reading
	Anatomy of the Pancreas
		Anatomy
		Size, Weight
		Anatomical Considerations of the Common Surgical Procedures for Resection of Pancreatic Tumors
		References and Further Reading
	Annular Pancreas
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Autoimmune Pancreatitis
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
C
	Cystic Fibrosis
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Molecular Features
		Differential Diagnosis
		References and Further Reading
D
	Ductal Adenocarcinoma and Variants
		Synonyms
		Definition
		Clinical Features
			Incidence and Etiology
			Age
			Sex
			Site
			Treatment
		Outcome
		Macroscopy
		Microscopy
		Cytology
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		Histological Subtypes
			Adenosquamous and Squamous Cell Carcinoma
			Colloid Carcinoma
			Hepatoid Carcinoma
			Medullary Carcinoma
			Invasive Micropapillary Carcinoma
			Signet-Ring Cell (Poorly Cohesive Cell) Carcinoma
			Undifferentiated Carcinoma
		Undifferentiated Carcinoma with Osteoclast-Like Giant Cells
		Other Neoplasms
		Cross-References
		References and Further Reading
E
	Ectopic Tissue
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Embryogenesis and Organogenesis of the Pancreas
		Embryogenesis of the Pancreas
		Organogenesis of the Pancreas
		Lineage Differentiation
		References and Further Reading
F
	Familial and Inherited Pancreatic Cancer
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Foregut Cyst
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References
G
	Glucagon Cell Hyperplasia and Neoplasia
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Grossing of Distal Pancreatectomy Specimens, Surgical Pathology
		Synonyms
		Definition
		Principle
		Methodology
		Quality Aspects
		Applications
		Table with Examples (Links)
		References and Further Reading
	Grossing of Pancreatoduodenectomy Specimens, Surgical Pathology
		Synonyms
		Definition
		Principle
		Methodology
		Quality Aspects
		Applications
		Table with Examples (Links)
		References and Further Reading
H
	Haemochromatosis
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Hereditary Chronic Pancreatitis
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Histology of the Pancreas
		Anatomy and Macroscopy
		Function
		Size
		Microscopy
		References and Further Reading
I
	Intraductal Oncocytic Papillary Neoplasm of the Pancreas (IOPN) and IOPN with Associated Invasive Component
		Synonyms
		Definition
		Clinical Features
		Outcome
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Intraductal Papillary Mucinous Neoplasm (IPMN) and IPMN with Associated Invasive Component
		Synonyms
		Definition
		Clinical Features
		Symptoms and Signs
		Macroscopy
		Microscopy
			Gastric-type IPMN
			Intestinal-type IPMN
			Pancreatobiliary IPMN
			IPMN with Associated Invasive Component
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Intraductal Tubulopapillary Neoplasm (ITPN) and ITPN with Associated Invasive Component
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Islet Cell Changes
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References
L
	Laparoscopic and Robot-Assisted Pancreatic Resections
		Introduction
		Pancreatoduodenectomy
		Distal Pancreatectomy
		Enucleation
		Conclusion
		References and Further Reading
	Lobulocentric Atrophy
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		Cross-References
		References and Further Reading
			Clinical Features
	Lymphoepithelial Cyst
		Definition
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References
M
	Mixed Neuroendocrine-Non-neuroendocrine Neoplasms of the Pancreas (MiNENs)
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References
	Molecular Pathology of Acinar Cell Carcinoma
		Description
		Cross-References
		References and Further Reading
	Molecular Pathology of Acinar Cystic Transformation
		Synonyms
		Description
		References and Further Reading
	Molecular Pathology of Intraductal Papillary Mucinous Neoplasms
		Description
		Cross-References
		References and Further Reading
	Molecular Pathology of Mucinous Cystic Neoplasms
		Synonyms
		Description
		References and Further Reading
	Molecular Pathology of Neuroendocrine Carcinoma
		Synonyms
		Description
		Cross-References
		References and Further Reading
	Molecular Pathology of Neuroendocrine Tumors
		Synonyms
		Description
		References and Further Reading
	Molecular Pathology of Pancreatic Ductal Adenocarcinoma
		Synonyms
		Description
		Cross-References
		References and Further Reading
	Molecular Pathology of Pancreatic Intraepithelial Neoplasms
		Synonyms
		Description
		Cross-References
		References and Further Reading
	Molecular Pathology of Serous Cystic Neoplasms
		Synonyms
		Description
		References and Further Reading
	Molecular Pathology of Solid Pseudopapillary Neoplasms
		Synonyms
		Description
		References and Further Reading
	Molecular Subtypes of Pancreatic Ductal Adenocarcinoma
		Synonyms
		Description
		References and Further Reading
	Mucinous Cystic Neoplasm (MCN) and MCN with Associated Invasive Component
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References
	Multiple Endocrine Neoplasia 1 Syndrome
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Molecular Features
		Differential Diagnosis
		References and Further Reading
N
	Neuroendocrine Carcinoma of the Pancreas
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Neuroendocrine Neoplasm of the Pancreas (PanNEN)
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Neuroendocrine Tumors of the Pancreas, Well-Differentiated (PanNET Grade 1,2,3)
		Synonyms
		Definition
		Clinical Classification of PanNET
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Non-epithelial Neoplasms
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
P
	Pancreas Divisum
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Pancreatic Heterotopia
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Pancreatic Intraepithelial Neoplasia (PanIN)
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Pancreatitis, Rare Forms
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Pancreatobiliary Maljunction
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Pancreatoblastoma
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References
	Parasitic Cyst
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Pathology Reporting, Surgical Pathology
		Synonyms
		Definition
		Principle
		Methodology
		Quality Aspects
		Applications
		Table with Examples (Links)
		References and Further Reading
	Pseudocyst
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
R
	Retention Cyst
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References
S
	Secondary Neoplasms of the Pancreas
		Synonyms
		Definition
		Clinical Features
		Treatment
		Outcome
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Serous (Cystic) Neoplasms of the Pancreas
		Synonyms
		Definition
		Variants
		Macroscopy
		Microscopy
		Immunohistochemical and Molecular Phenotype
		Differential Diagnosis
		Treatment and Outcome
		References and Further Reading
	Serous Cystic Neoplasms of the Pancreas, VHL-Associated
		Synonyms
		Definition
		Macroscopy
		Microscopy
		Immunohistochemical and Molecular Phenotype
		Differential Diagnosis
		Treatment and Outcome
		References and Further Reading
	Serous Cystic Neoplasms, Macrocystic (Oligocystic) Type
		Synonyms
		Definition
		Macroscopy
		Microscopy
		Immunohistochemical and Molecular Phenotype
		Differential Diagnosis
		Treatment and Outcome
		References and Further Reading
	Simple Mucinous Cyst
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Solid Pseudopapillary Neoplasm (SPN)
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
T
	Tropical Pancreatitis
		Synonyms
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Immunophenotype
		Molecular Features
		Differential Diagnosis
		References and Further Reading
	Types of Pancreatic Resections
		Introduction
		Partial Pancreaticoduodenectomy with or Without Pylorus Preservation
		Distal Pancreatectomy
		Total Pancreatectomy With/Without Splenectomy
		Central Pancreatectomy
		Enucleation
		Duodenum-Preserving Pancreatic Resections
			Duodenum-Preserving Pancreatic Head Resection (Beger Procedure)
		Conclusion
		References and Further Reading
V
	Vascular Resections in Surgery for Pancreatic Cancer
		Introduction
		Venous Resections
		Arterial Resections
		Neoadjuvant Therapy and R0 Resection
		Resection Versus Palliative Chemotherapy and Palliative Surgery
		Conclusion
		References and Further Reading
	Von Hippel-Lindau Syndrome, Pathology of the Pancreas
		Definition
		Clinical Features
		Macroscopy
		Microscopy
		Molecular Features
		Differential Diagnosis
		References and Further Reading