Part B: Proteolytic Enzymes

Content: 
Series Editors
Page ii

Copyright Page
Page iv

Contributors to Volume 458
Pages xiii-xvii

Preface
Pages xix-xxi
David A. Hopwood

Volumes in Series
Pages xxiii-xlix

Chapter 1 Approaches to Discovering Novel Antibacterial and Antifungal Agents Review Article
Pages 3-28
Stefano Donadio, Paolo Monciardini, Margherita Sosio

Chapter 2 From Microbial Products to Novel Drugs that Target a Multitude of Disease Indications Review Article
Pages 29-58
Flavia Marinelli

Chapter 3 Discovering Natural Products from Myxobacteria with Emphasis on Rare Producer Strains in Combination with Improved Analytical Methods Review Article
Pages 59-91
Ronald O. Garcia, Daniel Krug, Rolf MГјller

Chapter 4 Analyzing the Regulation of Antibiotic Production in Streptomycetes Review Article
Pages 93-116
Mervyn Bibb, Andrew Hesketh

Chapter 5 Applying the Genetics of Secondary Metabolism in Model Actinomycetes to the Discovery of New Antibiotics Review Article
Pages 117-141
Gilles P. van Wezel, Nancy L. McKenzie, Justin R. Nodwell

Chapter 6 Regulation of Antibiotic Production by Bacterial Hormones Review Article
Pages 143-157
Nai‐Hua Hsiao, Marco Gottelt, Eriko Takano

Chapter 7 Cloning and Analysis of Natural Product Pathways Review Article
Pages 159-180
Bertolt Gust

Chapter 8 Methods for In Silico Prediction of Microbial Polyketide and Nonribosomal Peptide Biosynthetic Pathways from DNA Sequence Data Review Article
Pages 181-217
Brian O. Bachmann, Jacques Ravel

Chapter 9 Synthetic Probes for Polyketide and Nonribosomal Peptide Biosynthetic Enzymes Review Article
Pages 219-254
Jordan L. Meier, Michael D. Burkart

Chapter 10 Using Phosphopantetheinyl Transferases for Enzyme Posttranslational Activation, Site Specific Protein Labeling and Identification of Natural Product Biosynthetic Gene Clusters from Bacterial Genomes Review Article
Pages 255-275
Murat Sunbul, Keya Zhang, Jun Yin

Chapter 11 Sugar Biosynthesis and Modification Review Article
Pages 277-308
Felipe LombГі, Carlos Olano, JosГ© A. Salas, Carmen MГ©ndez

Chapter 12 The Power of Glycosyltransferases to Generate Bioactive Natural Compounds Review Article
Pages 309-333
Johannes Härle, Andreas Bechthold

Chapter 13 Nonribosomal Peptide Synthetases: Mechanistic and Structural Aspects of Essential Domains Review Article
Pages 337-351
M.A. Marahiel, L.‐O. Essen

Chapter 14 Biosynthesis of Nonribosomal Peptide Precursors Review Article
Pages 353-378
Barrie Wilkinson, Jason Micklefield

Chapter 15 Plasmid‐Borne Gene Cluster Assemblage and Heterologous Biosynthesis of Nonribosomal Peptides in Escherichia coli Review Article
Pages 379-399
Kenji Watanabe, Alex P. Praseuth, Mike B. Praseuth, Kinya Hotta

Chapter 16 Enzymology of β‐Lactam Compounds with Cephem Structure Produced by Actinomycete Review Article
Pages 401-429
Paloma Liras, Arnold L. Demain

Chapter 17 Siderophore Biosynthesis: A Substrate Specificity Assay for Nonribosomal Peptide Synthetase‐Independent Siderophore Synthetases Involving Trapping of Acyl‐Adenylate Intermediates with Hydroxylamine Review Article
Pages 431-457
Nadia Kadi, Gregory L. Challis

Chapter 18 Molecular Genetic Approaches to Analyze Glycopeptide Biosynthesis Review Article
Pages 459-486
Wolfgang Wohlleben, Evi Stegmann, Roderich D. SГјssmuth

Chapter 19 In Vitro Studies of Phenol Coupling Enzymes Involved in Vancomycin Biosynthesis Review Article
Pages 487-509
Dong Bo Li, Katharina Woithe, Nina Geib, Khaled Abou‐Hadeed, Katja Zerbe, John A. Robinson

Chapter 20 Biosynthesis and Genetic Engineering of Lipopeptides in Streptomyces roseosporus Review Article
Pages 511-531
Richard H. Baltz

Chapter 21 In Vitro Studies of Lantibiotic Biosynthesis Review Article
Pages 533-558
Bo Li, Lisa E. Cooper, Wilfred A. van der Donk

Chapter 22 Whole‐Cell Generation of Lantibiotic Variants Review Article
Pages 559-574
JesГєs CortГ©s, Antony N. Appleyard, Michael J. Dawson

Chapter 23 Cyanobactin Ribosomally Synthesized Peptides—A Case of Deep Metagenome Mining Review Article
Pages 575-596
Eric W. Schmidt, Mohamed S. Donia

Author Index
Pages 597-625

Subject Index
Pages 627-636