Oxygen Sensing: Molecule to Man

A Tribute to Robert W. Torrance....Pages 1-5
Reminiscence of Bob Torrance....Pages 7-8
Reminiscence of Bob Torrance....Pages 9-11
Plasticity and Multiplicity in the Mechanisms of Oxygen Sensing....Pages 13-23
Evolution of Human Hypoxia Tolerance Physiology....Pages 25-43
Comparative Aspects of High-Altitude Adaptation in Human Populations....Pages 45-62
Tibetan and Andean Contrasts in Adaptation to High-Altitutde Hypoxia....Pages 63-74
A Genomic Model for Differential Hypoxic Ventilatory Responses....Pages 75-85
Regulation of the Hypoxia-Inducible Factor-1α....Pages 87-99
Intracellular Pathways Linking Hypoxia to Activation of c-fos and AP-1....Pages 101-109
Hypoxia-Induced Regulation of mRNA Stability....Pages 111-121
Hypoxia, HIF-1, and the Pathophysiologi of Common Human Diseases....Pages 123-130
Gene Regulation during Hypoxia in Excitable Oxygen-Sensing Cells: Depolarization-Transcription Coupling....Pages 131-142
Regulation of Creb by Moderate Hypoxia in PC12 Cells....Pages 143-152
Reactive Oxygen Species as Regulators of Oxygen Dependent Gene Expression....Pages 153-159
A Glycolytic Pathway to Apoptosis of Hypoxic Cardiac Myocytes....Pages 161-175
Mitochondrial-Nuclear Crosstalk is Involved in Oxygen-Regulated Gene Expression in Yeast....Pages 177-184
Rox1 Medited Repression....Pages 185-195
Oxygen Dependence of Expression of Cytochrome C and Cytochrome C Oxdaso Genes in S. Cerevisiae ....Pages 197-208
Hypoxic and Redox Inhibition of the Human Cardiac L-type Ca 2+ Channel....Pages 209-218
Molecular Identification of O 2 Sensors and O 2 -Sensitive Potassium Channels in the Pulmonary Circulation....Pages 219-240
Chemosensing at the Carotid Body....Pages 241-248
Oxidant Signalling and Vascular Oxygen Sensing....Pages 249-257
Tissue PO 2 and Mitochondrial Enzymes....Pages 259-264
Regulation of Shaker -Type Potassium Channels by Hypoxia....Pages 265-274
HIF-1 is Essential for Multilineage Hematopoiesis in the Embryo....Pages 275-284
Dual Influence of Nitric Oxide on Gene Regulation During Hyoixua....Pages 285-292
Hypoxia Differentially Regulates the Mitogen- and Stress-Activated Protein Kinases....Pages 293-302
Chairman’s Summary: Mechanisms of Oxygen Homeostasis, Circa 1999....Pages 303-310
Oxygen, Homeostasis, and Metabolic Regulation....Pages 311-335
Evidence that Nitric Oxide Plays a Role in O 2 Sensing from Tissue NO and PO 2 Measurements in Cat Carotid Body....Pages 337-347
Carotid Body Gap Junctions: Secretion of Transmitters and Possible Electric Coupling Between Glomus Cells and Nerve Terminals....Pages 349-357
Short- and Long-Term Regulation of Rat Carotid Body Gap Junctions by cAMP. Identification of Connexin43, a Gap Junction Subunit....Pages 359-369
Subcellular Localization and Function of B-Type Cytochromes in Carotid Body and Other Paraganglionic Cells....Pages 371-375
Acetylcholine Sensitivity of Cat Petrosal Ganglion Neurons....Pages 377-387
Responses of Petrosal Ganglion Neurons in vitro to Hypoxic Stimuli and Putative Transmitters....Pages 389-396
The Metabolic Hypothesis Revisited....Pages 397-404
Effect of Adenosine on CO 2 Chemosensitivity....Pages 405-410
The Present Status of the Mechanical Hypothesis for Chemoreceptor Stimulation....Pages 411-418
Identification of an Oxygen-Sensitive Potassium Channel in Neonatal Rat Carotid Body Type I Cells....Pages 419-424
Significance of Ros in Oxygen Chemoreception in the Carotid Body Chemoreception....Pages 425-434
ATP-Dependent K + and Voltage-Gated Ca 2+ Channels in Endothelial Cells of Brain Capillaries....Pages 435-440
Different O 2 -Sensing Mechanisms by Different K + Channels....Pages 441-452
Response of Intracellulap pH to Acute Anoxia in Individual Neurons from Chemosensitive and Nonchemosensitive Regions of the Medulla....Pages 453-464
Hyperbaric Oxygen Depolarizes Solitary Complex Neurons In Tissue Slices Rat Medulla Oblongata....Pages 465-476
Chronic Hypoxia Induces Changes in the Central Nervous System Processing of Arterial Chemoreceptor Input....Pages 477-484
Acetylcholine is Released from in vitro Cat Carotid Bodies During Hypoxic Stimulation....Pages 485-494
Interactions Between Acetylcholine and Dopamine in Chemoreception....Pages 495-505
Interacton Between Catecholamines and Neuropeptides in the Carotid Body: Evidence for Dopamine Modulation of Neutral Endpepticdase Activity....Pages 507-515
Pharmacological Effects of Endothelin in Rat Carotid Body....Pages 517-525
Oxygen and Acid Chemoreception by Pheochromocytoma (PC12) Cells....Pages 527-537
Postnatal Changes in Cardiovascular Regulation During Hypoxia....Pages 539-548
Expression and Localization of A2a and Al-Adenosine Recretor Genes in the Rat Carotid Body and Petrosal Ganglia....Pages 549-558
Serotonin and the Hypoxic Ventilatory Response in Awake Goats....Pages 559-569
Peripheral Chemosensitivity in Mutant Mice Deficient in Nitric Oxide Synthase....Pages 571-579
Dipaminergic Excitation in Goat Carotid Body May be Metiated by Serotonin Receptors....Pages 581-587
Augmentation of Calcium Current by Hypoxia in Carotid Body Glomus Cells....Pages 589-599
O 2 -Chemosensitivity in Developing Rat Adrenal Chromaffin Cells....Pages 601-609
O 2 -Sensing by Model Airway Chemoreceptors....Pages 611-622
Morphological Adaptation of the Peptidergic Innervation to Chronic Hypoxia in the Rat Carotid Body....Pages 623-630
Continuous, but not Episodic Hypoxia, Induces Creb Phosphorylation in Rat Carotid Body Type I Cells....Pages 631-635
Intracellular PO 2 of the Carotid Body....Pages 637-644
Redox-Based Inhibition of K + Channel / Current is not Related to Hypoxic Chemosensory Responses in Rat Carotid Body....Pages 645-653
Effects of 2,4-Dinitrophenol (DNP) on the Relationship between the Chemosensory Activities of the Rat Carotid Body and the Intracellular Calcium of Glomus Cells....Pages 655-661
Estimation of CO 2 Chemosensitivity from the Carotid Body in Humans....Pages 663-670
Adenosine-Dopamine Interactions and Ventilation Mediated Through Carotid Body Chemoreceptors....Pages 671-684
Carotid Body NO-CO Interaction and Chronic Hypoxia....Pages 685-690
Interplay Between the Cytosolic Ca 2+ Increase and Potential Changes in Glomus Cells in Response to Chemical Stimuli....Pages 691-696
Characteristics of Carotid Body Chemosensitivity in the Mouse....Pages 697-704
Role of Substance P in Neutral Endopeptidase Modulation of Hypoxic Response of the Carotid Body....Pages 705-713
Effect of Barium on Rat Carotid Body Glomus Cell [Ca 2+ ] i and Carotid Chemosensory Response....Pages 715-722
A Dual Acid-Influx Transport System in the Carotid Body Type I Cell....Pages 723-732
L-Dopa and High Oxygen Influence Release of Catecholamines from the Cat Carotid Body....Pages 733-741
Effects of a Dopamine Agonist on Cytosolic Ca 2+ Changes Induced by Hypoxia in Rat Glomus Cells....Pages 743-748
Carotid Chemoreceptors Participation in Brain Glucose Regulation....Pages 749-760
Nitric Oxide Modulation of Carotid Chemoreception....Pages 761-768
O 2 and Respiration in Exercising Human Muscle....Pages 769-783
pH Sensitivity in the Isolated CNS of Newborn Mouse....Pages 785-788
Aortic Body Chemoreflex of the Anaesthetized Rat....Pages 789-792
Changes in the Peptidergic Innervation of the Rat Carotid Body a Month After the Termination of Chronic Hypoxia....Pages 793-799
Carotid Bodies and the Sigh Reflex in the Conscious and Anaesthetised Guinea-pig....Pages 801-813
Immunohistochemical Study of the Carotid Body During Hibernation....Pages 815-821
Neurochemical Reorganization of O 2 Chemoreflex Pathway after Carotid Body Denervation in Rats....Pages 823-828