Oxidative Stress and Aging

Front Matter....Pages I-XII
Oxidative stress, antioxidants, aging and disease....Pages 1-14
Longevity determinant genes, cellular dysdifferentiation and oxidative stress....Pages 15-19
Oxidative stress and apoptosis....Pages 21-26
Superoxide and hydrogen peroxide as cellularly generated life-signals in the balance between proliferation and cell death....Pages 27-33
Cellular aging and oxidative stress....Pages 35-43
Cellular nitrogen oxide production: Its role in endogeneous mutation and carcinogenesis....Pages 45-52
Vascular smooth muscle cell proliferation is controlled by d-α-tocopherol at the level of protein kinase C and of the transcription factor AP-1....Pages 53-62
DNA damage and epigenetic mechanisms of aging....Pages 63-67
Formation of 8-hydroxyguanine in DNA by aging and oxidative stress....Pages 69-76
Age-dependent DNA modifications (I-compounds): Effects of carcinogenesis and oxidative stress....Pages 77-87
Iron-induced carcinogenesis in experimental animals: A free radical mechanism of DNA damage and carcinogenesis....Pages 89-99
DNA repair, oxidative stress and aging....Pages 101-110
Poly(ADP-ribose) polymerase: Correlation of enzyme activity with the life span of mammalian species and use of a dominant negative version to elucidate biological functions of poly(ADP-ribosyl)ation....Pages 111-121
Antioxidant genes and other mechanisms involved in the extended longevity of Drosophila ....Pages 123-139
Novel approaches toward inhibition of the Maillard reaction in vivo : Search, isolation and characterization of prokaryotic enzymes which degrade glycated substrates....Pages 141-149
Age-associated changes of oxidative modification and turnover of proteins....Pages 151-158
Mitochondria, free radicals, neurodegeneration and aging....Pages 159-169
Free radicals and muscle damage due to immobilization of old animals: Effect of growth hormone....Pages 171-178
PCR analysis of mitochondrial DNA from normal and transgenic glutathione peroxidase mice....Pages 179-190
Free radicals in the pathogenesis of diabetes and its complications....Pages 191-201
Oxidative stress and its relationship to carcinogen activation....Pages 203-220
The chemoprevention of cancer by dietary carotenoids: Studies in mouse and human cells....Pages 221-235
Accumulation of ubiquitinated proteins in aging mouse brains....Pages 237-244
Protective action of Bio-normalizer against oxidative stress and brain disorders....Pages 245-257
Islet redox state, calcium uptake and insulin secretion: Effects of old age and oxidative stress....Pages 259-276
Free radical scavenger properties of EGB 761 on functional disorders induced by experimental diabetic retinopathy....Pages 277-286
Oxidative stress in neurobiology: An important role for iron....Pages 287-302
Parkinson’s disease, dopamine and free radicals....Pages 303-308
Oxidative stress and brain damage as the pathogenesis of epilepsy....Pages 309-317
Senile neurodegeneration: Pathogenic role of microglia-derived free radicals....Pages 319-330
Modulation of oxidative stress as a means of life-prolonging action of dietary restriction....Pages 331-342
Dietary vitamin E in oxidative stress and aging....Pages 343-354
Tea and its components as powerful antioxidants....Pages 355-365
Protective role of dietary antioxidants in oxidative stress....Pages 367-377
Nitrone spin-traps release nitric oxide reaction with reactive oxygen species: Possible mechanism of biological activity....Pages 379-386
Age-related changes in nitric oxide content and nitric oxide synthase activity in senescence-accelerated mouse (SAMP8) brain....Pages 387-391
Back Matter....Pages 393-399