Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies

Front Matter....Pages i-xxiii
Osteosarcoma at the end of the 20th century....Pages 1-5
Retroviruses and oncogenes associated with osteosarcomas....Pages 7-18
In vivo 31 P nuclear magnetic resonance spectroscopy of osteosarcoma....Pages 19-24
Perioperative blood transfusions and survival in osteosarcoma....Pages 25-28
Adjuvant interferon treatment in human osteosarcoma....Pages 29-32
Difference between osteosarcoma in southwest England and the Kanto area of Japan in relation to age, sex, and localization....Pages 33-38
Psychological effects of amputation in osteosarcoma....Pages 39-44
Late effects of therapy in survivors of childhood and adolescent osteosarcoma....Pages 45-48
An opinion supporting the role of high-dose methotrexate in the treatment of osteosarcoma....Pages 49-54
Doxorubicin: Role in the treatment of osteosarcoma....Pages 55-73
Pediatric osteosarcoma: Treatment of the primary tumor with intraarterial cis-diamminedichloroplatinum-II (CDP)— Advantages, disadvantages, and controversial issues....Pages 75-84
Intraarterial chemotherapy for osteosarcoma: Does the result really justify the effort?....Pages 85-92
Thermal chemosensitization of cDDP-resistant cells....Pages 93-100
Liposome-encapsulated muramyl tripeptide: A new biologic response modifier for the treatment of osteosarcoma....Pages 101-107
Pathological diagnosis of osteosarcoma: The validity of the subclassification and some new diagnostic approaches using immunohistochemistry....Pages 109-124
Histologic subclassification of osteosarcoma: Differential diagnostic problems and immunohistochemical aspects....Pages 125-137
Small cell osteosarcoma....Pages 139-149
Current status of DNA cytometry in osteosarcoma....Pages 151-161
Osteosarcomatosis and metastatic osteosarcoma....Pages 163-171
Experience of the EORTC Radiotherapy/Chemotherapy Group in osteosarcoma trials....Pages 173-175
Intraoperative radiation therapy for osteosarcoma....Pages 177-183
Surgery of Osteosarcoma of the extremities: Indications and complications in the recent Experience at the Istituto Ortopedico Rizzoli....Pages 185-203
Limb sparing for skeletally immature patients with osteosarcoma: The expandable prosthesis....Pages 205-211
A modular endoprosthetic system, noninvasively extendable, for young patients with osteosarcoma....Pages 213-220
A critique of techniques for reconstruction after internal hemipelvectomy for osteosarcoma....Pages 221-229
Diffusion of methotrexate from surgical acrylic cement....Pages 231-233
Hyperthermic isolated perfusion using cisplatin for treatment of the extremities....Pages 235-240
Hyperthermic isolation limb perfusion (HILP) in the management of extremity melanoma and sarcoma with particular reference to the dosage, pharmacokinetics, and toxicity of cisplatin....Pages 241-244
Effect of isolated limb perfusion with cisplatin (CDDP) on canine osteosarcoma....Pages 245-249
Salvage surgery for childhood osteosarcoma....Pages 251-260
The multi-institutional osteosarcoma study: An update....Pages 261-267
Treatment of osteosarcoma: Experience of the Cooperative Osteosarcoma Study Group (COSS)....Pages 269-277
The European Osteosarcoma Intergroup (E.O.I.) studies 1980–1991....Pages 279-286
The Childrens Cancer Group (CCG) Studies....Pages 287-291
An update of Scandinavian studies of osteosarcoma....Pages 293-298
Neoadjuvant chemotherapy for nonmetastatic osteosarcoma of the extremities: The recent experience at the Rizzoli Institute....Pages 299-308
Osteosarcoma of the extremities: Chemotherapy experience at Memorial Sloan-Kettering....Pages 309-322
Osteosarcoma studies at St. Jude Children’s Research Hospital from 1968 through 1990....Pages 323-326
A monocentric therapy study: An approach to optimize the results of the treatment of osteosarcoma by protocols based upon HDMTX, associated with systematic conservative surgery....Pages 327-332
The Mayo Clinic studies....Pages 333-338
Neoadjuvant chemotherapy for patients with osteosarcoma: University of Florida studies....Pages 339-346
Chemotherapy in osteogenic sarcoma: The experience of the Pediatric Department of the Gustave Roussy Institute....Pages 347-349
Results of therapy in osteosarcoma: Experience in Childrens hospitals in Buenos Aires....Pages 351-353
Osteosarcoma: Experience with the Rosen T10 protocol at RCH, Melbourne....Pages 355-359
Osteosarcoma of the limb: An institutional report of 10 years experience with neoadjuvant chemotherapy and delayed surgery....Pages 361-364
Osteosarcoma: Experience of the Tata Memorial Hospital, Bombay, India....Pages 365-369
Update of osteosarcoma in Ramathibodi, Thailand....Pages 371-374
Commentary on pathology....Pages 375-377
Is there a rational role for radiotherapy in the treatment of osteosarcoma?....Pages 379-381
Commentary on the use of presurgical chemotherapy....Pages 383-385
Critique on the use of presurgical chemotherapy: Recent trials as updated in this volume....Pages 387-389
Back Matter....Pages 391-407