Ocular Toxicology

Front Matter....Pages i-x
Welcome and Opening of the Congress....Pages 1-6
The ERG, EOG, and VEP in Rats....Pages 7-25
Retinal Toxicology Study Using Electrophysiological Methods in Rabbits....Pages 27-37
ERG Measurements in the Dog, Cat and Monkey for Toxicology Specially Type of Electrode and Anesthesia for ERG Recordings....Pages 39-51
Electroretinography in the Non-Human Primate as a Standardized Method in Toxicology....Pages 53-61
Effects of Clindamycin on Neural Function in the Isolated Perfused Vertebrate Retina....Pages 63-67
Determination of the Effect of Ketamine, Thiopental and Halothane on the Ocular Electroretinographic Examination of the Beagle Dog to Define Protocols to be Used in Dogs, Monkeys and Micropigs....Pages 69-77
Experimental Study of the Retinal Toxicity of Iron after Vitreous Hemorrhage....Pages 79-83
Retinal Tolerance of Intravitreal Low-Molecular-Weight Heparin, Colchicine or Interferon ß Determined by Eye-Cup ERG in Albino Rabbits....Pages 85-91
Normal ERG on Rhesus Monkeys (Macaca mulatta ): Preliminary Results of a Technic Using Subcutaneous Electrodes....Pages 93-97
Effects of Quinine on the Electroretinogram of the Beagle Dog....Pages 99-108
Effect of Different Vehicles on Ocular Kinetics/Distribution....Pages 109-120
Drug Distribution Studies in Single Lens Layers Through the Application of A Sectioning Technique....Pages 121-134
Ocular Pharmacokinetics of Some Proteolytic Drugs in the Course of Topical Application: Long Term Observation....Pages 135-144
New Method of Reverse Intraaterial Drug Infusion into Final Periorbital Channels of Ophthalmic Artery in Urgent Treatment of Toxic Opticneuropathy....Pages 145-152
Evaluation of the Effect of the Vehicle on Ocular Distribution and Bioavailability of Betaxolol....Pages 153-159
Continuous Flow Contact Lenses Delivery of Diclofenac to Rabbit Cornea and Aqueous Humor....Pages 161-165
One-Year Ocular Toxicity Study of Ofloxacin Ophthalmic Solution in Beagle Dogs....Pages 167-179
Topical Fluconazale: High Penetration without Corneal Toxicity....Pages 181-190
Relevance of Cataract Models in Rodents as a Tool to Evidence a Co- or Syncataractogenic Potential of Drugs in Preclinical Studies....Pages 191-195
Influence of Phakan R on the Toxicity of Naphthalene in Rat Lenses, Analyzed by Isoelectric Focusing of Single Lens Layers....Pages 197-203
Investigations into the Cataractogenic Potency of a Non-Tricyclic Antidepressant....Pages 205-210
Comparative Investigations on the Cataractogenic Effect of a Triazin-Derivative in Albino and Pigmented Rats: I. Effects Detected with a Slit Lamp....Pages 211-218
Regionality of Glycated Calf Lens Crystallin Subunits Demonstrated by Lectin Staining....Pages 219-225
Spatial Distribution of Adenosin Nucleotides in Lenses of Species with Different Accommodative Capacities....Pages 227-234
Hyperbaric Oxygen Therapy Induces a Lenticular Myopic Shift Even with Shorter Treatment Protocol: A Preliminary Report....Pages 235-240
Posterior Subcapsular Cataracts and Raised Intraocular Pressure are Caused by Prolonged Oral Corticosteroid Therapy in Adult Patients with Inflammatory Bowel Disease....Pages 241-248
 In Vitro Methods in Ocular Toxicology: Introductory Remarks....Pages 249-254
[ 3 H]-Arachidonic Acid Release as an Alternative to the Eye Irritation Test....Pages 255-261
Cytotoxic Effects of Antifungal Drugs on Cultured Human Conjunctival Cells....Pages 263-267
Characterization of Sialomucins Expressed by Human Conjunctival Goblet Cells....Pages 269-276
Critical Evaluation of the Evidence for an Association between Ocular Disease and Exposure to Organophosphorus Compounds....Pages 277-280
A Practical Testing Strategy for the Evaluation of the Oculotoxic Potential of Chemicals....Pages 281-285
Aesthesiometry-Azelastine Eye Drops Reduce Corneal Sensitivity in Rabbits, But Not in Dogs and Humans....Pages 287-295
Influence of Chronic Alcoholic Intoxication on Healing of Corneal Epithelial Defects. Effectivity of Treatment by Protease Inhibitor Contrycal (Aprotinin) and Autologous Fibronectin....Pages 297-301
The Use of Cyclosporine a in Veterinary Ophthalmology....Pages 303-315
Characterization of Human Tear Glycoproteins by Phast SDS Electrophoresis, Western Blotting and Lectin Binding....Pages 317-326
The Corneal Effects of 2-(2-Nitro-4-Trifluoromethyl-Benzoyl)-Cyclohexane 1,3-Dione (NTBC) in the Rat....Pages 327-334
Exacerbation of Spontaneous Rat Corneal Opacities in a Polymorphonuclear Elastase Inhibitor Toxicity Study....Pages 335-342
The Comet Assay: A Reliable and Sensitive Method for the Documentation of UV-B Induced DNA Damage....Pages 343-349
Spontaneous Ocular Findings and Esthesiometry / Tonometry Measurement in the Göttingen Minipig (Conventional and Microbiologically Defined)....Pages 351-362
Measurement of Intraocular Pressure in Cynomolgus Monkeys Using a Tonopen ® ....Pages 363-367
Lead-Intoxication of Dopaminergic Cells in the Retina....Pages 369-374
Back Matter....Pages 375-378