Obsessive-compulsive Disorder: Symptoms, Therapy and Clinical Challenges

Contents
Preface
Chapter 1
Obsessive-Compulsive Disorder:  A General Overview
	Abstract
	Abbreviations
	Introduction
	Epidemiology
	Symptoms and Clinical Manifestations
	Diagnosis and Classification
	Differential Diagnosis
	Comorbidity
		Psychiatric Comorbidity
		Neurological Comorbidity
		Immunological and Inflammatory Comorbidities
		Other Comorbidities
	Neuroanatomy
	Neurochemistry
		Neurogenetics
	Treatment
	Pharmacotherapy
		Selective Serotonin Reuptake Inhibitors (SSRIs)
		Clomipramine
		Serotonin–Norepinephrine Reuptake Inhibitors (SNRIs)
		Refractory OCD
		Glutamatergic Agents: The NMDA Receptor
	Other Medications
		Psychotherapy
			Deep TMS for Treatment-Resistant OCD
			Neurosurgery
			Stereotactic Ablation
			Deep Brain Stimulation
	Conclusion
	References
	Biographical Sketches
Chapter 2
Relevant Mechanisms in Treating Obsessive-Compulsive Disorder:  The Case for Domain-Specific Relevance with Scrupulosity  and Other Forms of Obsessions  and Compulsions
	Abstract
	Introduction
	A Highly Efficacious Treatment
		Challenges in the Treatment of OCD
	Reasons behind the Heterogeneity
		Mechanisms of Action
	Cognitive and Experiential Mechanisms: Religiosity as an Example
	The Role of Trauma and Other Psychological Constructs in the Etiology of OCD
	Implementation Within a Treatment Context
		Working with Religiosity
		Cultural Humility in Examining Cognitive Mechanisms  of Action
		Trauma and OCD
		Values as They Relate to Obsessive Content
		Emotional Change Processes
	Conclusion
	References
Chapter 3
Acute-Onset Subtypes of Pediatric Obsessive-Compulsive Disorder: Pediatric Acute-Onset Neuropsychiatric Syndrome  and Pediatric Autoimmune Neuropsychiatric Disorders Associated with  Streptococcal Infections
	Abstract
	Introduction
	Diagnostic Criteria
	Pathophysiology
	Clinical Aspects
	Treatment
		Antimicrobials and Secondary Prophylaxis
		Immunomodulatory Therapies
		Psychoactive Drugs and CBT
	Conclusion
	References
Chapter 4
The Effects of COVID-19 Pandemic  on Children and Adolescents with Obsessive-Compulsive Disorder
	Abstract
	Introduction
	Effects of COVID-19 Pandemic  on Children and Adolescents
	Effects of COVID-19 Pandemic  on Children and Adolescents with OCD
	Conclusion
	References
Chapter 5
A Review of Considerations in Assessing and Treating Religious-Themed Obsessions
	Abstract
	Introduction
	Understanding OCD and Scrupulosity
	A Review of Research:  Prevalence and Presentation
	Assessment and Intervention Implications
		Assessment
		Intervention
	Case Example
	Conclusion
	References
Index
Blank Page
Blank Page