Nuclear Magnetic Resonance Spectroscopy in Molecular Biology: Proceedings of the Eleventh Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israël, April 3–7, 1978

Front Matter....Pages i-ix
P-31 NMR of Nucleic Acids. Bond Angle and Torsional Effects....Pages 1-15
NMR Studies on Dynamic Properties of Nucleic Acid Base Pairs in Nonaqueous Solvents....Pages 17-30
NMR Studies and Minimum Energy Conformation Calculations on the 5′-Terminus of Mammalian mRNA....Pages 31-39
Solution Conformations of Purine(ß)Nucleosides and Analogs....Pages 41-51
Nitrogen-15 Nuclear Magnetic Resonance Spectroscopy of 15 N-Labeled Nucleotides....Pages 53-70
Co-Operative Conformational Properties of Nucleosides, Nucleotides and Nucleotidyl Units in Solution....Pages 71-85
The Quantitative Separation of Stacking and Self-Association Phenomena in a Dinucleoside Monophosphate by Means of NMR Concentration-Temperature Profiles: 6-N-(Dimethyl)Adenylyl- (3′,5′)-Uridine....Pages 87-101
The Contributions of the Purine Nitrogens to Stacking Association....Pages 103-110
Methylation Effects on Nucleic Acid Conformations....Pages 111-124
Structural Studies on the Yeast tRNA Phe by the 1 H NMR of Modified Bases. Effect of Removal of the Y Base and Anticodon Binding....Pages 125-136
Spectroscopic Studies of Drug-Nucleic Acid Interactions....Pages 137-146
A Model for the Specific Site Melting of DNA in Vivo ....Pages 147-160
On the Conformational Dependence of the Proton Chemical Shifts in Nucleosides and Nucleotides.IV. Proton Chemical Shifts in 3′-Nucleotides as a Function of Different Conformational Parameters....Pages 161-181
Some Comments and Comparisons Concerning the Use of “Ring-Current” Calculations in Elucidating Molecular Conformations....Pages 183-191
Carbon-13 NMR Results in the Field of Nitrogen Heterocycles the Detection of Protonation Sites....Pages 193-200
NMR Studies of the Molecular Dynamics of Peptides and Proteins....Pages 201-210
Structural Information from Photo-CIDNP in Proteins....Pages 211-229
Nitrogen 15 Nuclear Magnetic Resonance Investigations on Amino Acids....Pages 231-246
One-Bond C,H Coupling Constants, a New Parameter in Conformational Studies of Peptides? The Cyclo -Sarcosyls....Pages 247-260
NMR Saturation Transfer Studies of the Catalysis of the Reversible Hydration of Acetaldehyde by Carbonic Anhydrase....Pages 261-271
Conformation and Interaction with Small Molecules of Cyclic Hexa-Peptides as Studied by Nuclear Magnetic Resonance Spectroscopy and Circular Dichroism....Pages 273-283
 13 NMR Studies on Opioid Peptides; 13 C-Enriched Methionine-Enkephalin and α-Endorphin....Pages 285-296
NMR Studies of Selectively Deuteriated and Fluorine Labelled Dihydrofolate Reductase....Pages 297-310
Studies of 19 F Labeled Met-192 Chymotrypsin: An NMR Study of an Activating Moiety Near the Catalytic Serine....Pages 311-322
Principles in Substrate and Conformation Specificity of Nucleotide-Converting Enzymes....Pages 323-337
Cooperativity in the Binding of Ligands to Dihydrofolate Reductase....Pages 339-349
Studies of Gene-5 Protein Nucleic Acid Interaction....Pages 351-364
Structural Elucidation Studies of Aurintricarboxylic Acid, a Potent Inhibitor of Protein Nucleic Acid Interactions....Pages 365-379
Magic Angle Sample Spinning in Inhomogeneously Broadened Spin System—Application to Unsonicated Phospholipid Bilayers....Pages 381-391
Ionic Permeabilities of Membranes; NMR Kinetic Studies....Pages 393-403
Interaction of Cannabinoids with Model Membranes — NMR Studies....Pages 405-422
N.M.R. Spectra of Mucopolysaccharides....Pages 423-438
An in vivo 15 N NMR Study of Bacterial Cell Walls....Pages 439-459
The Application of Aromatic Ring Currents in the Elucidation of Drug-Ligand and Metallo-Porphyrin Complexations....Pages 461-479
Sodium Magnetic Resonance in Biological Systems. Interpretation of the Relaxation Curves.....Pages 481-491
NMR Spectroscopy of Tricyclic Non-Alternant Systems Containing Seven-Membered Rings, Dibenz [ b,f ] Oxepine and Dibenz [ b,f ] Azepine: Parents of Pharmacologically Active Systems....Pages 493-507
Back Matter....Pages 509-537