Nuclear Cardiology: Practical Applications

Contributors ix

Preface xiii

Section 1 Fundamentals of Nuclear Cardiology 1

1 Fundamentals of Nuclear Cardiology Physics C. David Cooke James R. Galt E. Lindsey Tauxe 3

2 Radiation Safety and Protection in Nuclear Cardiology James R. Galt C. David Cooke Jason S. Tavel 15

3 Radiopharmaceuticals for Cardiovascular Imaging James A. Case Gary V. Heller 29

4 Cardiac SPECT and PET Instrumentation James A. Case 49

5 Quality Control in SPECT, Dedicated PET, and Hybrid CT Imaging Sue Miller Sunil Selvin Joey Stevens 73

6 Radiation Exposure and Reduction Strategies in Myocardial Perfusion Imaging Michael C. Desiderio Gary V. Heller 97

7 Physician Certification and Laboratory Accreditation Robert C. Hendel Gursukhman Deep S. Sidhu 109

Section 2 Radionuclide Myocardial Perfusion Imaging 119

8 Exercise and Pharmacologic Stress Testing Seyed Mehdi Khalafi Archana Ramireddy Robert C. Hendel 121

9 SPECT Myocardial Perfusion Imaging Protocols Milena J. Henzlova Cole B. Hirschfeld Andrew J. Einstein 141

10 Cardiovascular Positron Emission Tomographic Imaging Matthew J. Memmott Parthiban Arumugam Gary V. Heller 155

11 Myocardial Blood Flow Quantitation in Clinical Practice Krishna K. Patel Gary V. Heller Timothy M. Bateman 175

12 Ventricular Function Prem Soman Saurabh Malhotra 195

13 Non-Cardiac Findings Rupa M. Sanghani Jamario Skeete 217

14 Interpretation and Reporting of SPECT and PET Myocardial Perfusion Imaging Robert C. Hendel Gary V. Heller 233

Section 3 Indications and Applications 271

15 Clinical Applications of Quantitation and Artificial Intelligence in Nuclear Cardiology Robert J.H. Miller Piotr J. Slomka 273

16 Appropriate Use of Nuclear Cardiology Techniques Gursukhman Deep S. Sidhu Robert C. Hendel 289

17 Evaluation of Patients with Suspected Coronary Artery Disease Sanjeev U. Nair Gary V. Heller 299

18 Evaluation of Patients with Known Coronary Artery Disease Javier Gomez Rami Doukky 323

19 Risk Stratification with Myocardial Perfusion Imaging Javier Gomez Rami Doukky 339

20 Nuclear Cardiovascular Imaging in Special Populations Robert C. Hendel Michael C. Desiderio Gary V. Heller 371

21 Preoperative Risk Assessment for Noncardiac Surgery Muhammad Siyab Panhwar Sumeet S. Mitter Robert C. Hendel 405

22 Radionuclide Imaging in Heart Failure Gautam V. Ramani Prem Soman 419

Section 4 Beyond Perfusion Imaging 429

23 Nuclear Cardiology Procedures in the Evaluation of Myocardial Viability Christiane Wiefels Fernanda Erthal Benjamin Chow Gary V. Heller Rob S.B. Beanlands 431

24 Radionuclide Imaging of Cardiac Innervation Mark I. Travin Ana Valdivia 457

25 Imaging Cardiac Amyloidosis Cory Henderson Dillenia Rosica Sharmila Dorbala 479

26 18F-FDC PET/CT for Imaging Cardiac Sarcoidosis and Inflammation Cesia Gallegos Bryan D. Young Edward J. Miller 495

27 Hybrid Imaging: SPECT-CT and PET-CT Cory Henderson Patrycja Galazka Sharmila Dorbala 517

Section 5 Review Questions 533

Answers and Explanations for Review Questions 563

Index 585