Nitric Oxide in Transplant Rejection and Anti-Tumor Defense

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
EPR Detection of Nitrosylated Compounds : Introduction with some Historical Background....Pages 3-35
Principles of Electron Paramagnetic Resonance Spectroscopy for Measurement of Free Radicals in Biological Tissues....Pages 37-48
EPR Detection and Biological Implications of Nitrosyl Nonheme Iron Complexes....Pages 49-82
Enzyme Independent Formation of Nitric Oxide in Tissues....Pages 83-93
Spin-Label No-Metry In Lipid Bilayer Membranes....Pages 95-107
EPR Imaging of Free Radicals in Biological Systems....Pages 109-118
Electron Paramagnetic Resonance Imaging of Nitric Oxide in Tissues....Pages 119-134
Front Matter....Pages 135-135
Allograft Rejection - Fact and Fancy....Pages 137-144
Immunobiology of Transplants: Specific and Nonspecific Mechanisms Involved in Allograft Rejection....Pages 145-156
Animal EPR Studies on Allo- and Xenograft Rejection....Pages 157-187
Nitric Oxide Effects on Murine Cardiac Allografts....Pages 189-203
Accelerated Rejection of Cardiac Allografts and Xenografts in Presensitized Rats and Gerbils....Pages 205-211
Involvement of Nitric Oxide in Amphibian Transplantation Immunity....Pages 213-226
Front Matter....Pages 227-227
Interactions Between Cytokine Induced Nitric Oxide and Intracellular Iron....Pages 229-238
Molecules Involved in the Recruitment and Regulation of Tumor-Associated Macrophages....Pages 239-252
The Role of Macrophage-Derived Nitric Oxide in Tumor Cell Death....Pages 253-265
Transcriptional Regulation of the Macrophage NOS2 Gene....Pages 267-276
Infection, Inflammation, and Cancer Mediated by Oxygen Radicals and Nitric Oxide....Pages 277-293
Induction of Iron-Nitric Oxide EPR Signals in Murine Cancers: Effects of Thiols and Cytokine-Induced Oxidant Stress....Pages 295-311
EPR Analysis of Tumor-Host Interactions....Pages 313-326
Front Matter....Pages 227-227
Ambivalent Role for Nitric Oxide in the Antitumor Immune Response....Pages 327-340
Identification of Nitric Oxide-Derived EPR Signals in Human Cancers....Pages 341-352
EPR Signals Detectable in Human Tumors....Pages 353-370
Back Matter....Pages 371-376