Nimodipine: Pharmacological and Clinical Results in Cerebral Ischemia

Front Matter....Pages I-XIV
Pharmacology Overview: Nimodipine in CNS Indications....Pages 1-8
Changes in Intracellular Free Calcium During Cerebral Ischemia and the Effects of Nimodipine on Calcium and Histological Damage....Pages 9-27
Experimental Models of Focal Ischemia: Results with Nimodipine....Pages 29-32
The Effect of Nimodipine Pretreatment on Focal Cerebral Ischemia in the Hypertensive Rat....Pages 33-44
Cardiac Arrest, Stroke, Subarachnoid Hemorrhage, and Severe Head Injury: What Do they Have in Common?....Pages 45-56
Dihydropyridines Attenuate Slow Excitatory Amino Acid Neurotoxicity....Pages 57-69
The Pathophysiology of Arterial Narrowing and Delayed Ischemic Deficit After Subarachnoid Hemorrhage....Pages 71-85
Advances in the Diagnosis and Treatment of Aneurysmal Subarachnoid Hemorrhage....Pages 87-94
Review of Trials on the Effect of Oral Nimodipine on Cerebral Infarction and Outcome Following Subarachnoid Haemorrhage....Pages 95-103
Treatment by Nimodipine of Ischemic Neurologic Deficits Due to Vasospasm....Pages 105-110
Safety Profile of Nimodipine in Patients with Subarachnoid Hemorrhage....Pages 111-123
Pathophysiology of Ischemic Brain Disease....Pages 125-131
Positron Emission Tomography in Nimodipine-Treated Patients with Acute Ischemic Stroke....Pages 133-143
Brain Regional Pharmacokinetics of 11 C-Nimodipine in Patients with Acute Stroke: A Preliminary Account of a Positron Emission Tomographic Study....Pages 145-150
Nimodipine and Other Calcium Antagonists in Acute Ischemic Stroke....Pages 151-164
Pool Analysis of the European Studies of Nimodipine in Acute Ischemic Stroke....Pages 165-180
Pharmacokinetics of Nimodipine in the Dog Resuscitated After Cardiopulmonary Arrest....Pages 181-189
Plasma Concentrations of Nimodipine in Patients Resuscitated After an Out-of-Hospital Cardiac Arrest....Pages 191-196
Influence of Nimodipine on Cerebral Blood Flow After Cardiac Arrest in Humans....Pages 197-204
Early Effects of Nimodipine on Intracranial and Cerebral Perfusion Pressures in Cerebral Anoxia After Out-of-Hospital Cardiac Arrest....Pages 205-214
Nimodipine in Out-of-Hospital Ventricular Fibrillation: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial....Pages 215-224
Epidemiology of Severe Head Injury: Socio-economic Consequences of Avoidable Mortality and Morbidity....Pages 225-234
Concussion Produces Dynamic Changes in Metabolism and Calcium Accumulation Resulting in Prolonged Neurological Deficits....Pages 235-240
The Effect of Nimodipine Following Experimental Head Injury in Rats....Pages 241-250
Spinal Cord Injury and the Possibilities of Treatment with Calcium Antagonists....Pages 251-261
The Effect of Nimodipine on Outcome After Head Injury: A Prospective Randomised Control Trial....Pages 263-277