Nicotine Psychopharmacology (Handbook of Experimental Pharmacology, Vol 192)

Front Matter....Pages i-xiv
Global Patterns of Nicotine and Tobacco Consumption....Pages 3-28
Nicotine Chemistry, Metabolism, Kinetics and Biomarkers....Pages 29-60
Nicotine Content and Delivery Across Tobacco Products....Pages 61-82
The Road to Discovery of Neuronal Nicotinic Cholinergic Receptor Subtypes....Pages 85-112
Magnetic Resonance Imaging Studies of Cigarette Smoking....Pages 113-143
In vivo Brain Imaging of Human Exposure to Nicotine and Tobacco....Pages 145-171
Molecular and Cellular Mechanisms of Action of Nicotine in the CNS....Pages 173-207
The Neuronal Pathways Mediating the Behavioral and Addictive Properties of Nicotine....Pages 209-233
Molecular Genetics of Nicotine Metabolism....Pages 235-259
Sex Differences in Nicotine Action....Pages 261-291
Recognising Nicotine: The Neurobiological Basis of Nicotine Discrimination....Pages 295-333
Effects of Nicotine in Experimental Animals and Humans: An Update on Addictive Properties....Pages 335-367
Discriminative Stimulus Effects of Nicotine in Humans....Pages 369-400
Rodent Models of Nicotine Withdrawal Syndrome....Pages 401-434
Approaches, Challenges, and Experience in Assessing Free Nicotine....Pages 437-456
Tobacco Industry Manipulation of Nicotine Dosing....Pages 457-485
Pharmacotherapy for Tobacco Dependence....Pages 487-510
Nicotine Psychopharmacology: Policy and Regulatory....Pages 511-534
Back Matter....Pages 535-544