New vaccine development establishing priorities. Volume II : Diseases of importance in developing countries

Title
 Copyright
 Acknowledgments
 Preface
 Abstract
 Contents
 1 Summary
 Selection of Candidates
 Determination of Health Benefits
 Disease Burden Estimates
 Infant Mortality Equivalence Values
 Total Disease Burden Values
 Vaccine Characteristics
 Predictions of Vaccine Development
 Definition of Probable Vaccine Target Population
 Estimation of Vaccine Utilization
 Estimation of Time to Licensure, Time to vaccine Adoption, and Delay of Vaccination Benefits: Discounting
 Estimation of vaccine Preventable Illness Calculation of Expected Health Benefits for Each VaccineCost Calculations
 Calculation of Morbidity Costs Averted by the Vaccine
 Vaccination Program Costs
 Integration of Costs
 Interpretation of Health Benefit and Net Cost Rankings
 Findings, Conclusions, Recommendations
 Recommendation
 Reference
 2 Priority Setting for Health Related Investments: A Review of Methods
 Methods for Project Ranking and Selection
 Multiattribute Accounting
 Multiattribute Scoring
 Decision Analysis With Multiple Objectives Cost-Effectiveness and Cost-Utility AnalysisBenefit-Cost Analysis
 Selection of an Approach
 Issues in Project Ranking Methodologies
 Sources of Estimates
 Sequential or “Lexicographic� Methods
 Interdependence Among Projects
 The “Portfolio� Question
 Summary
 References
 3 Overview of the Analytic Approach
 Method
 Interpretation of Results
 Guidelines
 Definition of Dominance
 Step 1
 Step 2
 Step 3
 Step 4
 Summary
 4 Comparison of Disease Burdens and Costs Elements of the System for Comparing Morbidity and Mortality Burdens Arising From various DiseasesTrade-Off Values
 Expression of Morbidity and Mortality Burdens
 Procedures Used in Deriving Disease Estimates
 Limitations of the Current Estimates
 Value Judgments in Quantifying Morbidity and Mortality
 IME Perspectives used in This Study
 The Effect of Adopting Other IME Perspectives
 Comparison of Direct Costs Resulting from Diseases
 Scope of Cost Calculations
 Procedures
 Findings
 Limitations of the Proposed System Summary and ConclusionsRecommendations
 References
 5 Predictions on Vaccine Development
 The Need for Predictions
 Selection of Candidates
 Vaccine Candidates and Target Populations
 Predictions on Vaccine Development
 Probability of Successful Development
 Cost of Development
 Time to Licensure
 Comments
 Predictions on Vaccine Characteristics
 Efficacy
 Adverse Reactions
 Production Technology, Delivery Requirements, and Cost/Dose
 Number of Doses and Route of Administration
 Conclusions