New Concepts in Viral Heart Disease: Virology, Immunology and Clinical Management

Front Matter....Pages I-XI
Front Matter....Pages 1-1
Etiology, Pathogenesis, and Pathophysiology of Dilated Cardiomyopathies....Pages 3-21
Virological, lmmunological and Clinical Features of Myocarditis and Dilated Cardiomyopathy....Pages 22-25
Epidemiology and Pathogenicity of Coxsackieviruses....Pages 26-32
Natural History of Acute Viral or Idiopathic Myocarditis: A Clinical and Endomyocardial Biopsy Follow-up....Pages 33-50
Myocarditis in Patients with Dilated Cardiomyopathy — Correlation with Clinical, Hemodynamic, and Biochemical Findings....Pages 51-60
Coxsackievirus Cardiomyopathy in Animal Models, Including the Augmenting Effect of Exercise During the Acute Phase....Pages 61-69
Front Matter....Pages 71-71
Replication, Molecular Biology, and Pathogenesis of Coxsackieviruses....Pages 73-78
A Murine Model for Coxsackievirus B3-Induced Acute Myocardial Necrosis for Study of Cellular Receptors as Determinants of Viral Tropism....Pages 79-92
Induction of Soluble Mediators During Coxsackievirus B3 Replication In Vitro and In Vivo....Pages 93-104
Persistence of Echovirus Type 6 in Cultured Cells....Pages 105-114
Detection and Typing of Enteroviruses by Nucleic Acid Probes and Monoclonal Antibodies....Pages 115-124
Generation of Enterovirus Group-Specific Antisera Using Bacterially Synthesized Coxsackievirus B3 Proteins....Pages 125-136
Front Matter....Pages 137-137
Myocarditis: A Postinfectious Autoimmune Disease....Pages 139-147
Viral Myocarditis: Immunogenetic and Autoimmune Aspects....Pages 148-159
Is Coxsackievirus B3-Induced Myocarditis in A/J Mice Mediated by an Autoimmune Response to Cardiac Myosin?....Pages 160-167
Virus-Induced Autoimmunity: Cross-Reactivity of Antiviral Antibodies with Self-Components....Pages 168-178
Immunopathogenic Mechanisms in Experimental Myocarditis: Evidence for Autoimmunity to the Virus Receptor and Antigenic Mimicry between the Virus and Cardiocyte....Pages 179-187
Coxsackie B3 Myocarditis: Genetic Aspects of Different Immunopathogenic Mechanisms in BALB/c and DBA/2 Mice. Antigenic Specificity of Heart-Reactive Antibodies in DBA/2 Mice....Pages 188-194
Interactions of Group B Coxsackieviruses with Immunocytes....Pages 195-204
Early Cellular Infiltrates in Coxsackievirus B3 Murine Myocarditis....Pages 205-214
Front Matter....Pages 215-215
Beta-Adrenoceptor Autoantibodies in Idiopathic Dilated Cardiomyopathy....Pages 217-224
Antibodies Against the Adenosine Di-/Triphosphate Carrier Cross-react with the Ca Channel — Functional and Biochemical Data....Pages 225-235
Antibodies and Autoantibodies Against ADP/ATP Carrier Enhance Calcium Current in Isolated Ventricular Myocytes....Pages 236-242
Antibodies Against Adenosine Di-/Triphosphate Carrier Alter Myocardial Function by Disturbing Cellular Energy Metabolism....Pages 243-258
Importance of Humoral and Cellular Immunological Parameters for the Pathogenesis of Viral Myocarditis....Pages 259-273
Characterization of T-Lymphocytes Cultured from Human Endomyocardial Biopsies....Pages 274-281
Front Matter....Pages 283-283
The Role of Biopsy in the Diagnosis and Follow-up of Myocarditis: A Critical Review....Pages 285-294
Impaired Myocardial Ultrastructure and Cytoskeleton in Cardiomyopathic Human Myocardium....Pages 295-302
Immunofluorescence Microscopy in the Diagnosis and Follow-up of Patients Suspected of Having Inflammatory Heart Disease....Pages 303-311
Induction of Major Histocompatibility Antigens on Myocardial Cells in Patients with Active Myocarditis and Idiopathic Cardiomyopathy....Pages 312-324
Evaluation of Immunohistological Data for the Diagnosis of Myocarditis....Pages 325-336
Enteroviral Heart Disease: Diagnosis by In Situ Hybridization....Pages 337-348
Persistence of Enterovirus RNA in Dilated Cardiomyopathy: A Progression from Myocarditis....Pages 349-362
Diagnosis of Acute Myocarditis with Radiolabeled Monoclonal Antimyosin Antibody: Immunoscintigraphic Evaluation....Pages 363-373
Front Matter....Pages 375-375
Animal Models for Therapeutic Trials of Viral Myocarditis: Effect of Ribavirin and Alpha Interferon on Coxsackievirus B3 and Encephalomyocarditis Virus Myocarditis....Pages 377-384
Antiviral Activity of Human Fibroblast Interferon in Coxsackievirus B3-Infected Cultured Human Heart Cells....Pages 385-392
Immunosuppressive Therapy in Myocarditis: Acute Viral Versus Chronic Idiopathic Myocarditis....Pages 393-401
Immunosuppressive Treatment in Myocarditis....Pages 402-425
The Role of Cardiac Transplantation in Patients with Active Myocarditis....Pages 426-432
Clinical and Experimental Aspects of Treatment for Viral Myocarditis....Pages 433-437
Front Matter....Pages 439-439
Alterations of Receptors and of Agonist Effectiveness in Myocardial Failure....Pages 441-448
Positive Inotropic Drugs in the Treatment of Chronic Congestive Heart Failure: A Critical Update....Pages 449-455
Effect of Angiotensin-Converting Enzyme Inhibitors on Myocardial Perfusion....Pages 456-464
Experimental Evidence for Cardioprotection Afforded by Ramipril, an Inhibitor of Angiotensin Converting Enzyme....Pages 465-474
Energetic Consequences of Pharmacological Therapy in Patients with Myocardial Failure....Pages 475-484
Effect of Angiotensin-Converting Enzyme Inhibitors on Energy Metabolism in Chronic Heart Failure - Enzymatic Studies of Myocardial Biopsies....Pages 485-493
Back Matter....Pages 495-504