Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, Second Edition

ویرایش:  
 
سری:  
ISBN (شابک) : 9781405196932, 9781444341256 
ناشر: Wiley-Blackwell 
سال نشر: 2011 
تعداد صفحات: 482 
زبان: English 
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) 
حجم فایل: 90 مگابایت 

قیمت کتاب (تومان) : 51,000

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology.  In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries.  Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, ?-synuclein and TDP-43) and in the extracellular compartments (e.g. ?-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts

Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis.

This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.Content:
Chapter 1 Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders (pages 1–5): Dennis W. Dickson
Chapter 2 Cell Death and Neurodegeneration (pages 6–9): Violetta N. Pivtoraiko and Kevin A. Roth
Chapter 3 Oxidative Stress and Balance in Neurodegenerative Diseases (pages 10–12): George Perry, Siddhartha Mondragon?Rodriguez, Akihiko Nunomura, Xiongwei Zhu, Paula I. Moreira and Mark A. Smith
Chapter 4 Protein Aggregation in Neurodegeneration (pages 13–17): Adriano Aguzzi and Veronika Kana
Chapter 5 Protein Degradation in Neurodegeneration: The Ubiquitin Pathway (pages 18–21): Lynn Bedford, Robert Layfield, Nooshin Rezvani, Simon Paine, James Lowe and R. John Mayer
Chapter 6 Genetics of Neurodegeneration (pages 22–25): John Hardy
Chapter 7 Transgenic Animal Models of Proteinopathies (pages 26–36): Naruhiko Sahara, Heather Melrose, Simon D'alton and Jada Lewis
Chapter 8 Clinical Aspects of Alzheimer's Disease (pages 37–50): David Knopman
Chapter 9 Genetics of Alzheimer's Disease (pages 51–61): Lars Bertram and Rudolph E. Tanzi
Chapter 10 Neuropathology of Alzheimer's Disease and its Variants (pages 62–91): Charles Duyckaerts and Dennis Dickson
Chapter 11 Amyloid?? Production (pages 92–96): Colin L. Masters and Konrad Beyreuther
Chapter 12 Elimination of Amyloid ? from the Brain, its Failure in Alzheimer's Disease and Implications for Therapy (pages 97–101): Roy O. Weller, Seth Love and James A. R. Nicoll
Chapter 13 Introduction to the Tauopathies (pages 103–109): Michel Goedert
Chapter 14 Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 (pages 110–134): Bernardino Ghetti, Zbigniew K. Wszolek, Bradley F. Boeve, Salvatore Spina and Michel Goedert
Chapter 15 Progressive Supranuclear Palsy and Corticobasal Degeneration (pages 135–155): Dennis W. Dickson, Jean?Jaques Hauw, Yves Agid and Irene Litvan
Chapter 16 Pick's Disease (pages 156–164): David G. Munoz, Huw R. Morris and Martin Rossor
Chapter 17 Argyrophilic Grain Disease (pages 165–170): Markus Tolnay and Heiko Braak
Chapter 18 Parkinsonism–Dementia Complex of Guam (pages 171–178): Kiyomitsu Oyanagi, Tomoyo Hashimoto and Mineo Yamazaki
Chapter 19 Postencephalitic Parkinsonism (pages 179–187): Kurt A. Jellinger
Chapter 20 Introduction to ??Synucleinopathies (pages 189–193): Maria Grazia Spillantini
Chapter 21 Parkinson's Disease (pages 194–223): Kurt A. Jellinger
Chapter 22 Dementia with Lewy Bodies and Parkinson's Disease Dementia (pages 224–237): Paul G. Ince
Chapter 23 Lewy Bodies in Conditions other than Disorders of ??Synuclein (pages 238–241): Coro Paisan?Ruiz, Laura Parkkinen and Tamas Revesz
Chapter 24 Multiple System Atrophy (pages 242–252): Janice L. Holton, Andrew J. Lees and Tamas Revesz
Chapter 25 Introduction to Trinucleotide Repeat Diseases (pages 253–257): H. Brent Clark
Chapter 26 Huntington's Disease (pages 258–272): John C. Hedreen and Raymund A. C. Roos
Chapter 27 Spinocerebellar Ataxias (pages 273–287): Hidehiro Mizusawa, H. Brent Clark and Arnulf H. Koeppen
Chapter 28 Friedreich's Ataxia (pages 288–298): Arnulf H. Koeppen
Chapter 29 Dentatorubral?Pallidoluysian Atrophy (pages 299–306): Hitoshi Takahashi, Mitsunori Yamada and Shoji Tsuji
Chapter 30 Spinal and Bulbar Muscular Atrophy (pages 307–312): Gen Sobue, Hiroaki Adachi and Masahisa Katsuno
Chapter 31 Introduction to Prion Disorders (pages 313–321): Adriano Aguzzi and Veronika Kana
Chapter 32 Sporadic Creutzfeldt–Jakob Disease (pages 322–335): Herbert Budka, Mark W. Head, James W. Ironside, Pierluigi Gambetti, Piero Parchi and Fabrizio Tagliavini
Chapter 33 Genetic Creutzfeldt–Jakob Disease (pages 336–345): Piero Parchi, Pierluigi Gambetti and Sabina Capellari
Chapter 34 Fatal Familial and Sporadic Insomnia (pages 346–349): Piero Parchi, Sabina Capellari and Pierluigi Gambetti
Chapter 35 A New Prion Disease: Protease?Sensitive Prionopathy (pages 350–353): Pierluigi Gambetti, Gianfranco Puoti, Qingzhong Kong and Wenquan Zou
Chapter 36 Variant Creutzfeldt–Jakob Disease (pages 354–363): James W. Ironside, Mark W. Head and Robert G. Will
Chapter 37 Gerstmann–Straussler–Scheinker Disease (pages 364–377): Bernardino Ghetti, Fabrizio Tagliavini, Gabor G. Kovacs and Pedro Piccardo
Chapter 38 Kuru (pages 378–380): Catriona Ann McLean
Chapter 39 Iatrogenic Creutzfeldt–Jakob Disease (pages 381–386): James W. Ironside, Richard S. G. Knight and Mark W. Head
Chapter 40 Introduction (pages 387–392): James Lowe
Chapter 41 Frontotemporal Lobar Degeneration with TDP?43 Pathology (pages 393–403): Ian R. A. Mackenzie and Manuela Neumann
Chapter 42 Neuronal Intermediate Filament Inclusion Disease (pages 404–411): Nigel J. Cairns
Chapter 43 Frontotemporal Lobar Degeneration with FUS Immunoreactive Inclusions (pages 412–417): Manuela Neumann and Ian R. A. Mackenzie
Chapter 44 Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis and Spinal Muscular Atrophy (pages 418–433): Michael J. Strong, Tibor Hortobagyi, Koichi Okamoto and Shinsuke Kato
Chapter 45 Introduction: Genetic Analysis as a Lumper and Splitter in Neurodegenerative Disease (pages 435–438): John E. Duda
Chapter 46 Inherited Amyloidoses and Neurodegeneration: Familial British Dementia and Familial Danish Dementia (pages 439–445): Tamas Revesz, Agueda Rostagno, Gordon Plant, Tammaryn Lashley, Blas Frangione, Jorge Ghiso and Janice L. Holton
Chapter 47 Neurodegeneration with Brain Iron Accumulation (pages 446–455): John E. Duda and Kurt A. Jellinger
Chapter 48 Familial Encephalopathy with Neuroserpin Inclusion Bodies (pages 456–460): Richard L. Davis and George H. Collins
Chapter 49 Hereditary Ferritinopathies (pages 461–466): Ruben Vidal, Marie Bernadette Delisle, Olivier Rascol and Bernardino Ghetti