Nature outlook: Nutrigenomics. How food shapes health and evolution

Cover
......Page 1
Contents
......Page 2
Big Science at the Table
......Page 3
Mother's Milk: A Rich Opportunity
......Page 6
The First Supper
......Page 9
Edible Advise
......Page 11
Of Beans and Genes
......Page 14
The Changing Notion of Food
......Page 17
More than Meets the Mouth
......Page 19
Tales of Adversity
......Page 21
A Flavour of the Future
......Page 22
Table 1 Hormonal and metabolic parameters and pancreas morphology......Page 24
References......Page 27
Methods References......Page 28
Figure 2 Female offspring demonstrate impaired glucose tolerance and insulin secretion to a glucose challenge.......Page 25
Table 2 Differentially expressed islet genes (P < 0.05) of female offspring in functionally enriched pathways......Page 26
Introduction......Page 29
Anthropometry and body composition......Page 30
Table 1 Anthropometric, biochemical and dietary parameters of the study participants stratified by the IGF rs680 genotype (data are presented as means±s.d.)......Page 31
Figure 1 Scatterplot of the observed values (open squares indicate GA+AA subjects; filled squares, GG subjects) and regression lines of predicted values (green line indicates GA+AA subjects; blue lines, GG subjects) of height values by IGF2 rs680 polymorp......Page 32
References......Page 33
Functional Genomics: Vitamin D and Disease
......Page 35
Introduction......Page 36
DNA isolation and clock genotyping......Page 37
Figure 1 Linkage disequilibrium (LD) plot across the CLOCK gene.......Page 38
Table 2 Characteristics of the population studied before and after behavioral treatment......Page 39
Table 4 Associations of CLOCK polymorphisms with changes in weight and metabolic parameters......Page 40
Figure 3 CLOCK variants and weight loss evolution during 28 weeks of treatment: (a) CLOCK rs3749474; (b) CLOCK rs4580704; (c) CLOCK rs180126 (3111TgtC).......Page 41
References......Page 42