Nanocellulose and Nanohydrogel Matrices: Biotechnological and Biomedical Applications

Content: List of Contributors xvii 1 Application of Nanocellulose for Controlled Drug Delivery 1Lalduhsanga Pachuau 1.1 Introduction 1 1.2 Biodegradability, Cytotoxicity, and Cellular Internalization of Nanocellulose 3 1.3 Nanocellulose in Nanoparticulate Drug Delivery 5 1.4 Nanocellulose in Microparticulate Drug Delivery 8 1.5 Nanocellulose in Tablet Formulations 10 1.6 Aerogel Systems 10 1.7 Hydrogels 11 1.8 Nanocellulose in Transdermal Drug Delivery 13 2 Bacterial Cellulose and Polyester Hydrogel Matrices in Biotechnology and Biomedicine: Current Status and Future Prospects 21Rajnikant Borkar, Sanghratna S. Waghmare, and Tanvir Arfin 2.1 Introduction 21 2.2 Chemical Structure of Cellulose 21 2.3 Types of Cellulose 21 2.4 Bacterial Cellulose 22 2.5 Chemical Structure of BC 22 2.6 History of BC 23 2.7 Biosynthesis of Bacterial Cellulose 23 2.8 Properties 23 2.9 Present Status of BC 28 2.10 Applications 29 2.11 Future Prospects 33 2.12 Polyester Hydrogels 33 2.13 Chemical Structure of Hydrogels 33 2.14 Types of Hydrogels 34 2.15 Properties of Hydrogels 34 2.16 Historical Background of Polyester Hydrogels 36 2.17 Recent Developments of Polyester Hydrogels 37 2.18 Applications of Polyester Hydrogels 38 3 Bacterial Nanocellulose Applications for Tissue Engineering 47Muhammed Lamin Sanyang, Naheed Saba, Mohammad Jawaid,Faruq Mohammad, and Mohd Sapuan Salit 3.1 Introduction 47 3.2 Cellulose 47 3.3 Nanocellulose and Its Types 50 3.4 Isolation and Preparation of Bacterial Cellulose 53 3.5 BC Properties for Tissue Engineering Applications 54 3.6 Tissue Engineering Applications 58 4 Cellulose-Based Nanohydrogels for Tissue Engineering Applications 67Kalyani Prusty and Sarat K. Swain 4.1 Introduction 67 4.2 Preparation of Hydrogels/Cellulosic Hydrogels 69 4.3 Characterization of Hydrogels/Cellulosic Hydrogels 71 4.4 Properties of Hydrogels 76 4.5 Cellulose-Based Nanohydrogels for Tissue Engineering Applications 81 5 Chitosan-Mediated Layer-by-Layer Assembling Approach for the Fabrication of Biomedical Probes and Advancement of Nanomedicine 91Faruq Mohammad and Hamad A. Al?]Lohedan 5.1 Introduction 91 5.2 Chitosan for Biofabrication 92 5.3 Derivatization of Chitosan 94 5.4 Chitosan-Mediated Biofabrication: Different Shapes and LBL Assembly 96 5.5 Chitosan-Mediated Assembly of Biomedical Probes and Devices 100 5.6 Factors Influencing the Characteristics of Chitosan toward Biomedical Applications 109 5.7 Summary and Conclusion 115 6 Hydrogels Based on Nanocellulose and Chitosane: Preparation, Characterization, and Properties 125Meriem Fardioui, Abou el kacem Qaiss, and Rachid Bouhfid 6.1 Introduction 125 6.2 Polymeric Aerogels 126 6.3 Chitosan and Functionalized Chitosan Hydrogels 131 6.4 Biopolymeric Aerogels in Biomedical Applications 134 7 Cellulose Nanocrystals and PEO/PET Hydrogel Material in Biotechnology and Biomedicine: Current Status and Future Prospects 139Shoeb Athar, Rani Bushra, and Tanvir Arfin 7.1 Introduction 139 7.2 Cellulose Nanocrystals 140 7.3 Polyethylene Oxide (PEO)/Polyethylene Terephthalate (PET) Hydrogel 155 8 Conducting Polymer Hydrogels: Synthesis, Properties, and Applications for Biosensors 175Yu Zhao 8.1 Introduction 175 8.2 Synthesis and Processing of CPHs 177 8.3 CPHs for Electrochemical Biosensors 182 8.4 Conclusion 200 9 Nanocellulose and Nanogels as Modern Drug Delivery Systems 209Misu Moscovici, Cristina Hlevca, Angela Casarica, and Ramona?]Daniela Pavaloiu 9.1 Introduction 209 9.2 Nanoparticles as Drug Delivery Systems 210 9.3 Nanocelluloses 212 9.4 Nanogels 223 10 Recent Advances on Inhibitors of Apoptosis Proteins (IAP) Particularly with Reference to Patents 271Riyaz Syed, Prema L. Mallipeddi, Syed Mohammed Ali Hussaini, Rahul V. Patel, A. Prasanth Saraswati, and Ahmed Kamal 10.1 Introduction 271 10.2 Patent Assessments 275 10.3 Other Heterocyclics as IAPs 279 11 Nanohydrogels: History, Development, and Applications in Drug Delivery 297Muhammad Akram and Rafaqat Hussain 11.1 Introduction 297 11.2 History 297 11.3 Classification of Hydrogels Based on the Type of Cross-Link Junctions 301 11.4 Classification of Hydrogels Based on Properties 305 11.5 Classification of Interpenetrating Network Hydrogels 307 11.6 Classification Based on Source 309 11.7 Properties of Hydrogels 309 11.8 Nanohydrogels and Their Applications 313 12 Nanofibrillated Cellulose and Copoly(amino acid) Hydrogel Matrices in Biotechnology and Biomedicine 331Azhar U. Khan, Nazia Malik, and Tanvir Arfin 12.1 History and Background of Celluloses 331 12.2 Structure of Cellulose 331 12.3 Nanocelluloses 333 12.4 Hydrogels 340 Index 353