Motor Neuron Disorders

Content: 
Edited By
Page iii

Copyright
Page iv

Contributing Authors
Pages vii-x

Series Preface
Page xi
Arthur K. Asbury, Anthony H.V. Schapira

Preface
Pages xiii-xv

Acknowledgments
Page xvii

Chapter 1 Clinical Principles in the Diagnosis of Motor Neuron Disorders Original Research Article
Pages 3-15
Michael Swash

Chapter 2 Pathology of Motor Neuron Disorders Original Research Article
Pages 17-49
Stephen Wharton, Paul G. Ince

Chapter 3 Neurophysiological Investigation of Motor Neuron Disorders Original Research Article
Pages 51-72
Kerry R. Mills

Chapter 4 Neuroimaging in Motor Neuron Disorders Original Research Article
Pages 73-108,cp1
Erik P. Pioro

Chapter 5 Clinical Aspects of Sporadic Amyotrophic Lateral Sclerosis/Motor Neuron Disease Original Research Article
Pages 111-143
Lewis R. Rowland

Chapter 6 Cognitive Impairment in the Motor Neuron Disorders Original Research Article
Pages 145-166,cp1
Michael J. Strong, Catherine Lomen-Hoerth, Wenchang Yang

Chapter 7 Epidemiology of Amyotrophic Lateral Sclerosis/Motor Neuron Disease Original Research Article
Pages 167-205
Carmel Armon

Chapter 8 Genetic Aspects of Amyotrophic Lateral Sclerosis/Motor Neuron Disease Original Research Article
Pages 207-235
Peter M. Andersen

Chapter 9 Cellular Biological Effects of Copper/Zinc Superoxide Dismutase Mutations Original Research Article
Pages 237-257
Andrew J. Grierson, Pamela J. Shaw

Chapter 10 Excitotoxicity and Oxidative Stress in Pathogenesis of Amyotrophic Lateral Sclerosis/Motor Neuron Disease Original Research Article
Pages 259-284,cp1
Philip Van Damme, Ludo Van Den Bosch, Wim Robberecht

Chapter 11 Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis Original Research Article
Pages 285-313
Clare Wood-Allum, Pamela J. Shaw

Chapter 12 Cytoskeletal Abnormalities in Amyotrophic Lateral Sclerosis/Motor Neuron Disease Original Research Article
Pages 315-339
Janice Robertson, Jean-Pierre Julien

Chapter 13 Role of Microglia in Amyotrophic Lateral Sclerosis Original Research Article
Pages 341-355,cp1
Michael J. Strong, Weiyan Wen

Chapter 14 Cell Death Pathways in Amyotrophic Lateral Sclerosis Original Research Article
Pages 357-377
Serge Przedborski, Peter G.H. Clarke

Chapter 15 Factors Underlying the Selective Vulnerability of Motor Neurons to Neurodegeneration Original Research Article
Pages 379-398,cp1-cp2
Heather D. Durham

Chapter 16 Spinal Muscular Atrophy Original Research Article
Pages 401-424,cp1-cp2
Kevin Talbot, Kay E. Davies

Chapter 17 Kennedy's Disease Original Research Article
Pages 425-434,cp1-cp2
Charlotte J. Sumner, Kenneth H. Fischbeck

Chapter 18 Hereditary Spastic Paraparesis Original Research Article
Pages 435-462
Christopher J. McDermott, Pamela J. Shaw

Chapter 19 Quality of Life and Psychosocial Aspects of Care of Patients with Amyotrophic Lateral Sclerosis Original Research Article
Pages 465-484
Deborah F. Gelinas, Robert G. Miller

Chapter 20 Symptom Control in Amyotrophic Lateral Sclerosis/Motor Neuron Disease Original Research Article
Pages 485-496
Johanna Anneser, Gian Domenico Borasio

Chapter 21 Disease-Modifying Therapies in Motor Neuron Disorders: The Present Position and Potential Future Developments Original Research Article
Pages 497-544
Martin R. Turner, P. Nigel Leigh

Index
Pages 545-569