Mononitrate II

Front Matter....Pages I-XIII
Introduction....Pages 1-2
Front Matter....Pages 3-3
Pharmacodynamics of Organic Nitrates — In Vitro and In Vivo Studies....Pages 5-12
Differential Effects of Isosorbide-5-Mononitrate on Epicardial Coronary Arteries and Relevant Hemodynamic Parameters: Special Aspects of Nitrate Action....Pages 13-19
Effect of Isosorbide-5-Mononitrate on CoronaryCollateral Blood Flow in Dogs....Pages 20-27
Overview of the Pharmacokinetics of Isosorbide-5-Mononitrate....Pages 28-36
Slow Release Isosorbide-5-mononitrate: Advantage or Disadvantage?....Pages 37-46
Pharmacokinetics of Organic Nitrates and Their Metabolites: Are They Relevant in Therapy?....Pages 47-52
Front Matter....Pages 53-53
Is a Twice Daily Dosage of Isosorbide-5-Mononitrate Sufficient in the Treatment of Stable Angina Pectoris?....Pages 55-60
Acute Dose Response of Isosorbide-5-Mononitrate in Patients with Effort Angina....Pages 61-68
A Comparison of Isosorbide-5-Mononitrate and Transdermal Glyceryl Trinitrate: Acute Effects and Tolerance Development During Chronic Therapy....Pages 69-81
Factors Influencing Tolerance in Nitrate Therapy: A Review....Pages 82-98
Front Matter....Pages 99-99
Nifedipine and Nitroglycerin: A Comparison of Acute Effects on Hemodynamic Determinants of Myocardial Oxygen Consumption and Supply During Exertional Angina....Pages 101-108
Concentration-Dependent Relaxation of Isolated Human Venous Vessel Strips by Isosorbide Dinitrate and Isosorbide-5-Mononitrate....Pages 109-119
Isosorbide-5-Mononitrate in Portal Hypertension and Cirrhosis: A Study of the Effect and Mechanism of Action....Pages 120-123
Effects of Isosorbide-5-Mononitrate on Atrial-Pacing-Induced Left-Ventricular Wall Motion Abnormalities....Pages 124-128
Effects of Isosorbide-5-Mononitrate on Hemodynamic Parameters and Left-Ventricular Function in Patients with Coronary Heart Disease....Pages 129-132
Hemodynamic Effects of Isosorbide-5-Mononitrate in Patients with Heart Failure Following Acute Myocardial Infarction....Pages 133-137
The Treatment of Congestive Cardiomyopathy with Vasodilator Drugs: Comparative Effects of Three Different Agents....Pages 138-150
Front Matter....Pages 151-151
Acute Study with Isosorbide-5-Mononitrate in Vasospastic Angina....Pages 153-158
Preventative Effects of Isosorbide-5-Mononitrate on Myocardial Ischemia Induced by Hand-Grip Test: An Echocardiographic Study....Pages 159-164
Front Matter....Pages 165-165
Differential Effects of Nitrates and Calcium Antagonists on the Coronary Vasculature in Conscious Patients....Pages 167-177
Cardiovascular Function and Exercise Tolerance of Patients with Myocardial Infarction and Standardized Physical Training after Isosorbide-5-Mononitrate and Nifedipine....Pages 178-183
An Interim Report on the Efficacy of Isosorbide-5-Mononitrate in a Sustained Release Formulation in Patients with Stable Angina....Pages 184-186
Exercise Response of Patients with Coronary Artery Disease during Treatment with Isosorbide-5-Mononitrate and slow release Nifedipine....Pages 187-195
Haemodynamic and Anti-Ischaemic Effects of Isosorbide 5-Mononitrate and Verapamil....Pages 196-204
Efficacy of Isosorbide-5-Mononitrate and Diltiazem in Patients with Myocardial Ischemia....Pages 205-212
Use of Nitrates Today....Pages 213-231
Front Matter....Pages 233-233
Comparative Dose-response of Isosorbide-5-Mononitrate and Isosorbide Dinitrate....Pages 235-237
Comparison of the Efficacy and Acceptability of Isosorbide 5-Mononitrate, Isosorbide Dinitrate and Propranolol in the Management of Angina Pectoris....Pages 238-241
Medium-Term Assessment of Isosorbide-5-Mononitrate in Effort Angina: Dependence of Efficacy on Basic Hemodynamic Conditions....Pages 242-247
The Effect of Isosorbide-5-Mononitrate and Metipranolol, Alone and in Combination, on Ventricular Function....Pages 248-252
Efficacy and Tolerance of Isosorbide-5-Mononitrate with Atenolol in Chronic Stable Angina....Pages 253-257
Front Matter....Pages 259-259
Physiological Aspects of Pain Perception and Transmission....Pages 261-266
Painful Stimuli from the Heart....Pages 267-269
Variability in the Perception of Painful Stimuli in Patients with Silent Myocardial Ischemia....Pages 270-284
Painless Ischemia: Incidence, Characteristics, Significance, and an Algorithm for Management....Pages 285-292
Precis of the Panel Discussion....Pages 293-299
Back Matter....Pages 301-302