Molecularly Imprinted Polymers as Advanced Drug Delivery Systems: Synthesis, Character and Application

Preface
Contents
Chapter 1: Introduction
	1.1 A Brief History of Imprinting
	1.2 General Principle of Molecular Imprinting
	1.3 The Imprinting Matrix
		1.3.1 Organic Matrix
		1.3.2 Inorganic Matrix
			1.3.2.1 Silica Gel Matrices
			1.3.2.2 TiO2 Matrices
			1.3.2.3 Imprinting in Zeolites
		1.3.3 Magnetic Matrix
	1.4 Key Issues for a Rational Design
		1.4.1 Template
		1.4.2 Functional Monomer
		1.4.3 Cross-Linker
		1.4.4 Solvent
		1.4.5 Temperature
	References
Chapter 2: Synthetic Strategies for the Generation of Molecularly Imprinted Polymers
	2.1 Introduce
	2.2 Covalent Imprinting
		2.2.1 Covalent Imprinting with Boronate Esters
		2.2.2 Covalent Imprinting with Schiff´s Bases
		2.2.3 Covalent Imprinting with Ketals and Acetals
	2.3 Semi-Covalent Imprinting
	2.4 Non-covalent Imprinting
		2.4.1 The Nature of the Pre-polymerization Complex
		2.4.2 Non-covalent Imprinting with a Single Functional Monomer
		2.4.3 Imprinting with Combinations of Monomers
		2.4.4 Custom-Designed Monomers
	2.5 Monomer Selection and Optimization Methods
		2.5.1 Combinatorial Approaches to Optimization
		2.5.2 Chemometric Methods
		2.5.3 Molecular Modeling Approaches
	References
Chapter 3: Special Control by Molecularly Imprinted Materials-Zero-Order Sustained Release, Enantioselective MIPs, and Self-Re...
	3.1 Molecularly Imprinted Materials-DDS for Zero-Order Sustained Release
	3.2 Enantioselective Drug Delivery System and the Application of MIP
		3.2.1 MIPs Used in Oral Drug Delivery Systems
		3.2.2 MIPs Used in Transdermal Drug Delivery Systems
	3.3 Self-Regulated Drug Delivery Microdevices Based on MIP
		3.3.1 Environment-Stimuli Responsive MIP
		3.3.2 Chemical-Stimuli Responsive MIP
		3.3.3 Application of MIPs in Target Drug Delivery System
		3.3.4 Application of MIPs in Drug Trap System
	3.4 Conclusion
	References
Chapter 4: Water Compatible Molecularly Imprinted Polymers
	4.1 pH-Sensitive Hydrogel-Based Molecularly Imprinted Polymers (HydroMIPs)
	4.2 Temperature-Sensitive Hydrogel-Based Molecularly Imprinted Polymers
	4.3 Cyclodextrins-Based Molecularly Imprinted Polymers
	References
Chapter 5: Stimuli Responsive Imprinted DDS
	5.1 Thermo-Responsive Drug Delivery System and the Application of MIP
	5.2 pH-Sensitive Hydrogel-Based Molecularly Imprinted Polymers
	5.3 Solvent-Responsive Floating Molecularly Imprinted Polymers
		5.3.1 Liquid Crystalline-Molecularly Imprinted Polymers for Gastroretentive Controlled Drug Release System
		5.3.2 Liquid Crystalline/Polyhedral Oligomeric Silsesquioxane Molecularly Imprinted Polymers for Gastroretentive Controlled Dr...
		5.3.3 Liquid Crystalline/Metal Organic Framework Molecularly Imprinted Polymers for Gastroretentive Controlled Drug Release Sy...
		5.3.4 Liquid Crystalline/Carbon Nanotubes Molecularly Imprinted Polymers for Gastroretentive Controlled Drug Release System
	5.4 Conclusion
	References
Chapter 6: MIP as Drug Delivery Systems for Dermal Delivery
	6.1 General Aspects of Transdermal Delivery System
	6.2 Analog Patch
		6.2.1 Nicotine Transdermal Patch Based on Bulk Polymerization
		6.2.2 Nicotine Transdermal Patch Based on Precipitation Polymerization
	6.3 Composite Imprinted Membrane
		6.3.1 Surface Grafting-Based MIP Composite Membrane
		6.3.2 Nanoparticle-on-Microsphere-Based MIP Composite Membrane
	6.4 Mungbean Starch/Biomaterial Imprinted Films
		6.4.1 The Synthesis of MBS/PVA Biomaterials Imprinted Films
		6.4.2 The Properties Evaluation of MBS/PVA Biomaterials Imprinted Films
		6.4.3 The Release Properties of MBS/PVA Biomaterials Imprinted Films
	6.5 Gel Reservoir-Type Transdermal Patch Based on Imprinted Membrane
		6.5.1 Construction of Reservoir Transdermal Patch
		6.5.2 Evaluation of the Transdermal Patch
	6.6 The Limitations and Outlook
	References
Chapter 7: MIP as Drug Delivery Systems of Anticancer Agents
	7.1 Active Targeting
	7.2 pH-Controlled Anticancer Drug Release with the Aid of MIP
	7.3 Stimuli-Responsive Imprinted DDS for Cancer Treatment
	7.4 Biocompatibility and Biodegradability of MIP-DDS
	7.5 In Vivo Evaluation of Imprinted DDS
	7.6 Conclusion
	References
Chapter 8: MIP as Drug Delivery Systems of Ophthalmic Drugs
	8.1 Sustained Release of Ophthalmic Drugs in Contact Lenses with Different Release Durations
		8.1.1 Introduce
		8.1.2 Antibacterials/Antibiotic
		8.1.3 Antifungals
		8.1.4 Dry Eye Disease
		8.1.5 Glaucoma
			8.1.5.1 Bimatoprost
			8.1.5.2 Timolol
			8.1.5.3 Acetazolamide and Ethoxazolamide
			8.1.5.4 Dorzolamide
		8.1.6 Inflammation
			8.1.6.1 Prednisolone Acetate
			8.1.6.2 Diclofenac Sodium
		8.1.7 Allergy
			8.1.7.1 Olopatadine
			8.1.7.2 Ketotifen
	8.2 The Entrapment of Biological Ophthalmic Drugs by MIP
	8.3 In Vivo Studies of Ophthalmic Drug-Imprinted Polymers
		8.3.1 Ciprofloxacin
		8.3.2 Bimatoprost
		8.3.3 Timlol
		8.3.4 Ketotife
	8.4 Conclusion
	References
Chapter 9: MIP as Drug Delivery Systems for Special Application
	9.1 Introduction
	9.2 MIP as Drug Delivery Systems for Intravenous Route
	9.3 Electromagnetic MIPs for Drug Delivery Systems
	9.4 MIP as Drug Delivery Systems of Gene Therapies
	9.5 Conclusions
	References
Chapter 10: Outlook
	10.1 Future Prospects-Improved Formats for Polymerization
	10.2 Future Prospects-Enhancing Site Accessibility
	10.3 Future Prospects-Post-polymerisation Modification of Polymers
	10.4 Conclusion
	References