Molecular Targets of CNS Tumors

preface_Molecular Targets of CNS Tumors......Page 1
part_ 1......Page 13
01_Genetic and Immunology of Brain Tumors......Page 15
02_Genetic Instability in Paediatric and Adult Brain Tumours......Page 31
03_Brain Tumor Exosomes and Microvesicles:
Pleiotropic Effects from Tiny Cellular
Surrogates......Page 55
04_Recurrent Malignant Primary Brain Tumor:
the Pathophysiology and Management......Page 91
part_ 2......Page 109
05_The Role of Sox Transcription Factors
in Brain Tumourigenesis......Page 111
part_ 3......Page 137
06_Angiogenesis of Primary Brain Tumors:
The Role of Endoglin (CD105)......Page 139
part_ 4......Page 153
07_The Role of Aquaporines in Brain Tumors......Page 155
part_ 5......Page 161
08_Glioma Stem Cells......Page 163
09_Molecular Hallmarks of Gliomas......Page 189
10_Integrated Network Analysis of Genetic and
Epigenetic Factors in Glioblastoma Multiform......Page 213
11_The Neural Extracellular Matrix, Cell Adhesion
Molecules and Proteolysis in Glioma Invasion
and Tumorigenicity......Page 251
12_Portrait of Transcriptional Expression Profiles
Displayed by Different Glioblastoma Cell Lines......Page 277
13_Genetics and Biology of
Glioblastoma Multiforme......Page 301
14_Chemokines in Glioma Progression......Page 327
15_Biomarkers of Glioma......Page 337
16_MicroRNA (miRNA) Regulation in Glioma:
Implications in Development, Progression,
Grading, Prognosis and Therapy......Page 355
17_MicroRNA
 in Human Gliomas......Page 375
part_ 6......Page 389
18_Gliomas: Role of Wnt/β-Catenin/
Tcf Signaling Pathway......Page 391
part_ 7......Page 405
19_Insulin-Like Growth Factor Binding Protein-2:
A Possible Regulator of Invasive
Growth in Glioblastoma......Page 407
part_ 8......Page 423
20_The Role of Isocitrate Dehydrogenase
Mutations in Glioma Brain Tumors......Page 425
part_ 9......Page 449
21_The Expression of BORIS Protein in a Newly
Established Primary Glioma Cell Culture Line......Page 451
part_ 10......Page 471
22_MiR-221/222 Promote the Growth of Malignant
Glioma Cells by Regulating Its Target Genes......Page 473
part_ 11......Page 495
23_Primary Glioblastoma with Different Patterns of
EGFR Amplification and the Relationship with
Gene Expression Profile......Page 497
24_Nuclear Signaling of EGFR and EGFRvIII
in Glioblastoma......Page 527
part_ 12......Page 549
25_Ap 1 in Glioblastomas......Page 551
part_ 13......Page 559
26_The Musashi1 RNA-Binding Protein:
A Critical Regulator in Glioblastoma......Page 561
part_ 14......Page 577
27_The Pivotal Roles of GSK3β in Glioma Biology......Page 579
part_ 15......Page 603
28_The Role of Matrix Metalloproteinases and
Tissue Inhibitors of Metalloproteinases in the
Progression of Astrocytomas......Page 605
part_ 16......Page 633
29_Medulloblastoma – Genetic Alterations......Page 635
part_ 17......Page 651
30_The Role of HGF/c-Met Pathway Signaling in
Human Medulloblastoma......Page 653
part_ 18......Page 673
31_The Impact of Redox Balance in Brain Tumors......Page 675