Molecular Oncology and Clinical Applications

Front Matter....Pages i-ix
Front Matter....Pages 1-1
The Impact of Molecular Genetics on Cancer Research....Pages 3-13
Identification of a Chimeric Gene Frequently Activated in Human Thyroid Papillary Carcinomas....Pages 15-23
The Role of Tumor Suppressor Genes in Human Cancer Progression....Pages 25-36
The Central Role of the IGF-1 Receptor in the Control of Cellular Proliferation....Pages 37-48
Loss of TGF-ß Expression is a Critical Component of Malignant Progression in Multistage Carcinogenesis of the Mouse Epidermis....Pages 49-57
Structure, Biosynthesis and Biochemical Properties of the HGF/SF Receptor....Pages 59-74
Molecular Characterization of Trop-2, a Cell Surface Molecule Highly Expressed by Human Carcinomas — Cloning of the Gene Encoding Trop-2....Pages 75-82
Loss of Heterozygosity and Distribution of Alleles at the VNTR Region of the HRAS Gene in Ovarian Carcinoma....Pages 83-87
Mg 2+ in the Regulation of Ascites Tumor Cell Energy Metabolism....Pages 89-94
Effect of Quercetin on Cell Proliferation and Heat Shock Protein Synthesis Induction in K562 Erythroleukemia....Pages 95-101
Regulation of MnSOD Expression by Manganese in Tumors....Pages 103-107
Front Matter....Pages 109-109
An Efficient Expression cDNA Cloning Approach to Screen Human Tumors for Oncogenes....Pages 111-122
The Roles of Specific Isoforms of Protein Kinase C (PKC) in Signal Transduction, Growth Control and Diacylglycerol Metabolism....Pages 123-128
Regulation of Protein Kinase C....Pages 129-136
Potential Roles of p21ras in Growth Factor Signalling — An Overview....Pages 137-139
p21-ras and p56-lck Mediate The Two Major T-Cell Antigen Receptor Signal Transduction Pathways....Pages 141-146
Further Characterization of CDC25 Mm , a Mammalian Activator of p21ras....Pages 147-151
MAP Kinase Cascade and the Control of Cell Proliferation....Pages 153-164
Accumulation and Mitogenic Activity of Lysophosphatidylinositol in k-ras-Transformed Thyroid Cells....Pages 165-171
Activities Involved in the Modulation of the G Protein Endogenous ADP-Ribosylation in Normal and K-ras-Transformed Thyroid Cells....Pages 173-180
Front Matter....Pages 109-109
The Regulation of TNF-α Receptors in Human Osteosarcoma Cells....Pages 181-189
Chronic Exposure to the Tumor Promoter TPA Mimics Differentiating Effects of Serum in Primary Cultures of Cerebellar Granules....Pages 191-196
Transcriptional Control by Nuclear Receptors....Pages 197-210
Front Matter....Pages 211-211
Therapeutic Opportunities Involving Cellular Oncogenes....Pages 213-222
Molecular Analysis of Fine Needle Aspiration Cytologic Specimens from Suspicious Thyroid Nodules....Pages 223-228
Tumor-associated Macrophages: Cytokine Regulation and Therapeutic Implications....Pages 229-234
Various Cytokines (IL-2, IL-4, IFN-gamma) Show Different Efficiency in Inducing Tumor Rejection....Pages 235-241
Adoptive Immunotherapy of Melanoma with Interleukin-2 and Lymphocytes....Pages 243-252
GM-CSF Augments the IL-4 Induced Cytotoxic Activity of Human Peripheral Blood Mononuclear Cells in the Presence of the Mouse Monoclonal Antibody 17–1A....Pages 253-259
Autologous Bone Marrow Transplantation with Peripheral Stem Cells In vivo Expanded by Chemotherapy and G-CSF....Pages 261-265
The Regulatory Subunit of cAMP-Dependent Protein Kinase as a Target for Cancer Diagnosis and Therapy....Pages 267-278
Type I Isoform of PKA is Involved in the Control of Cell Proliferation and Oncogene Transformation of Human Mammary Epithelial Cells: Therapeutic Implications....Pages 279-283
Modulation of the Cell Response to Hyperthermia by Membrane Perturbating Agents....Pages 285-290
MRS Studies on Experimental Tumours Treated with TNF....Pages 291-296
Tumor Vaccines — Perspectives and Practice....Pages 297-311
Front Matter....Pages 313-313
Tumor Imaging with Radiolabeled Monoclonal Antibodies and Other Specific Ligands....Pages 315-320
Evaluation of p53 Overexpression in Bladder Cancer....Pages 321-325
Biological Factors and Treatment Decision in Early Breast Cancer....Pages 327-334
New Chemotherapeutic Agents: A Selection of Some of the Most Promising New Drugs....Pages 335-346
Degradation of 5-Fluorouracil via the Pyrimidine Degradative Pathway....Pages 347-352
Front Matter....Pages 313-313
Folinic Acid and 5-Fluorouracil ± Interferon Alfa-2b in the Treatment of Advanced Colorectal Cancer: Preliminary Results of a Randomized Study....Pages 353-358
Pharmacokinetics of Free and Total Platinum Species after Prolonged Venous Infusion of Cisplatin and Concurrent Radiation Therapy for Lung Carcinoma....Pages 359-362
The Role of Interferons in the Treatment of Solid Tumors....Pages 363-374
Endocrine Treatment of Malignant Disease....Pages 375-383
Interactions Between Growth Factors and Oestrogens in Breast Cancer Cells....Pages 385-389
Potentiation of the Antitumor Activity of Tamoxifen by Interferons: A Mini-Review....Pages 391-394
Vitamin E status is Influenced by ω-3 Polyunsaturated Fatty Acid Supplementation in Patients at Risk for Colon Cancer....Pages 395-400
Progress Towards the Clinical Application of Somatic Cell Gene Therapy....Pages 401-410
Intraoperative Radiation Therapy: An Overview....Pages 411-428
Back Matter....Pages 429-437