Molecular Biology of Neuroreceptors and Ion Channels

Front Matter....Pages I-XXI
Common Structural Principles of Ion Channel Proteins....Pages 1-11
Brain and Muscle Nicotinic Acetylcholine Receptors: A Gene Family....Pages 13-30
The Gene Family Encoding Neuronal Acetylcholine Receptors: Structure of the Avian Alpha2 and Alpha3 Genes....Pages 31-36
Structure of Muscle and Neuronal Nicotinic Acetylcholine Receptors....Pages 37-53
Nicotinic Acetylcholine Receptors in the Nervous System of Insects....Pages 55-68
Ligand-Gated Ion Channels of Drosophila ....Pages 69-81
The Structure and Expression of the GABA A Receptor as Deduced by Molecular Genetic Studies....Pages 83-99
GABA A receptor: subunit expression in Xenopus oocytes and localization of receptor mRNAs in rat brain....Pages 101-117
Molecular Heterogeneity of GABA A -Benzodiazepine Receptors....Pages 119-124
The Postsynaptic Glycine Receptor — A Member of the Neurotransmitter-Gated Channel Protein Family....Pages 125-130
Immunological identification of a neonatal glycine receptor isotype and its expression in primary cultures of spinal cord....Pages 131-138
Glycine receptor regulation in rodent spinal cord....Pages 139-148
Expression-Cloning and Analysis of the Serotonin 1c Receptor from Mouse Brain....Pages 149-161
Cloned Serotonin 5HT-2 Receptor: Structure and Second Messenger Coupling....Pages 163-173
An Apparent New L-Glutamate Receptor in the Mammalian-Peripheral Nervous System....Pages 175-179
Molecular Properties of Voltage-Sensitive Sodium and Calcium Channels....Pages 181-200
Genetic and Molecular Analysis of a Gene Encoding Sodium Channels in Drosophila....Pages 201-214
A Family of Potassium Channels from the Shaker Locus of Drosophila ....Pages 215-229
Molecular Basis of Biological Diversity at the Shaker Locus of Drosophila....Pages 231-243
Common Properties of Receptors Coupled to GTP Binding Regulator Proteins....Pages 245-257
Cloning of a Rat D 2 -Dopamine Receptor cDNA....Pages 259-267
Molecular characterization of neuropeptide receptors and of a novel membrane protein involved in K + permeation....Pages 269-277
A 64 kDa protein is a candidate for a TRH receptor in prolactin-producing rat pituitary tumour cells....Pages 279-282
Comparison of the Presynaptic Vesicle Component Synaptophysin and Gap Junction Proteins: A Clue for Neurotransmitter Release?....Pages 283-289
Use of Synthetic Peptides and High Affinity Protein Ligands for Structural Studies of Central and Peripheral Nicotinic Receptors....Pages 291-309
Functional Domains of the Nicotinic Acetylcholine Receptor....Pages 311-320
The Limited Sequence Specificity of Anti-Peptide Antibodies may Introduce Ambiguity in Topological Studies....Pages 321-326
Structure, Conformation and Immunological Analysis of Peptide 188–201, the Putative Binding Site for α-Bungarotoxin in the α Subunit of Acetylcholine Receptor....Pages 327-343
Towards an Understanding and use of the Cholinergic Binding Site....Pages 345-352
Evidence for Multipoint Attachment of Ligands to the Nicotinic Acetylcholine Receptor....Pages 353-359
Fine Structural Characterization of the Main Immunogenic Region of the Nicotinic Acetylcholine Receptor....Pages 361-371
Phosphorylation of the Nicotinic Acetylcholine Receptor and Localization of Its Phosphorylation Sites....Pages 373-380
A New Bromobimane Fluorescent Label for Anion Exchange Proteins....Pages 381-391
Changes in Membrane Phosphoproteins Associated with the ATP Modulation of the Delayed Rectifier K + Channel in the Squid Giant Axon....Pages 393-399
Channel Modelling Experiments in Planar Bilayers Using Amphiphilic Helical Polypeptides....Pages 401-412
Structural and Dynamic Molecular Models for Sodium Channels....Pages 413-440
Processing, Assembly, and Ligand Binding of the Mouse Nicotinic Acetylcholine receptor Subunits in Stably Transfected Fibroblasts....Pages 441-449
Assembly and Insertion of a Multi-Subunit Nicotinic Acetylcholine Receptor into Plasma Membranes....Pages 451-467
Stable Expression of Multisubunit Protein Complexes in Mammalian Cells....Pages 469-480
Regulation of Acetylcholine Receptor Gene Expression During Development of the Neuromuscular Junction....Pages 481-507
Developmental Regulation of Acetylcholine Receptor-Subunit mRNA at the Rat Neuromuscular Junction....Pages 509-517
Myotube Specific Expression of the Mouse AChR Delta Subunit Gene is Conferred by 148 BP of 5′ Flanking DNA....Pages 519-540
Transcriptional Regulation of Acetylcholine Receptor Genes in Transfected Muscle Cells and Transgenic Mice....Pages 541-552
The Intermediate Lobe of the Pituitary: A Model for Studying Mechanisms of Trans-Synaptic Regulation of Specific Gene Expression....Pages 553-563
Positive Modulators of Acetylcholine Receptor: Differences Between Skeletal Muscle and Electric Organ....Pages 565-584
Localisation of Muscarinic Acetylcholine Receptors in Cat Visual Cortex During Postnatal Development....Pages 585-593
Regulation of Cortical Muscarinic Acetylcholine Receptors: Involvement of Potassium Channels....Pages 595-617
Regulation of Calcium Channels and Adenylate Cyclase by Opiates....Pages 619-631
Transdifferentiation to a Neuronal Phenotype in Adult Bovine Chromaffin Cells: Effects of αMSH, bFGF and Histamine....Pages 633-644
Molecular Biology of Neuroreceptors: Implications for Clinical Neuroscience....Pages 645-659
Back Matter....Pages 661-678