Molecular Biology of B Cells

Cover Page......Page 1
Inside Cover......Page 4
Copyright......Page 5
Contributors......Page 6
Contents......Page 8
Preface......Page 14
1. Human Immunoglobulin Heavy Chain Locus......Page 16
2. Immunoglobulin Heavy Chain Genes of Mouse......Page 34
3. Immunoglobulin k Genes of Human and Mouse......Page 42
4. Immunoglobulin Lambda (IGL) Genes of Human and Mouse......Page 52
5. The Mechanism of V(D)J Recombination......Page 76
6. Transcription of Immunoglobulin Genes......Page 98
7. Early B Cell Development to a Mature, Antigen-Sensitive Cell......Page 116
8. Allelic Exclusion, Isotypic Exclusion, and the Developmental Regulation of V(D)J Recombination......Page 142
9. The Development of Human B Lymphocytes......Page 156
10. Development and Function of B Cell Subsets......Page 170
11. Structure and Function of B Cell Antigen Receptor Complexes......Page 176
12. Regulation of Antigen Receptor Signaling by the Co-Receptors, CD19 and CD22......Page 186
13. The Dynamic Structure of Antibody Responses......Page 202
14. Dynamics of B Cell Migration to and within Secondary Lymphoid Organs......Page 218
15. Characteristics of Mucosal B Cells with Emphasis on the Human Secretory Immune System......Page 238
16. The Cellular Basis of B Cell Memory......Page 262
17. Immunoglobulin Assembly and Secretion......Page 276
COLOR PLATES......Page 289
18. Fc and Complement Receptors......Page 314
19. Regulation of Class Switch Recombination......Page 328
20. Molecular Mechanism of Class Switch Recombination......Page 346
21. Molecular Mechanism of Hypermutation......Page 366
22. Selection During Antigen-Driven B Cell Immune Responses: The Basis for High Affinity Antibody......Page 378
23. Chromosomal Translocations in B-Cell Leukemias and Lymphomas......Page 388
24. Classification and Characteristics of Mouse B Cell–Lineage Lymphomas......Page 404
25. B Cells Producing Pathogenic Autoantibodies......Page 420
26. Immunodeficiencies Caused by B-Cell Defects......Page 442
27. Diverse Forms of Immunoglobulin Genes in Lower Vertebrates......Page 456
28. Immunoglobulin Genes and Generation of Antibody Repertoires in Higher Vertebrates: A Key Role for GALT......Page 472
29. The Zebrafish Immune System......Page 488
30. The Origin of V(D)J Diversification......Page 512
31. Antibody Structure and Recognition of Antigen......Page 530
32. Monoclonal Antibodies from Display Libraries......Page 550
33. Humanization of Monoclonal Antibodies......Page 572
34. Human Monoclonal Antibodies from Translocus Mice......Page 586
Index......Page 602