Molecular Basis of Membrane-Associated Diseases

Front Matter....Pages I-XII
Front Matter....Pages 1-1
Insulin Receptor Kinase and Insulin Action....Pages 3-13
Structural and Functional Aspects of Signal Transduction by Receptor Tyrosine Kinases....Pages 14-21
Nerve Growth Factor (NGF): Physiological Functions and Regulation of Its Synthesis....Pages 22-28
Signal Transduction by Growth Factor Receptors....Pages 29-34
Altered Regulation of Receptor-Associated Tyrosine Kinases in Human Tumors....Pages 35-52
The Role of Plasma Membrane Phospholipids in Cellular Pathology....Pages 53-63
Changes in the Structure and Function of the Red Cell Membrane Skeleton and Hemolytic Anemias....Pages 64-70
Regulation of Intracellular Ca 2+ in Pancreatic Acinar Cells by Membrane Pumps and Channels....Pages 71-83
Control of Protein Kinase C Function by Activators and Inhibitors....Pages 84-96
Front Matter....Pages 97-97
K+ Channels: Structure, Function, Regulation, Molecular Pharmacology and Role in Diseased States....Pages 99-111
Voltage-Dependent Calcium Channels: Structure and Regulation in Normal and Abnormal States....Pages 112-123
Cell Membrane Abnormalities in Genetic Hypertension....Pages 124-129
Transmembrane Cation Transport: An Approach to the Study of the Molecular Basis of Hypertension....Pages 130-133
Transmembrane Ionic Fluxes in the Brain in Energy-Depleted Cells....Pages 134-153
Front Matter....Pages 155-155
Mitochondrial Diseases....Pages 157-166
Mitochondrial Myopathy: Biochemical Approaches to Respiratory Chain-Linked Electron Transfer and Energy Coupling....Pages 167-182
Phosphorus Magnetic Resonance Spectroscopy ( 31 P NMR) as a Tool for in Vivo Monitoring of Mitochrondrial Muscle Disorders....Pages 183-199
Cytochemical and Immunocytochemical Studies of Human Mitochondrial Myopathies....Pages 200-215
Regulatory Complexity of Cytochrome c Oxidase and Its Defective Manifestation in Mitochondrial Diseases....Pages 216-227
Fibroblasts and Cytochrome c Oxidase Deficiency....Pages 228-238
Front Matter....Pages 155-155
Human Cytochrome c Oxidase Deficiencies; Structural and Functional Aspects....Pages 239-253
Front Matter....Pages 255-255
Brown Adipose Tissue, Diet-Induced Thermogenesis and Genetic Obesity....Pages 257-264
Acute and Long-Term Regulation of Brown Adipose Tissue Thermogenesis: Physiological and Pathological Implications....Pages 265-284
Molecular Composition, Fluidity of Membranes and Functional Properties of Human Liver Mitochondria and Microsomes....Pages 285-302
Changes in Erythrocyte and Platelet Membrane Fluidity in Childhood Obesity....Pages 303-308
Skeletal Muscle Mitochondria and Phospholipase Activity in Malignant Hyperthermia....Pages 309-322
The Antimitochondrial Antibodies (AMA) of Primary Biliary Cirrhosis (PBC)....Pages 323-334
Toxicity, Antioxidants, and Metabolism....Pages 335-343
Front Matter....Pages 345-345
Mitochondrial H-ATP Synthase Under Normal and Pathological Conditions....Pages 347-358
Antitumor Effect of Drugs Interfering with Mitochondrial Biogenesis....Pages 359-367
Front Matter....Pages 369-369
The Complex of β-Galactosidase, Neuraminidase and “Protective Protein” in Lysosomes: Molecular Characterization of the “Protective Protein”....Pages 371-378
The Role of Activator Proteins in Glycolipid Degradation and Storage Diseases....Pages 379-394
Solute Translocation Across the Lysosome Membrane: Physiology, Pathology and Pharmacology....Pages 395-406
The Peroxisomal β-Oxidation Systems: Characteristics and (Dys) Functions in Man....Pages 407-419
Genetic Heterogeneity in Inherited Disorders with a Generalized Impairment of Peroxisomal Functions: Visualization by Immunofluorescence Microscopy of Peroxisome Assembly After Somatic Cell Fusion of Complementary Cell Lines....Pages 420-428
Back Matter....Pages 429-435