Molecular Aspects of Oxidative Drug Metabolizing Enzymes: Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health

Front Matter....Pages I-IX
Introduction to Cytochrome P450....Pages 1-19
General Aspects of NADPH Cytochrome P450 Reductase and Cytochrome b5....Pages 21-45
Interaction Between Cytochrome P450 and Reductase....Pages 47-63
Molecular Biology of Cytochrome P-450: Evolution, Structure and Regulation....Pages 65-85
The Role of Nuclear Receptors in the Regulation of P450s and Other Genes by Peroxisome Proliferators....Pages 87-103
Mapping Determinants of the Substrate Specificities of P450s by Site-Directed Mutagenesis....Pages 105-134
Diversity and Regulation of Cytochromes P450 in Aquatic Species....Pages 135-158
Cytochrome P450 Expression in Rainbow Trout: An Overview....Pages 159-180
Molecular Aspects of Cytochrome P450 2E1 and Its Roles in Chemical Toxicity....Pages 181-192
Problems Associated with Assessment of the Contribution of Individual Forms of Cytochrome P450 to the Metabolism of Xenobiotics....Pages 193-207
Emergence of the Flavin-Containing Monooxygenase Gene Family: Molecular Biology, Structure, and Function....Pages 209-224
Flavin-Containing Monooxygenases: Substrate Specificity and Complex Metabolic Pathways....Pages 225-235
Developmental Regulation of Biotransformation of Drugs and other Xenobiotics....Pages 237-248
Modulation of Xenobiotic Metabolism and Toxicity by Dietary Chemical....Pages 249-259
Mechanisms of Mutagenicity and Tumour Formation....Pages 261-302
Genotoxicity assays....Pages 303-396
Use of Mechanistic Information for Adequate Metabolic Design of Genotoxicity Studies and Toxicological Interactions of Drugs and Environmental Chemicals....Pages 397-409
Significance of Posttranslational Modification of Drug Metabolizing Enzymes by Phosphorylation for the Control of Carcinogenic Metabolites....Pages 411-427
The Construction of Cell Cultures Genetically Engineered for Metabolic Competence towards Xenobiotics....Pages 429-454
In Vitro Systems as Analytical Tools for Understanding and Predicting Drug Metabolism In Vivo....Pages 455-460
The Role of Oxidative Enzymes in the Metabolism and Toxicity of Pesticides....Pages 461-478
Metabolism of Xenobiotic Proestrogens and Estrogens by Cytochrome P450....Pages 479-489
Metabolism of Antiestrogenic Anti-Cancer Agents by Cytochromne P450 and Flavin-Containing Monooxygenases. Mechanism of Action Involving Metabolites....Pages 491-502
Therapeutic Agents and Cytochrome P450....Pages 503-513
Drug Metabolism, Lipid Peroxidation and Glutathione....Pages 515-532
Health Environment of Altai Territory and Monooxygenase and Conjugating Activities in Placentae of Newborn....Pages 533-548
Monooxygenase Measurements as Indicators of Pollution in the Field....Pages 549-565
Biochemical and Genotoxicological Monitoring of Ecosystems with Special Reference to Lake Baikal and Northern Black Sea....Pages 567-589
Relating Biochemical Responses to “Higher Order” Effects....Pages 591-603
Back Matter....Pages 605-620