Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds

Front Matter....Pages i-ix
Cytochrome P450-Dependent Monooxygenase: An Overview....Pages 1-10
The Flavin-Containing Monooxygenase (EC 1.14.13.8)....Pages 11-21
Multiple Forms of Rabbit Cytochrome P450: Comparison of Chemical Physical, Immunological and Biocatalytic Properties....Pages 23-54
Primary Structures and Regulation of Cytochrome P-450 Isozymes 2 (IIB) And 5 (IVB) and the Flavin-Containing Monooxygenase in Rabbit Liver and Lung....Pages 55-73
Insect Cytochrome P450....Pages 75-91
Membrane Topology of Cytochromes P-450: Elements and Measurement by Spectroscopic Techniques....Pages 93-113
Membrane Topology of Cytochromes P-450: Oligomers and Cooperativity....Pages 115-133
NADPH-Dependent Cytochrome P450 Reductase....Pages 135-147
Essential Features of NADH Dependent Cytochrome b5 Reductase and Cytochrome b5 of Liver and Lung Microsomes....Pages 149-170
Electron Transfer from Cytochrome b5 to Cytochrome P450....Pages 171-183
Functional Aspects of Protein-Protein Interactions of Cytochrome P450 Cytochrome b 5 and Cytochrome P450 Reductase....Pages 185-198
Posttranslational Modification by Phosphorylation: Control of Cytochrome P450 and Associated Enzymes....Pages 199-232
Physiological and Pathophysiological Alterations in Rat Hepatic Cytochrome P-450+....Pages 233-253
Ontogenesis of Liver Cytochromes P450....Pages 255-266
Mechanism of Steroid Hormone Action....Pages 267-281
Xenobiotic Regulation of Cytochrome P-450 Gene Expression....Pages 283-292
Prostanoid Metabolism and Biologically Active Product Formation....Pages 293-304
Role of Cytochrome P - 450 in the Anabolism and Catabolism of Endobiotics....Pages 305-330
Interactions of Estrogenic Pesticides with Cytochrome P450....Pages 331-344
Effects of Inhibitors on the P450-Dependent Metabolism of Endogenous Compounds in Fungi, Protozoa, Plants and Vertebrates....Pages 345-363
Mechanism of Metabolic Activation of Nitroimidazoles....Pages 365-374
Benzene Metabolism....Pages 375-386
Mechanisms of Benzene Toxicity....Pages 387-414
Hematotoxicity, Leukemogenecity and Carcinogenecity of Chronic Exposure to Benzene....Pages 415-434
Epoxide Hydrolase Isoenzymes and their Individual Contribution to the Control of Toxic Metabolites....Pages 435-445
Role of the Well-Known Basic and the Recently Discovered Acidic Glutathione S-Transferases in the Control of Genotoxic Metabolites....Pages 447-461
Characterisation and Regulation of UDP-Glucuronosyltransferases....Pages 463-472
Molecular Cloning, Expression and Genetic Deficiencies Of UDP-Glucuronosyltransferases....Pages 473-487
Back Matter....Pages 489-497