Molecular and Cellular Mechanisms of H+ Transport

Front Matter....Pages I-X
Gene Structure and Regulation of Gastric Proton Pump....Pages 1-10
The Gastric H/K ATPase β Subunit Gene and Transcriptional Pathways in Acid-Secreting Epithelia of the Stomach and Kidney....Pages 11-18
Functional Expression of Gastric H,K-ATPase in Sf9 Cells using the Baculovirus Expression System....Pages 19-26
Structural and Functional Integrity of H,K-ATPase Depends β-Subunit....Pages 27-34
The Topology of the α, β Subunits of the Gastric H/K ATPase....Pages 35-53
Synthetic Peptide Antibody Probes of Membrane Orientation of the Gastric H,K-ATPase....Pages 55-62
Molecular Determinants of Subunit Assembly and Processing in Na,K-ATPase and H,K-ATPase....Pages 63-69
Assembly of Hybrid Pumps from Na,K-ATPase α Subunits and the H,K-ATPase β Subunit....Pages 71-78
DCCD Inhibition of Cation Binding in the Gastric H,K-ATPase....Pages 79-87
Mapping of a Cytoplasmic Site of Gastric (H + ,K + )-ATPase involved in the Transmission of K + -Activation across the Membrane....Pages 89-94
New Approaches to Inhibition of Gastric Acid Secretion: Development and Mechanism of Omeprazole....Pages 95-102
K + -Competitive Inhibitors of the Gastric (H + +K + )-Atpase....Pages 103-110
Bioactive Peptide Inhibitors and An Endogenous Parietal Cell Protein: Interactions With the Gastric H + /K + ATPase....Pages 111-118
The Gastric H/K-ATPase: The Principle Target in Autoimmune Gastritis....Pages 119-126
Acidic and non-acidic endosomes in kidney epithelial cells: their role in cell-specific membrane recycling processes....Pages 127-136
Regulation and Properties of the Coated Vesicle Proton Pump....Pages 137-144
Characterization of the Osteoclast Vacuolar H + ATPase: Biochemistry, Subunit Composition and Cloning of Catalytic Subunits....Pages 145-151
The Renal H-K-ATPase: Function and Expression....Pages 153-161
Apical K + -ATPase and Active Potassium Absorption in the Distal Colon....Pages 163-171
Amino Acid Residues Involved in Ouabain Sensitivity and Cation Binding....Pages 173-179
The Use of Site-Directed Mutagenesis to Identify Functional Sites in the Ca 2+ ATPase....Pages 181-190
Structure-Function Relationships in Transmembrane Segment IV of the Yeast Plasma Membrane [H + ]-ATPase....Pages 191-197
The role of two small proteolipids associated to the H + -ATPase from yeast plasma membrane....Pages 199-204
Ion Translocation Stoichiometries of Two Endomembrane H + -Pumps Studied by Patch Clamp....Pages 205-212
Molecular Dissection of Vacuolar H+-Pyrophosphatase....Pages 213-220
F-type H + -ATPase: Catalysis and Proton Transport....Pages 221-228
Contribution of infrared spectroscopy to the understanding of the structure of the Neurospora crassa plasma membrane H + -ATPase....Pages 229-236
Partial Reaction Chemistry and Charge Displacement by the Fungal Plasma-Membrane H + -Atpase....Pages 237-244
Molecular Properties, Kinetics And Regulation Of Mammalian Na + /H + Exchangers....Pages 245-260
Polarized Na/H exchangers in colonic epithelium: a problem of balance....Pages 261-266
The AE gene family of band 3-related anion exchangers....Pages 267-273
Proton-coupled peptide transport in the small intestine and kidney....Pages 275-282
H + -coupled solute transport in cultured intestinal epithelia....Pages 283-296
Measurement of H + and Ca 2+ extrusion from single isolated cells....Pages 297-300
CFTR Chloride Channels and Pancreatic Ductal Bicarbonate Secretion....Pages 301-308
Acute Regulation of Na + :HCO 3 - Cotransport System In Kidney Proximal Tubules....Pages 309-317
Potassium dependent H + /HCO 3 - transport mechanisms in cells of medullary thick ascending limb of rat kidney....Pages 319-327
Characterization of Parietal Cell Functional Morphology Utilizing Isolated Gastric Gland Perfusion, Atomic Force and Confocal Microscopy....Pages 329-339
Activation of calpain in gastric parietal cells....Pages 341-349
Stimulation of Gastric Acid Secretion Causes Actin Filament Formation and Development of the Secretory Surface in Frog Oxynticopeptic Cells....Pages 351-358
Expression of rat gastric H + , K + -ATPase in insect cells using a double recombinant baculovirus....Pages 359-366
Influence of F-Actin on Na + /K + /2CI - Cotransport in Cultured Intestinal Epithelia....Pages 367-373
Ca 2+ Pools and H + Secretion by the Parietal Cell....Pages 375-382
Acidophylic CI - and K + Channels of the Gastric Parietal Cell: A New Model of Regulated HCI Secretion....Pages 383-390
Uncoupling of H + and Pepsinogen Secretion in the Amphibian Oxyntopeptic Cell....Pages 391-399
The Canine Gastric Muscularis Mucosae and Acid Secretion: A Basket Case?....Pages 401-414
The Receptors Regulating Acid Secretion on and off the Parietal Cell....Pages 415-422
Post-Receptor Signaling Mechanisms in the Gastric Parietal Cell....Pages 423-430
Relative Sensitivity to Acid Injury of Different Regions of the Intestinal Tract....Pages 431-438
“First-Pass” Protection Against Luminal Acid in Necturus Antral Epithelium....Pages 439-446
Regulation of pHi in Oxyntic Cells in Intact Sheets of Frog Gastric Mucosa....Pages 447-454
Oxyntic cell Na + /H + and CI - /HCO 3 - exchangers....Pages 455-463
Duodenal Mucosal Bicarbonate Secretion in Humans....Pages 465-473
Gastric bicarbonate secretion....Pages 475-482
Role of Dopamine in Control of Duodenal Mucosal Bicarbonate Secretion....Pages 483-490
Back Matter....Pages 491-497