Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors

Front Matter....Pages N2-xii
Somatomedins: A New Look at Old Questions....Pages 1-4
Autocrine and Paracrine Effects of the Somatomedins/Insulin-Like Growth Factors....Pages 5-23
Role of IGFs in Growth Hormone Homeostasis....Pages 25-37
Interaction of IGF with the Hypothalamus and Pituitary....Pages 39-56
Feedback Regulation of Growth Hormone Gene Expression by Insulin-like Growth Factor I....Pages 57-71
Growth Hormone and IGF Abnormalities of the African Pygmy....Pages 73-80
Somatomedin Inhibitors....Pages 81-95
The Structure and Expression of the Human Insulin-Like Growth Factor Genes....Pages 97-105
Transcriptional Diversity in Rat Insulin-Like Growth Factor I Gene Expression....Pages 107-116
Physiological Regulation of Insulin-Like Growth Factor Expression....Pages 117-124
Dietary and Hormonal Factors Affecting the mRNA Level of IGF-I in Rat Liver in vivo and in Primary Cultures of Rat Hepatocytes....Pages 125-128
Expression of IGF-I in Liver....Pages 129-139
Ovarian Insulin-Like Growth Factor I: Basic Concepts Leading to Potential Clinical Outlets....Pages 141-151
Regulation of Insulin-Like Growth Factor-1 Gene Expression by Estrogen....Pages 153-168
Regulation of IGF-II Gene Expression in Human Adrenals, Gonads and Placenta....Pages 169-178
Expression of Insulin-Like Growth Factors by the Human Placenta....Pages 179-193
IGFs in Pregnancy: Developmental Expression in Uterus and Mammary Gland and Paracrine Actions during Embryonic and Neonatal Growth....Pages 195-208
Hormonal Feedback Regulation of Brain IGF-I and IGF-II Gene Expression....Pages 209-217
Expression of the IGF-II Gene in Brain and Muscle....Pages 219-229
Regulation of the Neuronal Insulin-Like Peptide....Pages 231-235
Growth Regulation of Human Breast Cancer by Insulin-Like Growth Factors....Pages 237-245
Insulin-Like Growth Factors in Lung Cancer Cell Lines....Pages 247-260
Structural Basis for Ligand-Dependent Transmembrane Signalling of the Insulin and IGF-1 Receptor Kinases....Pages 261-284
Identification of the Domains of IGF I which Interact with the IGF Receptors and Binding Proteins....Pages 285-296
Comparison of Insulin-Like Growth Factor Receptors in Human Retinal Cells....Pages 297-308
IGF I Receptor Phosphorylation....Pages 309-314
Regulation of Growth Factor Receptors by Protein Kinase C....Pages 315-325
Insulin and Insulin-Like Growth Factor I Mediated Phosphorylations in Mouse Neuroblastoma N18 Cells: A Model for Studying Insulin and IGF-I Action on Neural Tissue....Pages 327-339
Insulin-Like Growth Factor Receptors in the Central Nervous System: Phosphorylation Events and Cellular Mediators of Biological Function....Pages 341-358
The Insulin-Like Growth Factor-II/Mannose 6-Phosphate Receptor....Pages 359-367
The Insulin-Like Growth Factor-II/Mannose 6-Phosphate Receptor....Pages 369-380
The Role of Insulin-Like Growth Factor Binding Proteins in Controlling the Expression of IGF Actions....Pages 381-394
Characterization and Cloning of a Rat Insulin-Like Growth Factor Binding Protein....Pages 395-402
Neurotrophic Effects and Mechanism of Insulin, Insulin-Like Growth Factors, and Nerve Growth Factor in Spinal Cord and Peripheral Neurons....Pages 403-425
Insulin-Like Growth Factors as Regulatory Peptides in the Adult Rat Brain....Pages 427-434
Receptors for Insulin and Insulin-Like Growth Factors I and II in PCD Mice and Diabetic Rats are Unaltered: An Autoradiographic Study....Pages 435-442
Insulin-Like Growth Factors and Heart Development....Pages 443-458
Role of Insulin-Like Growth Factor I And II on Skeletal Remodeling....Pages 459-466
Effects of Insulin-Like Growth Factors on Chromaffin Cells....Pages 467-472
Interactions of Insulin and IGFS with Cellular Components of the Arterial Wall: Potential Impact on Atherosclerosis....Pages 473-484
Interactions of Insulin-Like Growth Factor-I (IGF-I) with Multiple Signal Transduction Pathways in FRTL5 Thyroid Follicular Cells....Pages 485-493
Back Matter....Pages 495-511