Modeling the Psychopathological Dimensions of Schizophrenia From Molecules to Behavior

Content: 
Front Matter Page iii  
Copyright Page iv  
Contributors Pages xi-xiii  
Preface Page xv  
Chapter 1 - Overview of Schizophrenia: Dimensions of Psychopathology Pages 5-15 Arsime Demjaha, Robin M. Murray 
Chapter 2 - A Review of the Epidemiology of Schizophrenia Pages 17-30 Alan S. Brown, Florence S. Lau 
Chapter 3 - Modeling Dimensions of Psychopathology: Integration with the Epidemiology and Pathobiology of Psychotic Illness Pages 33-38 John L. Waddington 
Chapter 4 - Modeling the Positive Symptoms of Schizophrenia Pages 39-54 Tursun Alkam, Toshitaka Nabeshima 
Chapter 5 - Animal Models of Psychotic Disorders: Dimensional Approach Modeling Negative Symptoms Pages 55-67 Brian P. Kirby 
Chapter 6 - Modeling Cognitive Impairment Pages 69-84 Francesca Managó, Huiping Huang, Papaleo Francesco 
Chapter 7 - Modeling Affective Symptoms of Schizophrenia Pages 85-102 Luka Culig, Catherine Belzung 
Chapter 8 - Dysregulation of Dopamine Systems in a Developmental Disruption Model of Schizophrenia: Implications for Pathophysiology, Treatment, and Prevention Pages 107-124 Sofia M. Dibble, Yijuan Du, Anthony A. Grace 
Chapter 9 - Social Isolation Rearing and Sensorimotor Gating in Rat Models of Relevance to Schizophrenia: What We Know, and What We Do Not Know Pages 125-138 Susan B. Powell, Neal R. Swerdlow 
Chapter 10 - Glutamate Pharmacological Models Relevant to Schizophrenia and Psychosis: Can a Receptor Occupancy Normalization Approach Reduce the Gap between Animal and Human Experiments? Pages 139-174 Mark Rafter, Kevin CF. Fone, Paula M. Moran 
Chapter 11 - Modeling the Maternal Immune Activation Risk Factor for Schizophrenia Pages 175-191 Natalia Malkova, Wei-Li Wu, Elaine Y. Hsiao 
Chapter 12 - Etiological Environmental Models: Virus Infection Models Pages 193-207 Håkan Karlsson 
Chapter 13 - Toward a Diathesis-Stress Model of Schizophrenia in a Neurodevelopmental Perspective Pages 209-224 A. Berry, F. Cirulli 
Chapter 14 - The Toxoplasma gondii Model of Schizophrenia Pages 225-241 Joanne P. Webster, Poppy H.L. Lamberton, Glenn A. McConkey 
Chapter 15 - Maternal Nutritional Deficiencies and Schizophrenia: Lessons from Animal Models with a Focus on Developmental Vitamin D Deficiency Pages 243-264 Darryl W. Eyles, Angela J. Dean 
Chapter 16 - Mouse Models of Schizophrenia: Risk Genes Pages 267-284 Lieve Desbonnet 
Chapter 17 - Dimensional Deconstruction and Reconstruction of CNV-Associated Neuropsychiatric Disorders Pages 285-302 Noboru Hiroi, Akira Nishi 
Chapter 18 - Genetic Rat Models for Schizophrenia Pages 303-324 Bart A. Ellenbroek, Tim Karl 
Chapter 19 - Modeling Gene–Gene Interactions in Schizophrenia Pages 327-343 E. Von Cheong, Colm M.P. O’Tuathaigh 
Chapter 20 - Modeling Gene–Environment Interaction in Schizophrenia Pages 345-360 Yan Jouroukhin, Ross McFarland, Yavuz Ayhan, Mikhail V. Pletnikov 
Chapter 21 - Rodent Models of Multiple Environmental Exposures with Relevance to Schizophrenia Pages 361-371 Urs Meyer 
Chapter 22 - Synaptic Abnormalities and Neuroplasticity: Molecular Mechanisms of Cognitive Dysfunction in Genetic Mouse Models of Schizophrenia Pages 375-390 Ruoqi Gao, Theron A. Russell, Peter Penzes 
Chapter 23 - hiPSC Models Relevant to Schizophrenia Pages 391-406 Brigham J. Hartley, Yoav Hadas, Kristen J. Brennand 
Chapter 24 - Alternative Human Cell Models for Neuropsychiatric Research: Induced Neuronal Cells, Olfactory Epithelium, and Related Resources Pages 407-422 Brian Lo, Daniel Chang, Shin-ichi Kano 
Chapter 25 - Astrocytes as Pharmacological Targets in the Treatment of Schizophrenia: Focus on Kynurenic Acid Pages 423-443 Ana Pocivavsek, Francesca M. Notarangelo, Hui-Qiu Wu, John P. Bruno, Robert Schwarcz 
Chapter 26 - Dimensions of GSK3 Monoamine-Related Intracellular Signaling in Schizophrenia Pages 447-462 Gohar Fakhfouri, Jivan Khlghatyan, Ilya Sukhanov, Raul R. Gainetdinov, Jean-Martin Beaulieu 
Chapter 27 - Hormones and Schizophrenia Pages 463-480 Jayashri Kulkarni, Emmy Gavrilidis, Roisin Worsley 
Chapter 28 - Role of Redox Dysregulation in White Matter Anomalies Associated with Schizophrenia Pages 481-500 Aline Monin, Margot Fournier, Philipp S. Baumann, Michel Cuénod, Kim Q. Do 
Chapter 29 - Role of Immune and Autoimmune Dysfunction in Schizophrenia Pages 501-516 Emily G. Severance, Robert H. Yolken 
Chapter 30 - Future Directions Pages 517-518 Mikhail V. Pletnikov, John L. Waddington 
Index Pages 519-531