mODa 9 – Advances in Model-Oriented Design and Analysis: Proceedings of the 9th International Workshop in Model-Oriented Design and Analysis held in Bertinoro, Italy, June 14-18, 2010

Front Matter....Pages i-xxv
Impact of Stratified Randomization in Clinical Trials....Pages 1-8
The Non-Uniqueness of Some Designs for Discriminating Between Two Polynomial Models in One Variable....Pages 9-16
Covariate Adjusted Designs for Combining Efficiency, Ethics and Randomness in Normal Response Trials....Pages 17-24
Split-Plot and Robust Designs: Weighting and Optimization in the Multiple Response Case....Pages 25-32
An Improvement in the Lack-of-Fit Optimality of the (Absolutely) Continuous Uniform Design in Respect of Exact Designs....Pages 33-39
Optimal Allocation Proportion for a Two-Treatment Clinical Trial Having Correlated Binomial Responses....Pages 41-48
Sample Size Determination for Multivariate Performance Analysis with Complex Designs....Pages 49-55
Optimal Design for Compositional Data....Pages 57-64
Dose Finding Experiments: Responses of Mixed Type....Pages 65-72
Pharmacokinetic Studies Described by Stochastic Differential Equations: Optimal Design for Systems with Positive Trajectories....Pages 73-80
On Testing Hypotheses in Response-Adaptive Designs Targeting the Best Treatment....Pages 81-88
Towards Gaussian Process-based Optimization with Finite Time Horizon....Pages 89-96
Optimal Designs for Linear Logistic Test Models....Pages 97-104
A Class of Screening Designs Robust to Active Second-Order Effects....Pages 105-112
D-Optimal Design for a Five-Parameter Logistic Model....Pages 113-120
Sequential Barycentric Interpolation....Pages 121-128
Some Considerations on the Fisher Information in Nonlinear Mixed Effects Models....Pages 129-136
Designs with High Breakdown Point in Nonlinear Models....Pages 137-144
A Note on the Relationship between Two Approaches to Optimal Design under Correlation....Pages 145-148
The Role of the Nugget Term in the Gaussian Process Method....Pages 149-156
A Bonferroni-Adjusted Trend Testing Method for Excess over Highest Single Agent....Pages 157-164
Asymptotic Properties of Adaptive Penalized Optimal Designs over a Finite Space....Pages 165-172
Filling and D-optimal Designs for the Correlated Generalized Exponential Model....Pages 173-180
Designs for Dose Finding Studies on Safety and Efficacy....Pages 181-188
A Radial Scanning Statistic for Selecting Space-filling Designs in Computer Experiments....Pages 189-196
Optimal Designs for Two-Colour Microarray Experiments for Estimating Interactions....Pages 197-204
Discrimination Between Random and Fixed Effect Logistic Regression Models....Pages 205-212
Estimation and Optimal Designing under Latent Variable Models for Paired Comparisons Studies via a Multiplicative Algorithm....Pages 213-220
Pointwise Consistency of the Kriging Predictor with Known Mean and Covariance Functions....Pages 221-228
Information in a Two-stage Adaptive Optimal Design for Normal Random Variables having a One Parameter Exponential Mean Function....Pages 229-236
Back Matter....Pages 237-239