Mitochondrial signaling in health and disease

 Content: Mitochondria-Reactive Oxygen Species (ROS)-Cell Death A Healthy Free Radical Pessimism: A Glance from an Oxidative Lipidomics Corner; V. E. Kagan, A. A. Shvedova, and Y. Y. Tyurina Mitochondrial Involvement in the Execution of Cell Death; V. Gogvadze, B. Zhivotovsky, and S. Orrenius The Role of Protein Kinase C in Mitochondrial Functions in Cardiac Ischemia- Reperfusion Injury; J. C. B. Ferreira and D. Mochly-Rosen Mitocans, Mitochondria-Targeting Anticancer Drugs: Focus on Mitochondrial Complexes; J. Neuzil, L.-F. Dong, and J. Rohlena Therapeutic Potential of Lipoamide and Enhanced Mitochondrial Biogenesis for Treatment of Insulin Resistance; W. Shen, D. A. Carlson, L. Packer, E. Cadenas, and J. Liu Mitochondria-Targeted Antioxidants; R. A. J. Smith, R. C. Hartley, and M. P. Murphy  Mitochondria-Metabolism-Nitric Oxide Lactate Shuttling and the Mitochondrial Lactate Oxidation Complex; G. A. Brooks Nitric Oxide in the Regulation of Mitochondrial Biogenesis; C. De Palma and E. Clementi Effect of Sildenafil on Heart Nitric Oxide Metabolism and Mitochondrial Function; T. Zaobornyj, L. B. Valdez, and A. Boveris Kinases and Mitochondrial Cycling: The Last Encounter; M. C. Carreras and J. J. Poderoso  Acetylation-Deacetylation-Aging Nuclear Chromatin Factors Defining Mitochondrial Bioenergetics: Implications in Age-Associated Diseases; P. Puigserver and L. Guarente Mitochondrial Protein Acetylation and Sirtuin-Mediated Deacetylation; L. Valente, R. Szklarczyk, M. A. Huynen, and J. N. Spelbrink Mitochondrial Regulation by Protein Acetylation; D. B. Lombard, D. X. Tishkoff, and B. M. M. Zwaans Calorie Restriction, Mitochondria, and Longevity in Saccharomyces cerevisiae; C. Skinner and S.-J. Lin Autophagy and Aging: Keeping Organelles and the Proteome Healthy; J. L. Schneider and A. M. Cuervo  Neurodegeneration Mitochondrial Dynamics and Its Implications in Metabolic Dysregulation and Neurodegeneration; A. Zorzano, J. Segales, M. I. Hernandez-Alvarez, and E. Sorianello Mitochondrial Abnormalities and Oxidative Stress in Alzheimer's Disease: Can Mitochondrial Reactive Oxygen Species Signaling Promote Neuronal Survival? P. I. Moreira and C. R. Oliveira The Role of Mitochondria in Parkinson's Disease and Huntington's Disease; A. H. V. Schapira alpha-Ketoglutarate Dehydrogenase Complex in Neurodegeneration; G. E. Gibson, A. Starkov, Q. Shi, and M. Flint Beal R-alpha-Lipoic Acid as a Potent Agent of Mitochondrial Protection in Alzheimer's Disease; D. J. Bonda, M. A. Smith, G. Perry, H.-g. Lee, X. Wang, and X. Zhu Mitochondrial Antioxidants in Neuroprotection; G. Fiskum and M. D. Laird
 Abstract:             ''This book examines a unique assembly of coordinated mitochondrial functions that are important in regulating cell function and are of relevance in a myriad of pathophysiological situations, such as age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. The text covers themes essential for the maintenance of mitochondrial activity, including electron transport and energy production, mitochondrial biogenesis and dynamics, mitochondrial signaling, and apoptosis and autophagy. The book features chapters that are reviews of the important topics covered and are written by an impressive cadre of internationally recognized scientist''--Provided by publisher