Mitochondrial Biology and Experimental Therapeutics

Front Matter ....Pages i-ix
Front Matter ....Pages 1-1
 Introduction: Mitochondria, the Cell Furnaces  (Paulo J. Oliveira)....Pages 3-9
 Mitochondria: Where Are They Coming From?  (Mauro Degli Esposti)....Pages 11-17
 Mitochondrial Dynamics: A Journey from Mitochondrial Morphology to Mitochondrial Function and Quality  (David Sebastián, Antonio Zorzano)....Pages 19-31
 Mitochondria and Ageing  (Jose Viña, Consuelo Borras)....Pages 33-45
 The Mitochondrial Permeability Transition Pore  (Claudia Morganti, Massimo Bonora, Luigi Sbano, Giampaolo Morciano, Giorgio Aquila, Gianluca Campo et al.)....Pages 47-73
 Mitochondrial Regulation of Cell Death  (Dawei Liu, Jean-Luc Perfettini, Catherine Brenner)....Pages 75-90
 Mitochondria in Liver Diseases  (Ignazio Grattagliano, Ornella de Bari, Domenica Di Palo, Fabrizio Montecucco, Federico Carbone, Paulo J. Oliveira et al.)....Pages 91-126
 Mitochondria in Liver Regeneration: Energy Metabolism and Posthepatectomy Liver Dysfunction  (Henrique Alexandrino, Anabela Rolo, José Guilherme Tralhão, Francisco Castro e Sousa, Carlos Palmeira)....Pages 127-152
 Mitochondria Remodeling in Cancer  (Kenneth J. Dornfeld, Andrew J. Skildum)....Pages 153-191
 Mitochondria and Kidney Disease  (Kenneth E. McMartin)....Pages 193-211
 Role of Mitochondria in Neurodegenerative Diseases: The Dark Side of the “Energy Factory”  (Sónia C. Correia, Paula I. Moreira)....Pages 213-239
 Mitochondrial Disruption in Cardiovascular Diseases  (Edward J. Lesnefsky, Qun Chen, Bernard Tandler, Charles L. Hoppel)....Pages 241-267
 Drug-Induced Mitochondrial Toxicity  (Julie Massart, Annie Borgne-Sanchez, Bernard Fromenty)....Pages 269-295
 Potential Mechanisms of Mitochondrial DNA Mediated Acquired Mitochondrial Disease  (Afshan N. Malik, Hannah S. Rosa)....Pages 297-315
Front Matter ....Pages 317-317
 The Evolution of Mitochondrial Toxicity Assessment in Industry  (James Hynes, Yvonne Will)....Pages 319-332
 Targeting Mitochondria: The Road to Mitochondriotropic Antioxidants and Beyond  (Ricardo Amorim, Sofia Benfeito, José Teixeira, Fernando Cagide, Paulo J. Oliveira, Fernanda Borges)....Pages 333-358
 Recovering Mitochondrial Function in Patients’ Fibroblasts  (Mariusz R. Wieckowski, Alberto Danese, Giampaolo Morciano, Maciej Pronicki, Jerzy Duszynski, Paolo Pinton et al.)....Pages 359-378
 Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity  (Jorge Beleza, David Rizo-Roca, António Ascensão, José Magalhães)....Pages 379-406
 Modulation of Cell Fate by Tauroursodeoxycholic Acid: All Paths Lead to Mitochondria  (Susana Solá, Maria F. Ribeiro, Tânia Genebra, Cecília M. P. Rodrigues)....Pages 407-421
 Pharmacological Targeting of the Mitochondrial Permeability Transition Pore for Cardioprotection  (Filomena S. G. Silva, Cláudio F. Costa, Ricardo J. Marques, Paulo J. Oliveira, Gonçalo C. Pereira)....Pages 423-490
 Targeting the Mitochondrial Genome Through a Nanocarrier and the Regulation of Mitochondrial Gene Expression  (Yuma Yamada, Hideyoshi Harashima)....Pages 491-498
 Mitochondrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and Other Natural Supplements  (Garth L. Nicolson, Gonzalo Ferreira, Robert Settineri, Rita R. Ellithorpe, Paul Breeding, Michael E. Ash)....Pages 499-522
 Studies on Mitochondria Directed Plastoquinones  (Boris A. Feniouk, Vladimir P. Skulachev)....Pages 523-533
 Targeted Mitochondrial Genome Elimination  (Sandra R. Bacman, Claudia V. Pereira, Carlos T. Moraes)....Pages 535-563
 Targeting Therapeutic Nucleic Acids into Mitochondria: A Long Challenge  (Frédérique Weber-Lotfi, André Dietrich)....Pages 565-592
 Cell-Penetrating Peptides Targeting Mitochondria  (Carmine Pasquale Cerrato, Ülo Langel)....Pages 593-611
 Mitocans: Mitochondrially Targeted Anti-cancer Drugs  (Stepana Boukalova, Katerina Rohlenova, Jakub Rohlena, Jiri Neuzil)....Pages 613-635
 SkQ1: The Road from Laboratory Bench to the Market  (Boris A. Feniouk, Maxim V. Skulachev)....Pages 637-645
Front Matter ....Pages 647-647
 Mitochondrial Follies: A Short Journey in Life and Energy  (Anabela Marisa Azul, João Ramalho-Santos, Paulo Jorge Oliveira, Rui Tavares)....Pages 649-692
Back Matter ....Pages 693-708