Midkine: From Embryogenesis to Pathogenesis and Therapy

Front Matter....Pages i-ix
Front Matter....Pages 1-1
General Information on Midkine....Pages 3-13
The Role of Midkine in Neural Development and Patterning....Pages 15-28
Midkine: A Player in Innate Immunity....Pages 29-39
Midkine/P63 Axis in Regulation of Epithelial-Mesenchymal Transition....Pages 41-52
Immunochemical Methods for the Detection of Midkine in Samples of Human Origin....Pages 53-67
Circulating Midkine in Malignant, Inflammatory, and Infectious Diseases: A Systematic Review....Pages 69-85
Front Matter....Pages 87-87
Midkine in Inflammation and Inflammatory Diseases....Pages 89-101
Rheumatoid Arthritis and Midkine....Pages 103-109
Front Matter....Pages 111-111
Midkine and Heart Failure....Pages 113-124
Vascular Restenosis and Midkine....Pages 125-130
The Potential of MK Through the Renin-Angiotensin System....Pages 131-140
Front Matter....Pages 141-141
Midkine and Multiple Sclerosis....Pages 143-151
Midkine Gene Transfer in Brain Infarction....Pages 153-163
Midkine in Psychiatric and Neurodegenerative Diseases....Pages 165-170
Front Matter....Pages 171-171
Role of Midkine in Nephrogenesis and Kidney Disease....Pages 173-182
Midkine, a Factor Promoting Cytoplasmic Maturation of Oocytes....Pages 183-193
Endometriosis May Be Promoted by Midkine: Possible Involvement of Ovarian Follicles....Pages 195-202
Stem Cells and Midkine....Pages 203-210
Midkine in Skeletal Physiology....Pages 211-221
Front Matter....Pages 223-223
Midkine and Chemoresistance in Cancers....Pages 225-236
Front Matter....Pages 223-223
A Gene Medicine with the Midkine-mediated Transcriptional Regulation as New Cancer Therapeutics....Pages 237-246
Midkine as a Tumor-Shared Antigen....Pages 247-258
Midkine in Prostate Cancer....Pages 259-271
Midkine Is a Potential Therapeutic Target of Hepatocellular Carcinoma....Pages 273-282
Midkine in Glioblastoma with the Modulator Role Switching Autophagy to Cell Death or Cell Survival....Pages 283-303
Colon Cancer and Midkine....Pages 305-311
Osteosarcoma and Midkine....Pages 313-319
Back Matter....Pages 321-336