Microsurgical Models in Rats for Transplantation Research

Front Matter....Pages I-XIX
History and Development of Experimental Microsurgery in Rats....Pages 1-10
Reflections on the Requirements and Perspectives of a Microsurgical Research Group....Pages 11-18
Techniques of Microsurgical Vascular Anastomoses in Experimental Microsurgery....Pages 19-24
Heart Transplantation in Rats....Pages 25-30
Accessory Heart Transplantation in the Neck: A Simple Model in the Rat Using the Cuff Technique for Vascular Anastomoses....Pages 31-35
Microvascular Pulmonary Transplantation in Rats....Pages 37-42
Spleen and Vascularized Skin Flap Transplantation....Pages 43-46
Renal Transplantation in the Rat....Pages 47-50
Microsurgical Technique for Small-Intestine Transplantation....Pages 51-55
Various Techniques of Experimental Pancreas Transplantation in the Rat....Pages 57-63
Experiences in Rat Pancreatic Islet-Cell Isolation and Transplantation....Pages 65-68
Technique for Orthotopic Rat Liver Transplantation....Pages 69-75
Theoretical Aspects of Rat Organ Transplantation....Pages 77-81
Immunogenetic Aspects of Organ Transplantaion in the Rat....Pages 83-94
Venovenous Allotransplantation in the Rat....Pages 95-100
The Rejection Response to Segmental Grafts of the Femoral Artery in Inbred Rat Strains....Pages 101-105
Factors Influencing Endothelial-Cell Viability During Procurement and Preservation of Valve Allografts....Pages 107-111
The Rat Model as Precursor of Clinical Lymph Vessel Transplantation....Pages 113-116
Microstructure of Allogeneic Lymph Vessel Transplants in the Rat....Pages 117-120
Immunogenetic Basis of Heart Transplantation....Pages 121-126
Cyclosporin A in Heart Allografts in Rats....Pages 127-129
Monitoring of Rejection and Absorption Studies After Small-Bowel Transplantation in the Dog Model....Pages 131-134
Migration of Donor Passenger Cells During Rat Cardiac and Intestinal Allograft Rejection....Pages 135-144
Rejection and Graft Versus Host Reaction Following Small-Bowel Transplantation and Methods of Circumventing Them....Pages 145-152
Immunological Rections Induced by Graft Versus Host Rection Following Small-Bowel Transplantation....Pages 153-156
Combined Pancreas and Kidney Transplatation in the Rat....Pages 157-164
Immunological Characteristics of Vascularized Pancreas Transplantation....Pages 165-170
Is Preserved Exocrine Secretion Mandatory for Optimal Endocrine Function in Vascularized Pancreas Transplantation?....Pages 171-175
The Effect of Temporary Cyslosporin A Treatment on the Endocrine Function of Pancreaticoduodenal Allografts in the Rat....Pages 177-181
The Influence of Exocrine Secretion Management on Graft Survival in Different Pancreatic Transplant Models....Pages 183-188
Investigations of Glucose Tolerance Following Pancreatic Transplantation in Rats with Streptozotocin-Induced Diabetes....Pages 189-193
Successful Allotransplantation of Islets as Composite Graft in a Strong Rejection Model....Pages 195-197
The Immunogenicity of Pancreatic Islets....Pages 199-203
A New Approach to Experimental Pancreatic Islet Transplatation: Ultraviolet Irradiation....Pages 205-213
Characterization of Pancreas Islet-Cell Reactivity with Various Immune Sera....Pages 215-220
Heterotopic Auxiliary Liver Transplantation with Respect to Its Clinical Application....Pages 221-225
Accelerated But Not Hyperacute Rejection of Liver Allografts in Hypersensitized Rats....Pages 227-231
Orthotopic Versus Auxiliary Liver Transplantation....Pages 234-235
Fine-Needle Aspiration Cytology of Orthotopic Liver Allografts in Rats....Pages 237-243
Immunosuppressive Effects of Liver Grafts in the Rat....Pages 245-246
Graft Tolerance After Orthotopic Liver Transplantation in a Primarily Nontolerant Strain Combination Following Temporary Cyclosporin A Treatment....Pages 247-253
Liver Transplantation and Cyclosporin A Therapy: Induction of Tolerance in a Strong Rejection Combination....Pages 255-257
Study of the Cellular Immunity of Tolerance Induced by Liver Grafting in the Rat....Pages 259-261
Mechanisms of Tolerance in Rat Liver Transplantation....Pages 263-268
Decreased Graft Versus Host Reaction After Portal Venous Drainage of Spleen Grafts in Inbred Strains of Rats....Pages 269-272
Do Transplants with Venous Drainage into the Portal System Undergo Delayed Rejection?....Pages 273-274
Transplantation of Chimeric Organs: Implications for the Passenger-Cell Concept....Pages 275-280
Orthotopic Rat Renal Transplantation Using the Cuff Method....Pages 281-283
Effect of Cyclosporin on the Function of the Proximal Tubule and Loop of Henle in the Rat Kidney....Pages 285-290
Cyclosporin A Blood Levels in Rats After Different Modes of Administration....Pages 291-294
Orthotopic Transplantation of the Fallopian Tube, Ovary, and Segment of the Uterus in Inbred Rats....Pages 295-301
Allogeneic and Xenogeneic Biografts in Reconstructive Surgery of the Trachea....Pages 303-308
Immunological Mechanisms in Clinical Organ Transplantation....Pages 309-313
Immunohistological Analysis of Late Cellular Rejection and Cyclosporin-A-Resistant Acute Rejection in Human Kidney Allograft: Evidence of Delayed-Type Hypersensitivity Reaction Mechanisms....Pages 315-326
Immunological Monitoring of Heart Transplant Patients: Clinical and Experimental Studies....Pages 327-336
Intestinal Transplantation: Laboratory Experience and Clinical Consequencess....Pages 337-346
Experience with Segmental Pancreatic Transplantation in Stockholm....Pages 347-357
Clinical Experience in Islet Transplantation....Pages 359-367
Present Status of Clinical Liver Transplantation end Potential Developments Based on Experimental Microsurgical Models....Pages 369-377
Present Status of Clinical Kidney Transplantation and Possible Developments with Respect to Experimental Microsurgery Models....Pages 379-383
Conclusion....Pages 385-386
Back Matter....Pages 387-392