Microsomes and Drug Oxidations. Proceedings of the Third International Symposium, Berlin, July 1976

Content: 
Front Matter, Page iii
Copyright, Page iv
LIST OF PARTICIPANTS, Pages xv-xxvii
PREFACE, Page xxix, Volker Ullrich, Ivar Roots, Alfred G. Hildebrandt, Ronald W. Estabrook, Allan H. Conney
Inside Front Cover, Page xxxii
OTTO ROSENTHAL, THE MAN AND HIS WORK, Pages xxxi-xxxiv, Herbert Remmer
LIPID STRUCTURE OF LIVER MICROSOMAL MEMBRANES, LIMITATIONS OF A MODEL, Pages 1-8, A. Stier, W. Kühnle, R. Rösen
INTERACTIONS BETWEEN CYTOCHROME P-450 AND NADPH-CYTOCHROME P-450 REDUCTASE IN THE MICROSOMAL MEMBRANE, Pages 9-16, Chung S. Yang
A STUDY OF CYTOCHROME P-450 REDUCTION BY SODIUM DITHIONITE, Pages 17-22, Richard E. Ebel, David H. O'Keeffe, Julian A. Peterson
INVESTIGATION OF MICROSOMAL HYDROXYLATING SYSTEM AT SUB-ZERO TEMPERATURES, Pages 23-30, Pascale Debey, Monique Leon, Claude Balny, Pierre Douzou
ISOLATION OF MICROSOMAL ELECTRON TRANSPORT COMPONENTS AND RECONSTITUTION OF THE ELECTRON TRANSFER ACTIVITY ON LIPOSOMAL VESICLES, Pages 31-38, W. Duppel, J. Poensgen, V. Ullrich, G. Dahl
DIFFERENCES IN SUBSTRATE AFFINITY AND CATALYTIC SPECIFICITY OF INDUCIBLE AND NON-INDUCIBLE FORMS OF CYTOCHROME P-450 IN RABBIT LIVER, Pages 39-46, Tilman Fischbach, Werner Lenk
EFFECTS OF BUFFER COMPOSITION ON THE LOW-SPIN ESR SPECTRUM OF CYTOCHROME P-450, Pages 47-50, David H. O'Keeffe, Richard E. Ebel, Julian A. Peterson
KINETICS OF TIAMUTINR INTERACTION WITH CYTOCHROME P-450 FROM RABBIT LIVER, Pages 51-58, Ingeborg Schuster, Christine Fleschurz, Ilse Helm
DIFFERENT PHASES OF HYDROXYLASE INDUCTION IN LIVER MICROSOMES OF FEMALE MICE DURING INHALATION OF CYCLOHEXANE AND D,L-CAMPHOR, Pages 59-66, Gertrud Mohn
PROTEIN-LIPID INTERACTIONS IN THE LIVER MICROSOMAL HYDROXYLASE SYSTEM, Pages 67-75, Magnus Ingelman-Sundberg
FURTHER STUDIES OF THE FLUROXENE MEDIATED DESTRUCTION OF HEPATIC MICROSOMAL CYTOCHROMES P-450 IN VITRO, Pages 76-81, Kathryn M. Ivanetich, Julia A. Marsh, Jean J. Bradshaw, Laurence S. Kaminsky
PURIFICATION OF MEMBRANE-BOUND OXYGENASES: ISOLATION OF TWO ELECTROPHORETICALLY HOMOGENEOUS FORMS OF LIVER MICROSOMAL CYTOCHROME P-450, Pages 82-94, M.J. Coon, D.P. Ballou, D.A. Haugen, S.O. Krezoski, G.D. Nordblom, R.E. White
MICROSOMAL HEMEPROTEINS P-450LM-2 AND P-450LM-4:COMPARATIVE STRUCTURAL STUDIES, Pages 95-102, K. Dus, D. Carey, R. Goewert, R.A. Swanson
HEPATIC MICROSOMAL ETHANOL OXIDIZING SYSTEM: ISOLATION AND RECONSTITUTION, Pages 103-110, Rolf Teschke, Kunihiko Ohnishi, Yasushi Hasumura, Charles S. Lieber
CHARACTERIZATION OF NADPH-CYTOCHROME c(P-450) REDUCTASE PURIFIED BY BIOSPECIFIC AFFINITY CHROMATOGRAPHY UTILIZING SPECTROPHOTOMETRIC AND ELECTRON PARAMAGNETIC RESONANCE TECHNIQUES, Pages 111-118, Yukio Yasukochi, Julian A. Peterson, Bettie Sue Siler Masters
RELATIONSHIP BETWEEN THE MEMBRANE LIPIDS AND SUBSTRATE-CYTOCHROME P-450 BINDING REACTION IN BOVINE ADRENO-CORTICAL MICROSOMES, Pages 119-126, Shakunthala Narasimhulu
KINETIC AND SPECTRAL EVIDENCE FOR MULTIPLE SPECIES OF CYTOCHROME P-450 IN LIVER MICROSOMES, Pages 127-135, Garth Powis, Ronald E. Talcott, John B. Schenkman
DIFFERENCES IN THE INTERACTIONS OF R AND S WARFARIN WITH HEPATIC MICROSOMAL CYTOCHROME P-450, Pages 136-143, Michael J. Fasco, Lawrence J. Piper, Laurence S. Kaminsky
MULTIPLE FORMS OF HOUSEFLY CYTOCHROME P-450, Pages 144-151, Jorge Capdevila, Moises Agosin
CATALYTIC HYDROXYLATION ACTIVITIES AND SOME OTHER PROPERTIES OF PARTIALLY PURIFIED RABBIT PULMONARY MICROSOMAL CYTOCHROME P-450, Pages 152-159, Emel Arinç, Richard M. Philpot
HEPATIC MICROSOMAL AND SOLUBILIZED MIXED-FUNCTION OXIDASE SYSTEMS FROM THE LITTLE SKATE, Raja erinacea, A MARINE ELASMOBRANCH, Pages 160-169, John R. Bend, Roberta J. Pohl, Emel Arinç, Richard M. Philpot
AMINIMIDE POLYMERS AS SUPPORTS FOR AFFINITY CHROMATOGRAPHY, UNDER LOW AND HIGH PRESSURE, OF MICROSOMAL ENZYMES, Pages 170-176, J.C.M. Tsibris, J.E. Eppert, C.A. Ketchum, W.C. Sherrill, R.D. Safian, C.M. West
SEX DIFFERENCES IN THE PATTERN OF CYTOCHROMES P-450 IN RAT LIVER MICROSOMES, Pages 177-184, Regine Kahl, Michael Buecker, Karl Joachim Netter
CHARACTERIZATION OF MULTIPLE FORMS OF HIGHLY PURIFIED CYTOCHROME P-450 FROM THE LIVER MICROSOMES OF RATS, MICE AND RABBITS, Pages 185-191, W. Levin, D. Ryan, M.-T. Huang, J. Kawalek, P.E. Thomas, S.B. West, A.Y.H. Lu
THE MECHANISM OF CYTOCHROME P450 ACTION, Pages 192-201, V. Ullrich
OXYGEN REACTIONS OF THE P450 HEME PROTEIN, Pages 202-209, S.G. Sligar, B.S. Shastry, I.C. Gunsalus
THE PEROXIDASE NATURE OF CYTOCHROME P450, Pages 210-217, Anver D. Rahimtula, Peter J. O'Brien
CYTOCHROME P450 CATALYZED OXENE TRANSFER FROM VARIOUS DONORS, Pages 218-223, Fritz Lichtenberger, Volker Ullrich
ASSOCIATION ON TYPE I, TYPE II, AND REVERSE TYPE I DIFFERENCE SPECTRA WITH ABSOLUTE SPIN STATE OF CYTOCHROME P-450 IRON, Pages 224-231, Daniel W. Nebert, Kenji Kumaki, Mitsuo Sato, Hideo Kon
NMR RELAXATION TIME STUDIES OF SUBSTRATE INTERACTIONS WITH P450 AND OTHER HEMOPROTEINS, Pages 232-239, R.F. Novak, I.M. Kapetanovic, J.J. Mieyal
THE INTERACTION OF POLYHALOGENATED METHANES WITH FERROUS CYTOCHROME P450, Pages 240-246, C. Roland Wolf, Daniel Mansuy, Wolfgang Nastainczyk, Volker Ullrich
SUBSTRATE-ELICITED DISSOCIATION OF THE ISOSAFROLE METABOLITE-CYTOCHROME P-450 COMPLEX AND THE CONSEQUENTIAL REACTIVATION OF MONOOXYGENATION, Pages 247-253, Clifford R. Elcombe, Maurice Dickins, Brian C. Sweatman, James W. Bridges
THE INTERACTION OF HALOTHANE WITH LIVER MICROSOMAL CYTOCHROME P450, Pages 254-260, Wolfgang Nastainczyk, Volker Ullrich
THE FORMATION OF HYDROGEN PEROXIDE DURING HEPATIC MICROSOMAL ELECTRON TRANSPORT REACTIONS, Pages 261-268, Jurgen Werringloer
OXYGEN TRANSFER IN MICROSOMAL OXIDATIVE DESULFURATION, Pages 269-274, Hugo Kexel, Eike Schmelz, Hanns-Ludwig Schmidt
REDOX AND LIGAND DYNAMICS IN P450cam-PUTIDAREDOXIN COMPLEXES, Pages 275-283, T.C. Pederson, R.H. Austin, I.C. Gunsalus
THE INHIBITION OF MIXED-FUNCTION OXIDATION REACTIONS BY AMPHETAMINES IN LIVER AND LUNG MICROSOMES, Pages 284-291, Michael R. Franklin
THE PHYSIOLOGICAL IMPLICATIONS OF DRUG OXIDATIONS TO THE CELL, Pages 292-306, Sten Orrenius, Peter Moldéus, Hjördis Thor, Johan Högberg
NICOTINAMIDE NUCLEOTIDE SYSTEMS AND DRUG OXIDATION IN THE LIVER CELL, Pages 307-314, Helmut Sies, Klaus Weigl
THE ROLE OF REDUCING EQUIVALENTS GENERATED IN MITOCHONDRIA IN HEPATIC MIXED-FUNCTION OXIDATION, Pages 315-322, Ronald G. Thurman, Roxanne Evans, Marie Lurquin, Frederick C. Kauffman
DESTRUCTION OF CYTOCHROME P-450 BY LINOLEIC ACID HYDROPEROXIDE, Pages 323-330, E.H. Jeffery, D. Nerland, R. el-Azhary, G.J. Mannering
STOICHIOMETRY OF OXYGEN UPTAKE, NADPH OXIDATION AND ETHYLMORPHINE N-DEMETHYLATION BY HEPATIC MICROSOMES, Pages 331-338, Jordan L. Holtzman, Ronald P. Mason, Richard R. Erickson
STRUCTURAL AND FUNCTIONAL INTERACTION OF ROUGH ENDOPLASMIC RETICULUM (RER) AND MITOCHONDRIA DURING SYNTHESIS OF HEPATIC CYTOCHROME P450, Pages 339-345, Peter J. Meier, Max A. Spycher, Urs A. Meyer
MECHANISM OF N-OXIDE FORMATION BY HEPATIC MIXED FUNCTION OXIDASES, Pages 346-353, Peter Hlavica, Maria Kehl
A PRELIMINARY COMPARATIVE STUDY ON THE INFLUENCE OF CYSTEAMINE AND METYRAPONE ON MIXED-FUNCTION OXYGENASE ACTIVITIES IN VARIOUSLY PRETREATED LIVER MICROSOMES FROM RATS AND MICE, Pages 354-361, Robert Mull, Wolfgang Hinkelbein, Johannes Gertz, Kurt Flemming
INHIBITION OF RAT LIVER MICROSOMAL DT DIAPHORASE BY BENZO (a) PYRENE METABOLITE (S), Pages 362-369, Christina Lind, Lars Ernster
CHARACTERISTICS OF THE HEPATIC MONOOXYGENASE CATALYZING THE METABOLISM OF PROSTAGLANDIN A1 (PGA1) IN GUINEA PIGS AND RATS. I. EFFECTS OF INDUCERS, Pages 370-376, David Kupfer, Javier Navarro
STUDIES ON A CYTOCHROME P-450-DEPENDENT HYDROXYLASE SYSTEM ACTIVE ON STEROIDS IN Bacillus megaterium, Pages 377-384, Anders Berg, Kjell Carlström, Magnus Ingelman-Sundberg, Joseph Rafter, Jan-Åke Gustafsson
IMPACT OF DRUG MONOXYGENASES IN CLINICAL PHARMACOLOGY, Pages 385-394, A. Breckenridge, M.R. Bending, G. Brunner
THE ROLE OF LIVER NUCLEI IN THE FORMATION OF DNA BINDING PRODUCTS FROM BENZO(a) PYRENE, Pages 395-402, Bengt Jernström, Helena Vadi, Sten Orrenius
MECHANISM OF MICROSOMAL ACTIVATION OF BENZO[a] PYRENE TO DIOL-EPOXIDES: THE SEPARATION AND CHARACTERIZATION OF INTERMEDIATES AND PRODUCTS, Pages 403-410, Shen K. Yang, Harry V. Gelboin, Peter P. Roller
THE METABOLISM OF BENZO[a]PYRENE IN CELL CULTURES AND HOMOGENATES FROM DIFFERENT HUMAN FETAL TISSUES, Pages 411-417, Olavi Pelkonen, Pekka Korhonen
ARYL HYDROCARBON HYDROXYLASE IN CULTURED HUMAN LYMPHOCYTES, Pages 418-425, B. Paigen, H.L. Gurtoo, Jun Minowad, K. Paigen
ASSIGNMENT OF A HUMAN GENE FOR ARYL HYDROCARBON HYDROXYLASE EXPRESSION TO CHROMOSOME 2, Pages 426-434, F.J. Wiebel, S. Brown, J.D. Minna, H.V. Gelboin
OXIDATIVE METABOLISM OF CARCINOGENS BY TROUT LIVER RESULTING IN PROTEIN BINDING AND MUTAGENICITY, Pages 435-441, J. Ahokas, R. P¨äkkönen, K. Rönnholm, V. Raunio, N. Kärki, O. Pelkonen
DRUG-DRUG INTERACTIONS VIA INHIBITION OF MICROSOMAL ENZYMES INVOLVED IN METABOLISM OF EPOXIDES PRODUCED BY MICROSOMAL MONOOXYGENASE, Pages 442-446, F. Oesch, H.R. Glatt, P. Bentley
LEVELS OF GLUTATHIONE AND GLUTATHIONE-METABOLIZING ENZYMES IN RAT LUNG, Pages 447-452, Maria S. Moron, Joseph W. DePierre, Kerstin Jacobsson, Bengt Mannervik
THE DISPOSITION OF BENZO(A)PYRENE IN ISOLATED PERFUSED RAT LUNG, Pages 453-458, Kirsi Vähäkangas, Kaisu Nevasaari, Olavi Pelkonen, Niilo T. Kärki
EPOXIDE HYDRATASE IN RAT LUNG, Pages 459-466, Janeric Seidegård, Joseph W. DePierre, Maria S. Moron, Karin A.M. Johannesen, Lars Ernster
MONOOXYGENASE CATALYZED ACTIVATION OF THIONO-SULFUR CONTAINING COMPOUNDS TO REACTIVE INTERMEDIATES, Pages 467-475, R.A. Neal, T. Kamataki, A.L. Hunter, G. Catignani
STIMULATORY EFFECTS OF POLYCHLORINATED BIPHENYLS (PCB) ON CYTOCHROMES P-450 AND P-448 MEDIATED MICROSOMAL OXIDATIONS, Pages 476-483, Alvito P. Alvares
DEPRESSION OF HEPATIC CYTOCHROME P-450-DEPENDENT MONOOXYGENASE SYSTEMS WITH ADMINISTERED INTERFERON INDUCING AGENTS, Pages 484-491, Kenneth W. Renton, Gilbert J. Mannering
ALTERATIONS OF HEPATIC MICROSOMAL MIXED FUNCTION OXYGENASE DEPENDENT H2O2 FORMATION DUE TO “UNCOUPLING” AND INDUCTION AS DEMONSTRATED IN VIVO BY ELIMINATION KINETICS OF ETHANOL IN GUINEA PIG, Pages 492-499, A.G. Hildebrandt, L. Lehne, I. Roots, M. Tjoe
THE MICROSOMAL METABOLISM OF CARCINOGENIC AND/OR THERAPEUTIC HYDRAZINES, Pages 500-507, Russell A. Prough, Marguerite L. Coomes, Danny L. Dunn
ROLE OF HYDROXYLATED METABOLITES OF PHENYTOIN IN DOSE-DEPENDENCY, Pages 508-515, A.J. Glazko, T. Chang, E. Maschewske, A. Hayes, W.A. Dill
SPECIES DIFFERENCES IN DRUG METABOLISM; IN VIVO PARAMETERS OF HEPATIC DRUG-METABOLISING ENZYME ACTIVITY IN THE BABOON, Pages 516-519, W.H. Down
EVIDENCE FOR BINDING OF LIDOCAINE TO TWO CATALYTICALLY DIFFERENT SITES OF LIVER MICROSOMAL CYTOCHROME P-450, Pages 520-526, Christer von Bahr, Inger Hedlund, Bo Karlén, Hans Grasdalen
DIFFERENTIAL INFLUENCE OF PHYSIOLOGICAL, PHARMACOLOGICAL AND PATHOLOGICAL ALTERATIONS ON HEPATIC AND EXTRAHEPATIC DRUG METABOLISM, Pages 527-533, Theodore E. Gram, Branimir I. Sikic, Charles L. Litterst, E.G. Mimnaugh
METABOLISM OF HEXOBARBITAL ENANTIOMERS AND INTERACTION WITH CYTOCHROME P-450 IN MALE AND FEMALE MICE AND RATS, Pages 534-542, J. Noordhoek, A.P. Van Den Berg, E.M. Savenije-Chapel, E. Koopman-Kool
THE MECHANISM OF DEGRADATION OF ENDOGENOUS HEME AND CYTOCHROME P-450 BY HEME OXYGENASE, Pages 543-550, Mahin D. Maines
INDUCTION OF CYTOCHROME P-448 BY 3-METHYLCHOLANTHRENE IN THE RAT DURING INHIBITION OF PROTEIN SYNTHESIS IN VIVO, Pages 551-558, Georg F. Kahl, Bernd Zimmer, Teresa Galinsky, Hans G. Jonen, Regine Kahl
STIMULATION OF LIVER GROWTH AND MIXED-FUNCTION OXIDASE BY α-HEXACHLOROCYCLOHEXANE: SEPARATION OF INDUCTIVE PATHWAYS, Pages 559-567, Rolf Schulte-Hermann
INDUCTION OF CYTOCHROME P-450 BY LONG-TERM INFUSION OF PHENOBARBITAL, Pages 568-574, Otto Rosenthal, Harry M. Vars, Heinz Schleyer, David Y. Cooper, Sidney S. Levin, Joseph Touchstone
METABOLISM AND MUTAGENICITY OF 2-ACYLAMINOFLUORENES AND RELATED COMPOUNDS, Pages 575-580, Snorri S. Thorgeirsson, Peter J. Wirth, Wendel L. Nelson
IN VIVO PARAMETERS OF DRUG METABOLISM—DIFFERENCES IN SPECIFICITY TOWARDS INDUCING AGENTS, Pages 581-588, Ivar Roots, Beate Ley, Alfred G. Hildebrandt
STUDIES ON THE MECHANISM BY WHICH DISULFIRAM AND DIETHYLDITHIOCARBAMATE AFFECT DRUG METABOLISM, Pages 589-596, M. Marselos, P. Alakuijala, M. Lang, R. Törrönen
ALTERATIONS IN THE ACTIVITIES OF DRUG METABOLIZING ENZYMES IN RAT LIVER MICROSOMES BY DIETARY AND IN VITRO INCORPORATED CHOLESTEROL, Pages 597-604, Matti Lang, Osmo Hänninen
STEROID-16 α-HYDROXYLASE IN RAT LIVER: BIOCHEMICAL AND BIOLOGICAL PROPERTIES, Pages 605-609, Pierre Kremers, Ari Azhir-Amirsoleymanie, Jean De Graeve, Jacques E. Gielen
CORRELATION BETWEEN DRUG, LIPID AND CARBOHYDRATE METABOLISM IN THE RAT AFTER CHRONIC BETA-ADRENORECEPTOR ANTAGONIST TREATMENT, Pages 610-614, Erik Fellenius, Karl Olof Borg, Berit Eklund, Kurt-Jürgen Hoffmann, Britt-Marie Magnusson, Inger Skånberg, Marita Wallborg, Boel Wallin
CONVERSION OF TRICHLOROETHYLENE TO CARBON MONOXIDE BY MICROSOMAL CYTOCHROME P450, Pages 615-621, P.S. Traylor, W. Nastainczyk, V. Ullrich
STEREOSELECTIVE IN VITRO AROMATIC OXYGENATION OF CHIRAL 1,4-BENZODIAZEPIN-2-ONES, Pages 622-627, Slobodan Rendić, Vitomir Šunjić, Franjo Kajfež, Nikola Blažević
EFFECTS OF DISEASE STATES ON DRUG DISPOSITION IN MAN, Pages 628-645, Elliot S. Vesell
ISOLATION OF RAT LIVER EPOXIDE HYDRATASE: PROPERTIES AND SUBSTRATE SPECIFICITY OF THE PURE ENZYME, Pages 646-653, Philip Bentley, Franz Oesch
REDUCTION OF A TERTIARY AMINE N-OXIDE AND AN ARENE OXIDE IN RELATION TO THE REDUCTION RATE OF CYTOCHROME P-450 IN RAT LIVER MICROSOMES, Pages 654-660, Ryuichi Kato, Kazuhide Iwasaki, Hideyo Noguchi
MICROSOMAL OXIDATION OF ISOPROTERENOL AND IRREVERSIBLE PROTEIN BINDING OF METABOLITES, Pages 661-666, M. Scheulen, H. Kappus, H.M. Bolt
BENZO (α) PYRENE METABOLISM BY MICROSOMES AND ISOLATED EPITHELIAL CELLS FROM RAT SMALL INTESTINE, Pages 667-674, Roland Grafström, Sidney J. Stohs, M. Danny Burke, Peter Moldéus, Sten Orrenius
CHARACTERIZATION OF THE DRUG MONOOXYGENASE SYSTEM IN MOUSE SMALL INTESTINE, Pages 675-679, Peter Wollenberg, Volker Ullrich
FORMATION OF ALKYLATION AND CARBAMYLATION INTERMEDIATES AND CYTOCHROME P-450 CATALYZED MONOOXYGENATION OF THE 2-CHLOROETHYLNITROSOUREAS CCNU AND METHYL CCNU, Pages 680-687, Donald J. Reed, Hubert E. May
PROPOSED MECHANISM FOR THE REDUCTIVE GLYCOSIDIC CLEAVAGE OF DAUNOMYCIN (NSC 82151) AND ADRIAMYCIN (NSC 123127), Pages 688-697, David W. Yesair, Suzanne McNitt, Linda Bittman
COVALENT BINDING OF STYRENE OXIDE TO RAT LIVER MACROMOLECULES IN VIVO AND IN VITRO, Pages 698-702, Jukka Marniemi, Else-Maj Suolinna, Niilo Kaartinen, Harri Vainio
THE REGULATION OF HUMAN DRUG METABOLISM BY NUTRITIONAL FACTORS, Pages 703-708, A. Kappas, A.P. Alvares, K.E. Anderson, W.A. Garland, A.H. Conney, E.J. Pantuck
THE BAY-REGION THEORY: A QUANTUM MECHANICAL APPROACH TO AROMATIC HYDROCARBON-INDUCED CARCINOGENICITY, Pages 709-720, Donald M. Jerina, Roland E. Lehr
THE ACTIVATION AND INDUCTION OF BIPHENYL HYDROXYLATION AND CHEMICAL CARCINOGENESIS, Pages 721-729, Dennis V. Parke
INTEGRATED ELECTRON TRANSFER: IRON STATES AND REGULATION, Pages 730-734, I.C. Gunsalus
PURIFICATION OF LIVER MICROSOMAL CYTOCHROME P-450: HOPES AND PROMISES, Pages 735-747, W. Levin
ACTIVE OXYGEN—FACT OR FANCY, Pages 748-757, Ronald W. Estabrook, Jurgen Werringloer
INDEX, Pages 759-768