Microenvironmental Aspects of Immunity: Proceedings of the Fourth International Conference on Lymphatic Tissue and Germinal Centers in Immune Reactions held in Dubrovnik, Yugoslavia, June 26–30, 1972

Front Matter....Pages i-xxxii
Front Matter....Pages xxxiii-xxxiii
Structural Correlates of Immune Microenvironment....Pages 1-4
Front Matter....Pages 5-5
Introduction: Microenvironments in the Lymphoid System....Pages 7-10
Differentiation of B Lymphocytes from Stem Cell Precursors....Pages 11-18
Hemopoietic Origin of B Cells in the Mouse....Pages 19-26
Lymphocyte Differentiation in the Chicken Embryo — Relationship to the Microenvironment....Pages 27-33
The Lymphoid Development of the Embryonic Chicken Thymus in Organ Culture....Pages 35-41
Colonizing Capacity of Lymphoid Cells Injected into Syngeneic Hosts....Pages 43-48
Differential Traffic Patterns of T and B Lymphocytes in Relation to Germinal Centre Development....Pages 49-53
Ecotaxis of B Cells in the Mouse....Pages 55-62
Homing of B-Lymphocytes to Follicles: Specific Retention of Immunologically Committed Cells....Pages 63-70
Antigenic Markers on Lymphoid Cells Varying in their Capacity to Recirculate....Pages 71-77
Thymus Cell Migration: 3 HTDR-Labeled and Theta-Positive Cells in Peripheral Lymphoid Tissues of Newborn Mice....Pages 79-85
Lymph Node Function and Lymphocyte Circulation in the Pig....Pages 87-93
Germinal Centers: A Microenvironment for the Production of Antibody Forming Cell Precursors?....Pages 95-100
Microenvironmental Aspects of Lymphatic Tissue: Summary....Pages 101-103
Front Matter....Pages 105-105
Introduction: Cell Cooperation in Antibody Production — A Perspective with Questions....Pages 107-111
Functional Heterogeneity of Thymus-Derived Lymphocytes....Pages 113-118
Some Cell Surface Properties of Thymus-Derived Lymphocytes in Bursectomized Chickens....Pages 119-124
Studies on the Influence of T Cells in Antibody Responses of Mice to SIII and DNP-Lysine-SIII....Pages 125-131
Induction of Anti-Hapten Antibody Responses Against Haptens Conjugated to Autologous and Heterologous Proteins....Pages 133-139
Front Matter....Pages 105-105
Contribution of B and T Lymphocytes to in Vitro Chicken Proliferative Spleen Cell Reactions to Antigens....Pages 141-148
Proliferation of Activated Thymocytes in Mixed Lymphocyte Reactions....Pages 149-156
Lymphoid Cell Interactions in Cell-Mediated Immunity....Pages 157-166
Appendix and Thymus Cell Synergism in the Direct and Indirect Plaque Forming Cell Response to Sheep Erythrocytes in the Rabbit....Pages 167-170
The Role of Soluble Factors in T-B Cell Collaboration....Pages 171-178
Studies on the Source and Action of the T-Cell Replacing Factor (TRF)....Pages 179-182
Thymus Extracts Induce Differentiation of Thymus Derived Cells....Pages 183-189
Interaction of Lymphatic Cells: Summary....Pages 191-193
Front Matter....Pages 195-195
Introduction: Antigen Recognizing and Processing Cells....Pages 197-202
Immunoglobulin Surface Determinants on Chicken Lymphoid Cells....Pages 203-208
Functional and Morphologic Characteristics of Complement Receptor Lymphocytes in Mice....Pages 209-215
Stimulation of Mouse Thymocytes by Syngeneic Spleen Cells in Mixed Lymphocyte Reactions....Pages 217-223
Differential Induction and Suppression of Direct and Indidirect PFC Responses to TNP Conjugated to Heterologous Erythrocytes....Pages 225-232
Reconstitution of Primary Response in Vitro by Defined Peritoneal Cells....Pages 233-238
Uptake and Degradation of a Synthetic Antigen by Mouse Macrophages Containing Different Levels of Lysosomal Enzymes....Pages 239-245
Direct Evidence for Plaque Formation by Macrophages....Pages 247-253
The Proportion of Lymphocytes Capable of Recognizing Strong Transplantation Antigens in Vivo....Pages 255-262
Recovery of the Immune Response after Depletion of Specific Cells....Pages 263-268
Early Appearance of Antigen-Binding Cells to Two Different Antigens during Fetal Lymphoid Development....Pages 269-275
Antigen Recognizing and Processing Cells: Summary....Pages 277-279
Front Matter....Pages 281-281
Introduction: Cellular Aspects of Immune Deficiency Diseases Involving B Cells....Pages 283-287
Enhancement of the Immune Response of Genetically Thymus-Less Mice by Different Cell Populations....Pages 289-294
Thymus Factors and Immunity: Enhancement of Immunologic Maturation by a Purified Calf Thymus Extract....Pages 295-300
Involution of the Thymus Dependent Lymphoid System....Pages 301-306
A Study on Human T Lymphocytes, their Function and Frequency in Some Diseases....Pages 307-314
Evidence of Two Functionally Distinct Lymphocyte Populations in Man....Pages 315-320
The Relation between Nutritional Deprivation and Immunity....Pages 321-326
Combined System Immunodeficiency with Digeorge Syndrome and Dissociation of PHA/MLC Responses....Pages 327-336
Transplantation of Haemopoietic Stem Cell (HSC) Concentrates for Treatment of Immune Deficiency Disease....Pages 337-342
Immunological and Clinical Effects of Transfer Factor in Anergic Subjects....Pages 343-350
Cellular Aspects of Immune Deficiency Diseases: Summary....Pages 351-353
Front Matter....Pages 355-355
Introduction: Different Types of Immunological Unresponsiveness....Pages 357-362
Mechanism of Antigen Binding to Receptor Antibody in B Cell Immunity and Tolerance in Vitro ....Pages 363-368
Characteristics of B Cell Tolerance Induced with T-Independent Polysaccharides....Pages 369-375
Cortisone Interfering with the Production of “T and B cells”....Pages 377-382
Immunosuppression of the Thymectomized Fetal Lamb and its Neonatal Reconstitution....Pages 383-389
Antigen Recognition and Localization in Res Blockaded Mice: Morphologic and Immunologic Studies....Pages 391-398
The Effect of Cyclophosphamide on the Primary Humoral Immune Response. The Immunological Priming....Pages 399-405
Germinal Center in Rat Lymphatic Tissues after the Administration of L-Asparaginase....Pages 407-410
Enhancement of Tumour Growth by Lymphoid Cells from Mice Treated with Antilymphocyte Globulin....Pages 411-417
Front Matter....Pages 355-355
Role of the Spleen in Immunologic Enhancement of Kidney Grafts in Rats....Pages 419-425
Tolerance in Ovum Fusion Derived Tetraparental Mouse Chimaeras....Pages 427-434
Role of IgG 1 in Immunological Enhancement — Facilitation....Pages 435-442
Lymphatic Tissue in Tolerance, Immunosuppression and Facilitation: Summary....Pages 443-446
Front Matter....Pages 447-447
Introduction: Immune Reactions to Neoplastic Disease....Pages 449-454
Foetal Liver Stem Cells Inhibition by Ehrlich Ascites Carcinoma....Pages 455-460
Suppressed Plaque and Rosette-Formation by Spleen Cells of Mice Injected with Tumor Extracts....Pages 461-468
Immunosuppressive Factors Associated with Tumors....Pages 469-475
Effect of Therapy and Tumour Stage on Cellular Immunity to Bladder Carcinoma....Pages 477-482
Phase Specific Surface Autoantigens on Membranes of Fetus and Tumors....Pages 483-490
B Cell, T Cell and Monocyte Origin of the Guinea Pig L 2 C Leukemia, Mouse Lymphomas and Human Leukemias and Lymphoblastic Cell Lines....Pages 491-498
Immunocytes and Leukemia Virus Infection: Effects on Bone Marrow and Thymus Cell Responses and Interactions....Pages 499-505
Influence of the Lymphatic System on Development of a Virus-Induced Tumor (Reticuloendotheliosis) in the Chicken....Pages 507-512
Immune Reactions of the Syngeneic Host after the Intradermal Injection of Tumor Cells and Microsomes....Pages 513-518
Enhancement of Metastases by L-Asparaginase in Allogeneic and Isogeneic Mouse Tumor Systems....Pages 519-525
Reaction of Lymphatic Tissue in Neoplastic Disease: Summary....Pages 527-530
Front Matter....Pages 531-531
Introduction: Interaction between B and T Lymphocytes in Delayed Hypersensitivity....Pages 533-537
Contact Sensitivity in the Pig....Pages 539-544
The Effect of Lymphatic Interruption and Immediate Vascularization on the Afferent Arc of Skin Graft Rejection....Pages 545-551
Homograft Sensitivity in the Mouse: The Periodic Redistribution of Sensitised Lymphoid Cells....Pages 553-559
Front Matter....Pages 531-531
The Onset and Time-Course of Delayed-Type Hypersensitivity in Rats....Pages 561-566
Adjuvants and in Vitro Antibody Production....Pages 567-571
Basophilic Leukocytes in Delayed-Type Hypersensitivity Reactions in Experimental Animals and Man....Pages 573-579
Antibody and Cell Requirements for Cytotoxicity by Non-Immune Effector Cells....Pages 581-588
The Induction of a Cellular Immune Reaction against Self-Antigens Present in the Thymus....Pages 589-595
Germinal Center Formation in Response to Skin Grafted across Weak and Strong Histocompatibility (H 2 ) Barrier....Pages 597-602
Thymectomy and Bursectomy in Chickens with Simultaneous Experimental and Spontaneous Autoimmune Disease....Pages 603-609
Possible Role of Lymphokines in the Development of Ectopic Lymphoid Foci in the Chicken....Pages 611-618
Mediators of Cellular Hypersensitivity and Immunity Including Immunologically Specific Factors....Pages 619-626
Lymphatic Tissue in Immunopathology, with Special Reference to Delayed Hypersensitivity: Summary....Pages 627-630
Front Matter....Pages 631-631
Introduction: New Experimental Approaches....Pages 633-636
Manipulation of Fertilised Mouse Eggs Applied to Immunology....Pages 637-641
The Use of Germ-Free Piglets in the Study of Lymphoid Tissue and Germinal Centre Formation....Pages 643-649
Influence of Thymus on the Development of Endocrine and Immune Functions in Ontogeny....Pages 651-654
Hormones and Lymphoid Tissues. Contact Sensitivity and Detection of Theta-Cells in Pituitary Dwarf Mice....Pages 655-660
Immune Response and Lymphatic Tissue Reaction in Brain-Lesioned Rats....Pages 661-666
Stress and Hormonal Intervention in the Graft-Versus-Host Response....Pages 667-674
Antibody Responses in Cell Cultures from Draining and Non-Draining Rabbit Lymph Nodes Primed with Native or Polymerized Human Albumin....Pages 675-682
Changes in DNA Synthesis During Immunization in Mouse Spleen as Shown by Autoradiographs with Long Exposure Times....Pages 683-691
The Specific Separation of Enzyme Antigen-Binding Cells by Substrate Affinity Chromatography....Pages 693-698
Front Matter....Pages 631-631
New Experimental Approaches: Summary....Pages 699-701
Front Matter....Pages 703-703
Molecular Pharmacology of Cell-Mediated Immunity....Pages 705-711
Immuno-Embryology....Pages 713-718
Back Matter....Pages 719-726