Micro Total Analysis Systems 2000: Proceedings of the µTAS 2000 Symposium, held in Enschede, The Netherlands, 14–18 May 2000

Front Matter....Pages i-xix
Self-Assembled Monolayers with Chemical Functions....Pages 53-57
The Design of a Continuous Flow Combinatorial Screening Micro Reactor System with On-Chip Detection....Pages 59-62
Miniature Tools for Combinatorial Chemistry....Pages 63-66
Derivatization of Plastic Microfluidic Devices with Polyelectrolyte Multilayers....Pages 67-70
Flow-Through Chip Calorimeter Based on Bisb/Sb-Thin-Film Thermopiles with a Thermopower of 64 mV/K....Pages 71-74
Optimization of the Droplet Formation in a Piezo-Electric Flow-Through Microdispenser....Pages 75-78
A Multi-Nozzle Piezoelectric Microdispenser for Improving the Dynamic Volumetric Range of Droplets....Pages 79-82
A Microfluidic-Based Nanoscope....Pages 83-86
Design Analysis and 3D Measurement of Diffusive Broadening in a Y-mixer....Pages 87-90
Negative dielectrophoresis prevents surfaces from blocking....Pages 91-94
Microflow Analysis Based on Seqential and Bead Injection....Pages 1-10
Utilization of Bead Based Reagents in Microfluidic Systems....Pages 11-14
Analytical Devices Based on Transverse Transport in Microchannels....Pages 15-18
Airborne Chemistry for Biological Micro Analysis....Pages 19-24
Single Organelle Analysis with Integrated Chip Electrophoresis and Optical Tweezers....Pages 25-28
Separation of Target Microbe in Microchip by Flow Balancing and Visually Guided Laser Tele-Manipulator....Pages 29-32
Microreaction Technology for Process Intensification and High Throughput Screening....Pages 33-40
Micromachined Fluidic Couplers....Pages 41-44
In-Channel Processing to Create Autonomous Hydrogel Microvalves....Pages 45-48
Miniaturization and Integration of Photoacoustic Detection with a Microfabricated Chemical Reactor System....Pages 49-52
A Valve-Less Diffuser Micropump for Microfluidic Analytical Systems....Pages 95-98
Biosystem for the culture and characterisation of epithelial cell tissues....Pages 99-102
Somatic Cell Counting with Silicon Apertures....Pages 103-106
Microfabricated Fluidic Devices for Cellular Assays....Pages 107-110
Microbiology On-a-Chip....Pages 111-114
Dielectrophoretic separation/isolation of rare particles/cell types form a heterogeneous suspension within a microfluidic system....Pages 115-118
Immuno-Electrophoresis of Blood Cells on Micro-Capillary Chips....Pages 119-122
Realisation of a Cell Manipulation Bio-Microsystem using Shadow mask techniques....Pages 123-126
A Combined Dielectrophoretic and Field-Flow Fractionation Microsystem for Biomedical Separation and Analysis....Pages 127-130
Integrated Silicon Microheating Elements using Silicon-on-Plastic Drop-In Functionality....Pages 131-134
A μTAS — Atomic Emission Flame Spectrometer (AES)....Pages 135-138
Thermal Management and Surface Passivation of a Miniaturized PCR Device for Traditional Chinese Medicine....Pages 139-142
μ-CE Chip Fabricated by Moving Mask Deep X-ray Lithography Technology....Pages 143-146
Fabrication of Artificial Muscle Based Valves for Controlled Drug Delivery....Pages 147-150
Technology chain for polymer μ-TAS applications....Pages 151-154
Development of Methods for On-Line Chemical Detection with Liquid-Phase Microchemical Reactors Using Conventional and Unconventional Techniques....Pages 155-158
Polymer Micro-Structures: Prototyping, Low-cost Mass Fabrication and Analytical Applications....Pages 159-162
Integration of Micro-Optical Systems for Fluorescence Detection in µ TAS Applications....Pages 163-166
Micro machined gas chromatograph based on a plasma polymerised stationary phase....Pages 167-170
A Micromachined Electron Beam Ion Source....Pages 171-174
Finding a good hydrogel composition for hydrogel based microvalves....Pages 175-178
Bonding and Etching Techniques for Precision Fabrication of Reliable Microvalves....Pages 179-182
Bi-Directional Valve-Less Micropump Fabricated Using Deep Reactive Ion Etching....Pages 183-186
Diamond Microchip Capillary Chromatography of Proteins....Pages 187-190
Microchamber Array for Immunosensor Applications....Pages 191-194
The Decade’s Search for the Killer Ap in μ-TAS....Pages 195-204
Structurally Programmable Microfluidic Systems....Pages 205-208
Design and Simulation of Particles and Biomolecules Handling Micro Flow Cells with Three-Dimensional Sheath Flow....Pages 209-212
Microfabricated Intrachannel Electrical Contacts for Material Transport Control....Pages 213-216
Microfabrication Technology for Chemical and Biochemical Microprocessors....Pages 217-220
High Efficiency Separations on Microchip Devices....Pages 221-224
An Integrated Fritless Column for Planar Capillary Electrochromatography with Conventional Stationary Phases....Pages 225-228
Hand-Held Miniature Chemical Analysis System (μChemlab) for Detection of Trace Concentrations of Gas Phase Analytes....Pages 229-232
Commercializing Lab-on-a-Chip Technology....Pages 233-238
Centrifugal Microfluidics: Applications....Pages 239-242
Versatile, Adaptable and Programmable Microfluidic Platforms for DNA Diagnostics and Drug Discovery Assays....Pages 243-248
Integrated Cell Based Assays in Microfabricated Disposable CD Devices....Pages 249-252
Microvolume Assays with Confocal Detection Systems....Pages 253-260
Living Cells in Opto-Electrical Cages Characterisation Manipulation and Force Measurements....Pages 261-264
Microfabricated Multi-Frequency Particle Impedance Characterization System....Pages 265-268
Novel Separation Method on a Chip Using Capillary Electrophoresis in Combination with Dielectrophoresis....Pages 269-272
Flow Profiling in Microstructures with Micrometer Resolution....Pages 273-276
An Active Silicon Micromixer for μTAS Applications....Pages 277-282
The Effect of Particles on Performance of Fixed-Valve Micropumps....Pages 283-286
Designing Corner Compensation for Electrophoresis in Compact Geometries....Pages 287-290
Computer Simulations of Electrokinetic Sample Manipulations in Microfluidic Devices....Pages 291-294
Transport Number Mismatch Induced Stacking of Swept Sample Zones for Microchip-Based Sample Concentration....Pages 295-298
Passive Microfluidics — Ultra-Low-Cost Plastic Disposable Lab-on-a-Chips....Pages 299-302
Dispersion Studies of Pressure-Driven Flow in Deep-Reactive-Ion-Etched Microfluidic Channels....Pages 303-306
Combination of Sample Pre-Concentration and Capillary Electrophoresis On-Chip....Pages 307-310
Microfluidics in a Rotating CD....Pages 311-314
Defect-Oriented Testing of Microelectronic/Fluidic Systems....Pages 315-318
A Microfluidic Sedimentation Particulate Capture Device with Internal Degassing Membranes....Pages 319-322
Self-Aligning Microfluidic Interconnects with Low Dead Volume....Pages 323-326
Development and Characterization of a Generic Microfluidic Subsystem toward Portable Biochemical Detection....Pages 327-330
TiO 2 Surface Modifications for Light Modulated Control of Flow Velocity....Pages 331-334
Polymer Microfluidic Valves, Membranes and Coatings....Pages 335-338
Novel Designs for Electrokinetic Injection in μTAS....Pages 339-342
Non-Destructive Mixing, Concentration, Fractionation and Separation of μm-sized Particles in Liquid by Ultrasound....Pages 343-346
A Closed Loop Controlled Electrochemically Actuated Micro Dosing System for in Situ Sensor Calibration....Pages 347-350
Consequences of Opposing Electrokinetically and Pressure-Induced Flows in Microchannels of Varying Geometries....Pages 351-354
On-Chip Separation of Explosive Compounds — Divided Reservoirs to Improve Reproducibility and Minimize Buffer Depletion....Pages 355-358
Counter Current Electrophoretic Sample Preparation for Microscale Chemical Analysis....Pages 359-362
Luminol Chemiluminescence Systems for Metal Analysis by μTAS....Pages 363-366
Miniaturized Capillary Isoelectric Focusing (cIEF): Towards a Portable High-Speed Separation Method....Pages 367-370
Liquid/Liquid Extraction Systems Using Micro-Contactor Arrays....Pages 371-374
A Cyclic Capillary Electrophoresis Separator on Silicon Substrate with Synchronized-Switching....Pages 375-378
Microchip-Nano-Electrospray Device for Rapid On-Chip Digestion and Mass Spectrometric Analysis of Hemoglobin Variants....Pages 379-382
Capillary Electrophoresis with Direct and Contactless Conductivity Detection on a Polymer Microchip....Pages 383-386
Interfacing Protein and Peptide Separation to Maldi-TOF MS Using Microdispensing and on-Target Enrichment Strategies....Pages 387-390
Miniaturized Capillary Electrophoresis System with Integrated Conductivity Detector....Pages 391-394
Microfabricated CE Chips with Optical Slit for UV Absorption Detection....Pages 395-398
Blood and Protein Separations Using a Micromachined Electrical Field-Flow Fractionation (µ-EFFF) System....Pages 399-402
Glucose Measurement in Blood Serum Injected by Electroosmosis into Phospholipid Polymer Coated Microcapillary....Pages 403-406
Valveless, Sealed Microfluidic Device for Automated Heterogeneous Immunoassay: Design and Operational Considerations....Pages 407-410
On-Chip Packed Channel Separations....Pages 411-414
Novel Injection Schemes for Ultra-High Speed DNA Separations....Pages 415-418
Realization of a Prototype Industrial on-Line Sensing System for Ammonium Based on Micro System Technology: Results and Future Perspectives....Pages 419-422
An Integrated System for Gene Detection Using Cycling Probe Technology....Pages 423-426
Single Molecule Detection and Bead Trapping in Microstructures for Molecule Selection and DNA Degradation....Pages 427-430
Quantitative Design and Analysis of Single-Particle Dielectrophoretic Traps....Pages 431-434
Zona Pellucida Removal of Mammalian Embryos in a Microfluidic System....Pages 435-438
Molecular Processing of a Single DNA Inside Channels for Genome Analysis....Pages 439-442
New Micro Devices for Single Cell Analysis, Cell Sorting and Cloning-on-a-Chip: The Cytocon TM Instrument....Pages 443-446
Synthesis and Analysis of Chemical Components in Nanoscale....Pages 447-454
A Microsystem Platform Interfacing MALDI-TOF MS for High Speed Automated Protein Identification....Pages 455-458
High-Density Reagent Storage Arrays for High-Throughput Screening....Pages 459-462
Towards Organic Synthesis in Microfluidic Devices: Multicomponent Reactions for the Construction of Compound Libraries....Pages 463-465
Nanochip Technology for Single DNA Molecule Analysis and Human Genomic Polymorphism Analysis....Pages 467-472
Micromachined Flow-through Filter-Chamber for Solid Phase DNA Analysis....Pages 473-476
Parallel DNA Sequencing on Microfabricated Electrophoresis Chips....Pages 477-480
Formation and Active Mixing of Metered Nano/Picoliter Liquid Droplets in a Microfluidic Device....Pages 481-484
High Throughput Screening/Residue Analysis and High Speed Protein Digestion Using Miniaturized Membrane Reactors/Separator....Pages 485-488
High-Throughput Screening on Microchips....Pages 489-492
Multi Micro Reactors Consist of Individually Temperature Controlled Silicon Well Arrays Realizing Efficient Biochemical Reactions....Pages 493-496
Plastic Microchip Electrophoresis for Clinical Applications of DNA Analysis....Pages 497-500
DNA Preparation by using a DNA Chip....Pages 501-504
Thermal Gradient DNA Chip....Pages 505-508
Enzyme-Based Electrochemical Biosensor with DNA Array Chip....Pages 509-512
Integration of Immunosorbent Assay System into a Multichannel Microchip for Clinical Diagnoses....Pages 513-515
A Microbead Sieve and Polarographic Detection Cell for Immunoassays with a Modular Microfluidic Interconnect....Pages 517-520
High-Throughput SNP Scoring in a Disposable Microfabricated CD Device....Pages 521-524
Real-time PCR Analysis on Nucleic Acids Purified from Plasma Using a Silicon Chip....Pages 525-528
Examination of Dielectrophoretic Behavior of DNA as a Function of Frequency from 30 Hz to 1 MHz Using a Flexible Microfluidic Test Apparatus....Pages 529-532
Multichannel Microchip System for Rapid Calibration and Immunoassay....Pages 533-536
mRNA Isolation for cDNA Library Construction on a Chip....Pages 537-540
Sub-Microliter Assays and DNA Analysis on Plastic Microfluidics....Pages 541-544
A Miniaturized and Integrated Plastic Thermal Chemical Reactor for Genetic Analysis....Pages 545-548
Nanofabricated Device for Fluorescence Correlation Spectroscopy in Sub-Femtoliter Volumes....Pages 549-552
Protein Microarrays for Monitoring of Structural Changes of Proteins Via Surface Enhanced Metal NANO Cluster Resonance....Pages 553-556
Miniaturized Electrospraying as a Technique for the Production of Microarrays of Reproducible Micrometer Sized Protein Spots....Pages 557-560
Computational Simulation of Bio-Microfluidic Processes in Integrated DNA Biochips....Pages 561-564
A Centrifugal Microfluidic Platform — A Comparison....Pages 565-570
An AC Magnetohydrodynamic Microfluidic Switch....Pages 571-574
Hydrophobic Valves by Ink-Jet Printing on Plastic CDs with Integrated Microfluidics....Pages 575-578
Design Analyses of Capillary Burst Valves in Centrifugal Microfluidics....Pages 579-582
Electrokinetic Pump Application in Micro-Total Analysis Systems Mechanical Actuation to HPLC....Pages 583-590
An Atmospheric Pressure Plasma on a Chip Applied as a Molecular Emission Detector in Gas Chromatography....Pages 591-594
A Micro Viscosity Detector for a Planar Hydrodynamic Chromatography (HDC) System....Pages 595-598
Shear-driven Chromatography: The Route Towards Pressure Drop-Less Chromatographic Separations in Nanometric Channels....Pages 599-602
Shah Convolution Fourier Transform Detection....Pages 603-606
Macromolecular Crystallization Microarrayed Chip for Super Saturated Vapor and Liquid-Liquid Diffusion Screening....Pages 607-610
High Pressure Gas-Liquid Mixtures Generated in a Micro-Electrolysis Cell....Pages 611-614
Back Matter....Pages 615-623