Metallothionein IV

Front Matter....Pages I-XLVI
Front Matter....Pages 1-1
Nomenclature of metallothionein: Proposal for a revision....Pages 3-6
Metallothionein: Molecular evolution and classification....Pages 7-13
Structural and biological studies on native bovine Cu,Zn-metallothionein-3....Pages 15-21
Circular dichroism, emission, and exafs studies of Ag(I), Cd(II), Cu(I), and Hg(II) binding to metallothioneins and modeling the metal binding site....Pages 23-35
Metallothionein structure update....Pages 37-43
Simulation of Zn/Cd binding in mammalian metallothionein domains....Pages 45-49
The growth inhibitory activity of metallothionein-3 correlates with its novel β domain sequence rather than metal binding properties....Pages 51-54
Recombinant synthesis and metal-binding abilities of mouse metallothionein 1 and its α- and β-domains....Pages 55-61
Biochemical characterization of monomeric and dimeric cadmium-substituted metallothionein-3....Pages 63-69
Front Matter....Pages 71-71
Mammalian metallothionein sub-isoform separation by RP-HPLC with online UV and electrochemical detection....Pages 73-84
Characterisation of mammalian Cd, Zn metallothioneins using differential pulse polarography....Pages 85-91
Comparison of CZE and MECC separations of MT isoforms....Pages 93-97
Synthetic peptides and domains of metallothionein for structure function studies: rabbit liver peptide MT-IIA 49–61 and lobster MT β N β C and β C→N domains....Pages 99-109
Voltammetric methods in isolation and identification of plant metallothioneins from alga Chlorella ....Pages 111-115
Characterization of isometallothioneins in Chang liver cells and the transient accumulation of metallothionein and glutathione during cell proliferation....Pages 117-123
Quantification of cytosolic metallothionein contents by a developed assay system using immobilized antibody....Pages 125-128
Protein engineering of metallothionein to study the metal-binding ability....Pages 129-136
Metal binding proteins: Molecular engineering of improvements in metal specificity....Pages 137-143
Molecular splicing of metallothionein — study on domains of metallothionein....Pages 145-153
Front Matter....Pages 155-155
Involvement of metallothionein in female squirrelfish reproduction....Pages 157-165
Front Matter....Pages 155-155
Accumulation of untranslated metallothionein mRNA in antarctic hemoglobinless fish (icefish)....Pages 167-172
Structure and function of metallothionein isoforms in terrestrial snails....Pages 173-178
Functional and regulatory aspects of teleost metallothionein....Pages 179-185
Metallothionein induction in mussels exposed to a metal mixture....Pages 187-194
Synthesis and properties of class III metallothioneins of Schizosaccharomyces pombe in response to cadmium and zinc....Pages 195-199
Phytochelatins (class III metallothioneins) and their desglycyl peptides induced by cadmium in root cultures of Rubia tinctorum L.....Pages 201-205
Chemical and spectroscopic properties of copper metallothionein from the copper resistant fungus Beauveria bassiana ....Pages 207-212
Front Matter....Pages 213-213
Metallothionein facts and frustrations....Pages 215-221
Liver degeneration and embryonic lethality in mouse null mutants for the metal-responsive transcriptional activator MTF-1....Pages 223-226
New insights into the mechanisms of cadmium regulation of mouse metallothionein-I gene expression....Pages 227-232
Activation of mouse metallothionein I promoter by cadmium in human neuroblastoma cells....Pages 233-236
Transcription factors involved in heavy metal regulation of the human metallothionein-II A gene....Pages 237-241
Transcriptional regulation of the gene encoding mouse metallothionein-3 and its expression in the organs of the reproductive system....Pages 243-249
Dynamic regulation of yeast metallothionein gene transcription via metalloregulatory signaling factors....Pages 251-252
Metal regulation of mammalian metal responsive element (MRE) binding proteins....Pages 253-259
Metallothionein and hormone responsiveness....Pages 261-266
Synergistic activation of mouse metallothionein-I gene by interleukin-6 and glucocorticoid....Pages 267-272
Hammerhead ribozymes mediated down-regulation of rat metallothionein mrnas expression....Pages 273-280
Inactivation of metal-induced metallothionein gene expression by protein kinase C inhibitor....Pages 281-285
Cadmium-induced metallothionein expression and metallothionein mRNA in mice....Pages 287-288
Front Matter....Pages 289-289
The nuclear-cytoplasmic presence of metallothionein in cells during differentiation and development....Pages 291-294
Metallothionein and male genital organs....Pages 295-300
Induction of metallothionein-like cadmium binding protein in testis and its protective role against cadmium toxicity....Pages 301-307
Zinc homeostasis during pregnancy in metallothionein-null mice on a low zinc diet....Pages 309-313
Restriction of cadmium transfer to egg from laying hen exposed to cadmium: Involvement of metallothionein in the ovaries....Pages 315-320
Metallothionein expression during wool follicle development in foetal sheep....Pages 321-324
A role of hepatic metallothionein on mercury distribution in fetal guinea pigs after in utero exposure to mercury vapor....Pages 325-331
Cell differentiation alters metallothionein expression in avian growth plate chondrocytes....Pages 333-338
Front Matter....Pages 339-339
Metallothionein in oxidative stress of Parkinson’s disease....Pages 341-349
Metallothionein-1,2 and heme oxygenase-1 are expressed in damaged brain regions following chemically-induced seizures....Pages 351-357
Molecular cloning and expression of the metallothionein (MT)-I and MT-III in brain lesions of dogs....Pages 359-362
Liver and brain metallothionein regulation in transgenic mice overexpressing interleukin-6 and in mice carrying a null mutation in the interleukin-6 gene....Pages 363-370
Effects of capsaicin on metallothionein (MT) mRNA in sensory neurons: Possible role of MT-III in nociception....Pages 371-376
Metallothionein expression in the mammalian brain....Pages 377-382
Induction of metallothionein-I (MT-I) mRNA in primary astrocyte cultures is mediated by hypotonicity....Pages 383-387
Metallothionein in the cerebral cortex of rats showing hereditary high ability in sidman avoidance test....Pages 389-394
Front Matter....Pages 395-395
Roles of metallothionein in the cytotoxicity of copper in the liver of LEC rats....Pages 397-402
Fate of copper and metallothionein in the liver of LEC rats....Pages 403-412
Relationship between Cu metabolism hereditary disorders and distribution of Cu-metallothionein in kidneys....Pages 413-419
Zincsulphate protects from streptozotocin-induced diabetes mellitus in mice: A function of metallothionein?....Pages 421-428
Front Matter....Pages 395-395
MT does not protect endocrine cell damage induced by alloxan in pancreas of mice....Pages 429-431
Plasma MT levels in diabetic and renal failure patients....Pages 433-435
Metallothionein-mediated alterations in autoimmune disease processes....Pages 437-444
Dietary zinc, photoimmunosuppression and metallothionein (MT)....Pages 445-449
Front Matter....Pages 451-451
Metallothionein-null mice are susceptible to chronic CdCl 2 -induced nephropathy: Cd-induced renal injury is not necessarily mediated by CdMT....Pages 453-457
Cellular metallothionein: Properties of apometallothionein and the comparative toxicity of Cd 2+ and Cd-metallothionein....Pages 459-466
Zinc-induced protection against cadmium-metallothionein nephrotoxicity depends on glutathione status....Pages 467-469
Mechanism of improved cadmium-induced renal dysfunction after cessation of cadmium exposure....Pages 471-472
The role of metallothionein in cadmium-induced bone resorption....Pages 473-476
Metallothionein induction in human proximal tubular cell cultures — lack of protection against heavy metal toxicity....Pages 477-484
Relationship of metallothionein to cadmium and to zinc in human liver and kidney....Pages 485-488
Apoptosis of human kidney 293 cells is promoted by polymerized Cd-metallothionein....Pages 489-495
Front Matter....Pages 497-497
Subcellular localization mediated functioning of metallothionein: Protection against oxygen radicals and anticancer agents....Pages 499-503
Obesity and hyperleptinemia in a colony of metallothionein (-I and -II) null mice....Pages 505-510
Cardiac protection by metallothionein against ischemia-reperfusion injury and its possible relation to ischemic preconditioning....Pages 511-516
Metallothionein and its importance relative to glutathione in cardiac protection against doxorubicin toxicity....Pages 517-522
Metallothionein metal composition is a determinant of its induction of the mitochondrial permeability transition....Pages 523-527
Protective effect of metallothionein on DNA damage induced by hydrogen peroxide and ferric ion-nitrilotriacetic acid....Pages 529-534
Effect of metallothionein on cardiac reperfusion injury in rats....Pages 535-539
Susceptibility to metals and radical-inducing chemicals of metallothioneinnull mice....Pages 541-546
Front Matter....Pages 497-497
Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity....Pages 547-552
Effect of oxidative stress and bioavailable zinc on metallothionein in cultured human retinal pigment epithelial cells (RPE)....Pages 553-559
Specific binding sites of metallothionein on endothelium of small vessels in myocardium....Pages 561-566
Front Matter....Pages 567-567
Further studies on the role of metallothionein in the antitumor effects of cadmium....Pages 569-572
Effects of metallothionein expression on development of drug resistance....Pages 573-576
A chemical mechanism for inactivation of anticancer drugs by metallothionein....Pages 577-580
The possible role of metallothionein in cancer therapy by copper acetate....Pages 581-584
Interaction of metallothionein with the carcinogenic metals Ni(II), Cr(VI) and As(III)....Pages 585-594
A novel metallothionein gene therapy approach for chemo-and radio-protection....Pages 595-600
Metallothionein immunostaining as a prognostic indicator in canine mammary tumours....Pages 601-606
Metallothionein isoform gene expression in four human bladder cancer cell lines....Pages 607-612
The suppression of metallothionein synthesis inhibits the growth of leukemia P388 cells....Pages 613-617
Front Matter....Pages 619-619
Identification and characterisation of metallothioneins from environmental indicator species as potential biomonitors....Pages 621-627
Assessment of metal exposure of marine edible mussels by means of a biomarker....Pages 629-632
Metallothionein level estimation in the bioassay method for water quality assessment in freshwater reservoirs polluted by waste waters....Pages 633-640
Back Matter....Pages 641-650