Metallothionein II: Proceedings of the «Second International Meeting on Metallothionein and Other Low Molecular Weight Metalbinding Proteins», Zürich, August 21–24, 1985

Front Matter....Pages I-XII
Front Matter....Pages 1-1
Implications and Inferences of Metallothionein Structure....Pages 5-16
Nomenclature of Metallothionein....Pages 19-22
Chemistry and Biochemistry of Metallothionein....Pages 25-61
Molecular Biology of Metallothionein Gene Expression....Pages 63-80
Nutritional and Physiological Significance of Metallothionein....Pages 81-107
Toxicological Significance of Metallothionein....Pages 109-134
Front Matter....Pages 135-135
Crystal Structure of Cd,Zn Metallothionein....Pages 139-148
Spatial Structure of Rabbit Liver Metallothionein-2 in Solution by NMR....Pages 149-157
NMR Analysis of the Structure and Metal Sequestering Properties of Metallothioneins....Pages 159-169
Interprotein Metal Exchange Reactions of Metallothionein....Pages 171-178
Spectroscopic and Chemical Approaches to the Study of Metal-Thiolate Clusters in Metallothionein (MT)....Pages 179-189
Probing the Reactivity of the Zinc and Cadmium Ions Bound to Rabbit Liver Metallothioneins with EDTA....Pages 191-201
Information on Metal Binding Properties of Metallothioneins from Optical Spectroscopy....Pages 203-211
Copper Coordination in Metallothionein....Pages 213-218
Structral and Functional Aspects of Metal-Thiolate Centres in Metallothionein....Pages 219-226
EXAFS Studies of Metallothionein....Pages 227-236
Luminescence Emission from the Cu(I)-Thiolate Complex in Metallothioneins....Pages 237-241
Cadmium Binding and Metal Cluster Formation in Metallothionein: A Differential Modification Study....Pages 243-246
Metallothionein: A Bifunctional Chelator for the Radiolabeling of Biologically Active Molecules....Pages 247-253
Human Hepatic Metallothioneins: Resolution of Six Isoforms....Pages 257-264
Front Matter....Pages 135-135
Quantification and Characterization of Metallothioneins in Tissues of Lower Vertebrates and Invertebrates....Pages 265-272
Cadmium-Binding Proteins in Rat Testes: Characterization and Apparent Source of the Low-Molecular-Weight Protein....Pages 273-280
Low Molecular Weight Cadmium and Selenium Containing Proteins unlike Metallothionein in Animals....Pages 281-287
Characterization of Metallothionein-Like Protein in Rat Brain....Pages 289-291
Cadmium Resistance in Drosophila: A Small Cadmium Binding Substance....Pages 293-300
The Cd-Binding Protein from Tomato Compared to Those of other Vascular Plants....Pages 301-308
Purification and Characterization of Atypical Cadmium-Binding Polypeptides from Zea Mays....Pages 309-315
Phytochelatins, the Heavy Metal Binding Peptides of Plants: Characterization and Sequence Determination....Pages 317-322
Characterization of Metal Binding Peptides from Cadmium Resistant Plant Cells....Pages 323-327
Electrochemical Quantification and Characterization of Metallothioneins....Pages 329-333
Enzyme-Linked Immunosorbent Assay (ELISA) for Metallothionein....Pages 335-342
Comparison of Cadmium-Saturation Assay and Radioimmunoassay for the Determination of Metallothionein Concentration in Tissues....Pages 343-349
Metallothionein-Determination in Biological Materials: Interlaboratory Comparison of 5 Current Methods....Pages 351-358
Structure and Expression of the Human Metallothionein Genes....Pages 361-372
Rat Metallothionein Multigene Family....Pages 373-384
The Metallothionein Gene of Drosophila....Pages 385-392
Isolation and Regulation of Expression of the Neurospora Crassa Copper Metallothionein Gene....Pages 393-400
Transcriptional Control Mechanisms Which Regulate the Expression of Human Metallothionein Genes....Pages 401-405
Metal Regulatory Elements of the Mouse Metallothionein-I Gene....Pages 407-414
Inducible and Constitutive Sequence Elements in the Enhancer of the Mouse Metallothionein-I Gene....Pages 415-422
Front Matter....Pages 135-135
Function and Regulation of Yeast Copperthionein....Pages 423-429
Synaptic Relations in Meiotic Gene Conversion at the Iterated CUP1 r Locus of S. Cerevisiae ....Pages 431-437
Role of Metallothionein in Detoxification and Tolerance to Transition Metals....Pages 439-446
Molecular and Cellular Mechanisms of Cadmium Resistance in Cultured Cells....Pages 447-456
Analysis of the Detoxification of Heavy Metal Ions by Mouse Metallothionein....Pages 457-463
Heavy Metal Induced Protein Synthesis in Fish Cell Lines....Pages 465-469
Injection of the Mouse MT-1 Gene into Rainbow Trout Eggs and Assay of Trout Fry for Resistance to Cadmium and Zinc Toxicity....Pages 471-475
Abnormal Copper Metabolism and Regulation of Metallothionein Gene Expression in Menkes’ Disease....Pages 477-480
Metallothionein in Regeneration, Reproduction and Development....Pages 483-498
Biosynthesis and Metabolism of Metallothionein in Rat during Perinatal Development....Pages 499-505
Metallothionein in Blood, Bile and Urine....Pages 507-517
Metallothioneins of Monocytes and Lymphocytes....Pages 519-523
Synthesis and Degradation of Erythrocyte Metallothionein in Cadmium-Administered Mice....Pages 525-532
Histological Demonstration of Immunoreactive Metallothionein in Rat and Human Tissues....Pages 533-537
The Function of Metallothionein in Cell Metabolism....Pages 539-543
Regulation of Liver Zinc Metabolism and Metallothionein by Camp, Glucagon and Glucocorticoids and Suppression of Free Radicals by Zinc....Pages 545-553
The Involvement of Catecholamines and Polypeptide Hormones in the Multihormonal Modulation of Rat Hepatic Zinc Thionein Levels....Pages 555-563
Induction of Synthesis and Degradation of Metallothionein-I in the Tissues of Rats Injected with Zinc....Pages 565-572
Cadmium-Zinc Interactions in the Ehrlich Cell: Metallothionein and Other Sites....Pages 573-580
Effects of Type I Interferon-Inducing Agents on Hepatic Metallothionein....Pages 581-586
Front Matter....Pages 135-135
Metallothionein and Zinc Metabolism in Endotoxin Shock Rats....Pages 587-594
Protective Function of Metallothionein against Certain Anticancer Agents....Pages 595-602
Alteration of Radiosensitivity in Metallothionein Induced Mice and a Possible Role of Zn-Cu-Thionein in GSH-Peroxidase System....Pages 603-612
Activation of δ-Aminolevulinic Acid Dehydratase Following Donation of Zinc from Kidney Metallothionein....Pages 613-616
Role of Metallothionein in Induced Resistance to Cadmium Toxicity in Isolated Rat Hepatocytes....Pages 619-626
Metallothionein Gene Expression and Cadmium Toxicity in Freshwater Fish....Pages 627-630
Role of Metallothionein in Metal Detoxification and Metal Tolerance in Protein Calorie Malnutrition and Calcium Deficient Monkeys (Macaca mulatta)....Pages 631-638
Intestinal Absorption of Cadmium and Inorganic Mercury in the Rat: No Major Involvement of Metallothionein....Pages 639-646
Hepatic Lysosomal Copper-Thionein....Pages 647-653
Induction of Renal Metallothionein Allows Increasing Dose of an Extensively Used Antitumor Drug, cis -Diamminedichloroplatinum....Pages 655-660
Mechanism of Cadmium-Metallothionein-Induced Nephrotoxicity: Relationship to Altered Renal Calcium Metabolism....Pages 661-668
On the Role of Metallothionein in Cadmium Induced Renal Toxicity....Pages 669-675
Cadmium, Zinc and Copper in Rabbit Kidney Metallothionein — Relation to Kidney Toxicity....Pages 677-680
Front Matter....Pages 681-681
Program of the Second International Meeting on Metallothionein and Other Low Molecular Weight Metal-binding Proteins....Pages 683-694
Poster Abstracts....Pages 695-730
Back Matter....Pages 731-755