Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery

Setting the Scene....Pages 1-14
Front Matter....Pages 15-15
Genetics and Severe Sepsis....Pages 17-33
Cell Signaling Pathways of the Innate Immune System During Acute Inflammation....Pages 35-53
Early-Onset Pro-inflammatory Cytokines....Pages 55-66
The Significance of HMGB1, a Late-Acting Pro-inflammatory Cytokine....Pages 67-75
Nitric Oxide....Pages 77-95
Involvement of Reactive Oxygen and Nitrogen Species in the Pathogenesis of Acute Lung Injury....Pages 97-111
Heat Shock Proteins in Inflammation....Pages 113-121
Fibrosis in the Acute Respiratory Distress Syndrome....Pages 123-135
Resolution of Inflammation....Pages 137-157
Front Matter....Pages 159-159
Compartmentalized Activation of Immune Cells During Sepsis and Organ Dysfunction....Pages 161-182
The Neutrophil in the Pathogenesis of Multiple Organ Dysfunction Syndrome....Pages 183-201
The Role of the Macrophage....Pages 203-210
The Role of the Endothelium....Pages 211-227
Differential Effects of Pro-Inflammatory Mediators on Alveolar Epithelial Barrier Function....Pages 229-235
Front Matter....Pages 237-237
Macrocirculatory Disturbances....Pages 239-247
The Microcirculation Is a Vulnerable Organ in Sepsis....Pages 249-262
The Cholinergic Anti-inflammatory Pathway: Connecting the Mind and Body....Pages 263-272
Coagulation in Sepsis....Pages 273-285
The Role of Insulin and Blood Glucose Control....Pages 287-297
Front Matter....Pages 237-237
Dysfunction of the Bioenergetic Pathway....Pages 299-310
Metabolic Pathways....Pages 311-320
Cell Death and Acute Lung Injury....Pages 321-334
Mechanisms of Immunodepression after Central Nervous System Injury....Pages 335-350
Front Matter....Pages 351-351
Pulmonary Dysfunction....Pages 353-368
The Gut....Pages 369-381
Endogenous Danger Signals in Liver Injury: Role of High Mobility Group Box Protein-1....Pages 383-391
Sepsis-induced Acute Renal Failure and Recovery....Pages 393-405
Sepsis-Induced Brain Dysfunction....Pages 407-414
Myocardial Depression in Sepsis and Septic Shock....Pages 415-435
Skeletal Muscle....Pages 437-447