Mechanisms in Fibre Carcinogenesis

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Gaps in Knowledge of Fibre Carcinogenesis: An Epidemiologist’s View....Pages 3-15
Health Effects of Insulation Wools (Rock/Slag Wool and Glass Wool) and Future Research Needs....Pages 17-27
Non-Asbestos Fibre Burden in Individuals Exposed to Asbestos....Pages 29-37
Influence of Long-Lasting Asbestos Exposure on Immunological Status of Asbestos Exposed Shipyard Workers....Pages 39-42
Mesotheliomas in Man and Experimental Animals....Pages 45-49
Experimental Studies on Mineral Fibre Carcinogenesis: An Overview....Pages 51-58
The Relevance of Animal Bioassays to Assess Human Health Hazards to Inorganic Fibrous Materials....Pages 59-69
Relative Intrinsic Potency of Asbestos and Erionite Fibers: Proposed Mechanism of Action....Pages 71-80
Histopathological Analysis of Tumour Types after Intraperitoneal Injection of Mineral Fibres in Rats....Pages 81-89
Radiation-Induced Mesotheliomas in Rats....Pages 91-99
Front Matter....Pages 101-101
Carcinogenic Effect Related to the Fiber Physics and Chemistry....Pages 103-113
Fibre Size and Chemistry Effects in Vitro and in Vivo Compared....Pages 115-120
Inflammation and Immunomodulation Caused by Short and Long Amosite Asbestos Samples....Pages 121-130
Fiber Dimensions and Mesothelioma: A Reappraisal of the Stanton Hypothesis....Pages 131-141
Acute Pulmonary Effects of Inhaled Wollastonite Fibers are Dependent on Fiber Dimensions and Aerosol Concentrations....Pages 143-156
Toxicological Aspects of the Pathogenesis of Fiber-Induced Pulmonary Effects....Pages 157-179
Durability of Various Mineral Fibres in Rat Lungs....Pages 181-187
Health-Related Aspects of the Heating of Refractory Ceramic Fibre....Pages 189-197
Analysis of Polycyclic Aromatic Hydrocarbons on Vapor-Grown Carbon Fibers....Pages 199-212
Induction of Inflammation and Fibrosis after Exposure to Insoluble and Isometric Particles....Pages 213-228
Front Matter....Pages 101-101
Association of Tremolite Habit with Biological Potential: Preliminary Report....Pages 231-251
Distinguishing between Amphibole Asbestos Fibers and Elongate Cleavage Fragments of their Non-Asbestos Analogues....Pages 253-267
Asbestiform Minerals Associated with Chrysotile from the Western Alps (Piedmont - Italy): Chemical Characteristics and Possible Related Toxicity....Pages 269-283
Front Matter....Pages 285-285
Mechanisms of Fibre Genotoxicity....Pages 287-307
Asbestos Carcinogenicity: A Mutational Hypothesis....Pages 309-318
The Mutagenicity of Mineral Fibers....Pages 319-325
Chromosomal Damage and GAP Junctional Intercellular Communication in Mesothelioma Cell Lines and Cultured Human Primary Mesothelial Cells Treated with MMMF, Asbestos and Erionite....Pages 327-334
Chrysotile, Crocidolite, and Anthophyllite Facilitation of Transfection of Cultured Mouse Cells by Polyomavirus DNA....Pages 335-356
Asbestos Mediated Gene Expression in Rat Lung....Pages 359-365
Rat Pleural Cell Populations: Effects of MMMF Inhalation on Cytokine mRNA Expression and Population Characteristics....Pages 367-376
Growth Factor and Growth Factor Receptor Expression in Transformed Rat Mesothelial Cells....Pages 377-383
The Surface Activity of Mineral Dusts and the Process of Oxidative Stress....Pages 387-395
Iron Mobilization from Crocidolite Results in Enhanced Iron-Catalyzed Oxygen Consumption and Hydroxyl Radical Generation in the Presence of Cysteine....Pages 397-405
The Role of Iron in the Redox Surface Activity of Fibers. Relation to Carcinogenicity....Pages 407-414
Chemical Functionalities at the Broken Fibre Surface Relatable to Free Radicals Production....Pages 415-432
Reactive Oxygen Metabolite Production Induced by Mineral Fibres....Pages 433-438
Oxygen Consumption, Lipid Peroxidation and Mineral Fibres....Pages 439-446
Effects of Cigarette Smoke on Uptake of Asbestos Fibres by Tracheal Organ Cultures: The Role of Active Oxygen Species....Pages 447-455
Promoting Effects of Fibres. Fibres and the Second Messenger Pathways....Pages 459-467
Apparent Promotion by Chrysotile Asbestos of NHMI-Initiated Lung Tumours in the Rat....Pages 469-479
Front Matter....Pages 285-285
Effects of Amosite Asbestos Fibers on the Filaments Present in the Cytoskeleton of Primary Human Mesothelial Cells....Pages 481-490
A Comparison of the Occurrence and Distribution of Iron Deposits Caused by the Presence of Intrapleural Erionite and Crocidolite Fibres in Rats....Pages 491-497
Secretion of Interleukin 1 and Tumour Necrosis Factor by Alveolar Macrophages Following Exposure to Particulate and Fibrous Dusts....Pages 499-504
Cultured Human Mesothelial Cells are Selectively Sensitive to Cell Killing by Asbestos and Related Fibers: A Potential in Vitro Assay for Carcinogenicity....Pages 505-511
Front Matter....Pages 513-513
Animal and Cell Models for Understanding and Predicting Fibre-Related Mesothelioma in Man....Pages 515-530
Chronic Inhalation Toxicity of Refractory Ceramic Fibers in Syrian Hamsters....Pages 531-538
A Classification System for Non Asbestiform Fibres....Pages 539-545
Tumours by the Intraperitoneal and Intrapleural Routes and their Significance for the Classification of Mineral Fibres....Pages 547-565
Fibre Carcinogenesis: Intra-Cavitary Studies Cannot Assess Risk to Man....Pages 567-578
Back Matter....Pages 579-589