Mark's Basic Medical Biochemistry A Clinical Approach

Table of Contents......Page 1
Section One: Fuel Metabolism......Page 3
1: Metabolic Fuels and Dietary Components......Page 5
2: The Fed or Absorptive State......Page 24
3: Fasting......Page 32
Section Two: Chemical and Biological Foundations of Biochemistry......Page 41
4: Water, Acids, Bases, and Buffers......Page 43
5: Structures of the Major Compounds of the Body......Page 56
6: Amino Acids in Proteins......Page 74
7: Structure-Function Relationships in Proteins......Page 94
8: Enzymes as Catalysts......Page 117
9: Regulation of Enzymes......Page 140
10: Relationship between Cell Biology and Biochemistry......Page 159
11: Cell Signaling by Chemical Messengers......Page 186
Section Three: Gene Expression and Protein Synthesis......Page 207
12: Structure of the Nucleic Acids......Page 209
13: Synthesis of DNA......Page 224
14: Transcription: Synthesis of RNA......Page 239
15: Translation: Synthesis of Proteins......Page 260
16: Regulation of Gene Expression......Page 276
17: Use of Recombinant DNA Techniques in Medicine......Page 299
18: The Molecular Biology of Cancer......Page 319
Section Four: Oxidative Metabolism and the Generation of ATP......Page 339
19: Cellular Bioenergetics: ATP and O2......Page 343
20: Tricarboxylic Acid Cycle......Page 362
21: Oxidative Phosphorylation and Mitochondrial Function......Page 382
22: Generation of ATP from Glucose: Glycosis......Page 401
23: Oxidation of Fatty Acids and Ketone Bodies......Page 420
24: Oxygen Toxicity and Free Radical Damage......Page 441
25: Metabolism of Ethanol......Page 460
Section Five: Carbohydrate Metabolism......Page 475
26: Basic Concepts in the Regulation of Fuel Metabolism by Insulin,......Page 479
27: Digestion, Absorption, and Transport of Carbohydrates......Page 495
28: Formation and Degradation of Glycogen......Page 513
29: Pathways of Sugar Metabolism: Pentose Phosphate Pathway,......Page 529
30: Synthesis of Glycosides, Lactose, Glycoproteins, and Glycolipids......Page 544
31: Gluconeogenesis and Maintenance of Blood Glucose Levels......Page 558
Section Six: Lipid Metabolism......Page 581
32: Digestion and Transport of Dietary Lipids......Page 585
33: Synthesis of Fatty Acids, Triacylglycerols, and the Major Membrane......Page 596
34: Cholesterol Absorption, Synthesis, Metabolism, and Fate......Page 621
35: Metabolism of the Eicosanoids......Page 656
36: Integration of Carbohydrate and Lipid Metabolism......Page 670
Section Seven: Nitrogen Metabolism......Page 685
37: Protein Digestion and Amino Acid Absorption......Page 689
38: Fate of Amino Acid Nitrogen: Urea Cycle......Page 699
39: Synthesis and Degradation of Amino Acids......Page 714
40: Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine......Page 734
41: Purine and Pyrimidine Metabolism......Page 749
42: Intertissue Relationships in the Metabolism of Amino Acids......Page 764
Section Eight: Tissue Metabolism......Page 783
43: Actions of Hormones Regulating Fuel Metabolism......Page 785
44: The Biochemistry of the Erythrocyte and Other Blood Cells......Page 807
45: Blood Plasma Proteins, Coagulation and Fibrinolysis......Page 829
46: Liver Metabolism......Page 844
47: Metabolism of Muscle at Rest and During Exercise......Page 864
48: Metabolism of the Nervous System......Page 883
49: The Extracellular Matrix and Connective Tissue......Page 907