Marihuana: Chemistry, Biochemistry, and Cellular Effects

Front Matter....Pages i-xix
Front Matter....Pages 1-1
Cannabinoid Chemistry: An Overview....Pages 3-13
Detection and Identification of Compounds in Cannabis....Pages 15-30
Pyrolysis of Cannabinoids....Pages 31-38
Some Aspects of Cannabis Smoke Chemistry....Pages 39-49
Identification of Cannabinoids and Metabolites in Biological Materials by Combined Gas-Liquid Chromatography—Mass Spectrometry....Pages 51-62
Comparison of Various Solvent Extractions for the Chromatographic Analysis of Δ 9 -THC and Its Metabolites....Pages 63-69
Radioimmunoassay of Cannabis Products in Blood and Urine....Pages 71-85
Mass Fragmentographic Assays for the Cannabinoids and Their Metabolites....Pages 87-92
Examination of the Metabolites of Δ 1 -Tetrahydrocannabinol in Mouse Liver, Heart, and Lung by Combined Gas Chromatography and Mass Spectrometry....Pages 93-109
Identification and Quantification of Cannabinoids in Urine by Gallium Chelate Formation....Pages 111-121
Forensic, Metabolic, and Autoradiographic Studies of Δ 8 -and Δ 9 -Tetrahydrocannabinol....Pages 123-138
Cannabinoids: Metabolites Hydroxylated in the Pentyl Side Chain....Pages 141-157
Identification of Hydroxylated Cannabinoids by PMR and Mass Spectroscopy....Pages 159-168
Pharmacokinetics of Δ 9 -Tetrahydrocannabinol and Its Metabolites: Importance and Relationship in Developing Methods for Detecting Cannabis in Biologic Fluids....Pages 169-178
Rate of Penetration of Δ 9 -Tetrahydrocannabinol and 11-Hydroxy-Δ 9 -Tetrahydrocannabinol to the Brain of Mice....Pages 179-185
Changes in the Metabolism of Δ 9 -Tetrahydrocannabinol Caused by Other Cannabis Constituents....Pages 187-192
Front Matter....Pages 193-193
The Influence of Marihuana on Eukaryote Cell Growth and Development....Pages 195-205
Inhibition of Proliferation and Differentiation of Dictyostelium Discoideum Amoebae by Tetrahydrocannabinol and Cannabinol....Pages 207-211
Δ 9 -Tetrahydrocannabinol: Effect on Macromolecular Synthesis in Human and Other Mammalian Cells....Pages 213-222
 In Vitro Inhibition of Protein and Nucleic Acid Synthesis in Rat Testicular Tissue by Cannabinoids....Pages 223-241
Front Matter....Pages 193-193
Cytological and Cytochemical Effects of Whole Smoke and of the Gas Vapor Phase from Marihuana Cigarettes on Growth and DNA Metabolism of Cultured Mammalian Cells....Pages 243-256
Effects of Δ 8 -Tetrahydrocannabinol, Δ 9 -Tetrahydrocannabinol, and Crude Marihuana on Human Cells in Tissue Culture....Pages 257-263
Errors of Chromosome Segregation Induced by Olivetol, a Compound with the Structure of C-Ring Common to Cannabinoids: Formation of Bridges and Multipolar Divisions....Pages 265-271
Effect of Δ 1 -Tetrahydrocannabinol on Red Blood Cell Membranes and on Alveolar Macrophages....Pages 273-281
Cannabinoids: Effects on Lysosomes and Lymphocytes....Pages 283-298
Inhibitory Effects of Δ 9 -Tetrahydrocannabinol on Nucleic Acid Synthesis and Proteins in Cultured Lymphocytes....Pages 299-312
Cellular and Biochemical Alterations Induced in Vitro by Δ 1 -Tetrahydrocannabinol: Effects on Cell Proliferation, Nucleic Acids, Plasma Cell Membrane ATPase, and Adenylate Cyclase....Pages 313-327
Cannabinoids and Neoplastic Growth....Pages 329-345
A Comparison of the Subcellular Distribution of Cannabinoids in the Brains of Tolerant and Nontolerant Dogs, Rats, and Mice After Injecting Radiolabeled Δ 9 -Tetrahydrocannabinol....Pages 349-365
Sites of Neurochemical Action of Δ 9 -Tetrahydrocannabinol: Interaction with Reserpine....Pages 367-382
Effects of Δ 9 -Tetrahydrocannabinol on the Homosynaptic Depression in the Spinal Monosynaptic Pathway: Implications for Transmitter Dynamics in the Primary Afferents....Pages 383-395
Effects of Cannabinoids on Isolated Smooth Muscle Preparations....Pages 397-406
Effects of Δ 9 -Tetrahydrocannabinol and Cannabinol on Rat Brain Acetylcholine....Pages 407-413
Cannabinoids and the Inhibition of Prostaglandin Synthesis....Pages 415-424
Effects of Cannabinol Derivatives on Blood Pressure, Body Weight, Pituitary-Adrenal Function, and Mitochondrial Respiration in the Rat....Pages 425-438
The Immune Response and Marihuana....Pages 441-456
Teratologic Effects of Cannabis Extracts in Rabbits: A Preliminary Study....Pages 457-468
Alteration of Δ 9 -Tetrahydrocannabinol-Induced Prenatal Toxicity by Phenobarbital and SKF-525A....Pages 469-480
Pharmacogenetic Studies on Cannabis and Narcotics: Effects of Δ 1 -Tetrahydrocannabinol and Morphine in Developing Mice....Pages 481-494
Permanent Learning Impairment After Chronic Heavy Exposure to Cannabis or Ethanol in the Rat....Pages 495-505
Front Matter....Pages 193-193
Cannabis Sativa Derivatives: Effects on Brain Function of Monkeys....Pages 507-519
Marihuana’s Effects on Human Gonadal Function....Pages 521-532
Cellular Effects of Chronic Cannabis Use in Man....Pages 533-550
Concluding Summary....Pages 551-552
Back Matter....Pages 553-556