Managing Allergy

Cover Page......Page 1
Title: Managing Allergy......Page 2
ISBN 1846920256......Page 3
Contents (with page links)......Page 4
Editors and contributors......Page 6
PART I: Diagnosis......Page 9
Introduction......Page 11
What to accomplish by setting the diagnosis......Page 12
Establishing an allergy diagnosis......Page 13
Information on the IgE system......Page 15
Dose–response relationship between exposure to allergens and formation of sIgE......Page 16
Using sIgE results for risk assessment in patients with allergy......Page 18
The natural course of allergy development (Allergy March)......Page 22
Conclusion......Page 23
PART II: Allergic airway disease......Page 27
Introduction......Page 29
Time course of the increase in allergic disease and asthma......Page 30
Epidemiological evidence on the role of allergens in the development of asthma......Page 32
The cat paradox......Page 33
Severe asthma in adults......Page 35
Relevance to management of asthma......Page 36
Conclusions......Page 38
Introduction......Page 43
Fungi implicated......Page 44
Allergens......Page 45
Allergic bronchopulmonary aspergillosis (ABPA)......Page 46
Severe asthma with fungal sensitisation......Page 49
Occupational asthma and extrinsic allergic alveolitis caused by fungi......Page 51
Conclusion......Page 52
Introduction......Page 55
Is it rhinitis?......Page 56
Treatment of rhinitis......Page 60
Introduction......Page 73
Pathogenesis......Page 76
Natural history and epidemiology of asthma in CS......Page 80
Proposed mechanisms linking chronic sinusitis to asthma (Table 5.2)......Page 81
Clinical course......Page 84
Allergen avoidance / immunotherapy: the role of allergy in CHES......Page 85
Conclusion......Page 90
References......Page 91
PART III: Skin......Page 99
Introduction......Page 101
Irritant and allergic contact eczema (dermatitis)......Page 102
References......Page 114
Introduction......Page 119
Conclusion......Page 134
References......Page 135
PART IV: Systemic......Page 137
Introduction......Page 139
Background: what is latex and where does it come from?......Page 140
Latex allergens......Page 142
Relevant epidemiology......Page 143
References......Page 153
Introduction......Page 155
Conclusion......Page 162
References......Page 163
Introduction......Page 165
Food allergens......Page 168
Management of food allergy......Page 176
References......Page 179
Introduction......Page 187
Features of anaphylaxis......Page 189
References......Page 198
Introduction......Page 201
Site 2: Anti-IgE......Page 202
Site 3: Chromones......Page 204
Site 4: Anti-inf ammatory drugs—corticosteroids (glucocorticoids)......Page 206
Site 5: Antihistamines......Page 209
Site 6: Anti-leukotrienes—leukotriene receptor antagonists and synthesis inhibitors......Page 212
Site 7: Bronchodilators—β2-stimulants......Page 214
References......Page 215
Introduction......Page 221
Mechanisms......Page 222
SIT for venom anaphylaxis......Page 224
Effects of SIT on the natural history of allergic disease......Page 227
Safety......Page 228
Future directions......Page 229
Conclusion......Page 230
References......Page 231
Introduction......Page 233
How to achieve a major reduction in exposure......Page 234
Allergen avoidance in the treatment of allergic disease......Page 236
Environmental control in the prevention of allergic disease......Page 242
Conclusion......Page 244
References......Page 245
Introduction......Page 251
Anti-cytokine therapies......Page 252
Cytokine therapies......Page 257
PDE4 inhibitors......Page 258
Inhibition of intracellular signalling mechanisms......Page 259
Chemokine receptor antagonists......Page 260
Conclusion......Page 261
References......Page 262
What the future holds—on genes and environment......Page 265
What the future holds—the relevance of IgE antibody responses to different groups of allergens......Page 269
References......Page 272
Acronyms/ Abbreviations......Page 275
Index (with page links)......Page 279