Malignant Mesothelioma: Advances in Pathogenesis, Diagnosis, and Translational Therapies

Front Matter....Pages 1-1
The History of Mesothelioma....Pages 3-20
Asbestos-Induced Mesothelioma....Pages 21-33
SV40-Mediated Oncogenesis....Pages 34-59
Mesothelioma Carcinogenesis: In Vivo Models....Pages 60-86
Mesothelial and Mesothelioma Cell Lines....Pages 87-98
Front Matter....Pages 99-99
Cytogenetics of Malignant Mesothelioma....Pages 101-111
Growth Factors and Malignant Mesothelioma....Pages 112-123
Oncogenes and Tumor Suppressor Genes in Malignant Mesothelioma....Pages 124-140
Angiogenesis and Mesothelioma....Pages 141-150
Immune Status and Mesothelioma....Pages 151-165
Extracellular Matrix and Mesothelioma: Some Clues to the Invasive Behavior of Mesothelioma....Pages 166-185
Genomics and Proteomics in Mesothelioma....Pages 186-206
Front Matter....Pages 207-207
Asbestos Mineralogy and Health Effects....Pages 209-224
Molecular Epidemiology of Mesothelioma....Pages 225-241
Malignant Mesothelioma and Erionite....Pages 242-258
Determination of Asbestos Exposure by Pathology and Clinical History....Pages 259-266
Mesothelioma and Asbestos Exposure....Pages 267-292
From Monkey to Man: The Epidemiologic Evidence of an Association Between Simian Virus 40 and Malignancy....Pages 293-308
Causes and Prevention of Technical Artifacts When Studying Simian Virus 40 (SV40) in Human Mesotheliomas....Pages 309-329
Molecular Detection of Siman Virus 40 in Human Mesothelioma....Pages 330-349
Front Matter....Pages 207-207
Malignant Mesothelioma Following Radiation....Pages 350-363
Genetics and Human Mesothelioma....Pages 364-366
Front Matter....Pages 367-367
Clinicians’ Approach to Mesothelioma....Pages 369-379
Clinical Presentation and Natural History of Mesothelioma: Pleural and Pericardial....Pages 380-390
Clinical Presentation and Natural History of Mesothelioma: Abdominal....Pages 391-401
Staging of Mesothelioma....Pages 402-415
Prognostic Factors in Mesothelioma....Pages 416-429
Front Matter....Pages 431-431
Radiologic Assessment of Mesothelioma....Pages 433-453
Endoscopic Imaging....Pages 454-465
Front Matter....Pages 467-467
Benign Mesotheliomas, Mesothelial Proliferations, and Their Possible Association with Asbestos Exposure....Pages 469-480
Cytology of Malignant Mesothelioma....Pages 481-489
Immunohistochemistry....Pages 490-507
Malignant Mesothelioma Electron Microscopy....Pages 508-516
Rare Variants of Mesothelioma....Pages 517-526
Differentiating Sarcomas from Mesotheliomas....Pages 527-542
Diagnosis of Synovial Sarcoma of the Pleura and Differentiation from Malignant Mesothelioma....Pages 543-554
Pitfalls in the Diagnosis of Malignant Mesothelioma....Pages 555-578
Front Matter....Pages 579-579
Management of Benign Variants of Mesothelioma....Pages 581-592
First-Line Chemotherapy for Malignant Pleural Mesothelioma....Pages 593-606
Second-Line Chemotherapy....Pages 607-615
Front Matter....Pages 579-579
Treatment of Mesothelioma with Radiotherapy....Pages 616-627
Front Matter....Pages 629-629
Intrapleural Chemotherapy with and Without Surgery in Malignant Pleural Mesothelioma (MPM)....Pages 631-637
Management of Pleural Effusions in Mesothelioma....Pages 638-656
Preoperative Chemotherapy and Surgery....Pages 657-666
Photodynamic Therapy for Pleural Mesothelioma....Pages 667-677
Surgery and Postoperative Radiotherapy....Pages 678-695
The Development of the Brigham and Women’s Multimodality Treatment Plan for Malignant Pleural Mesothelioma: A Model for Improving the Treatment of Rare Diseases....Pages 696-722
Peritoneal Mesothelioma: The Columbia Experience....Pages 723-731
Surgery, Hyperthermic Chemoperfusion, and Postoperative Chemotherapy: The National Cancer Institute and Washington Hospital Center Experience....Pages 732-754
Pericardial and Tunica Vaginalis Mesothelioma....Pages 755-762
Front Matter....Pages 763-763
New Target Therapies for Malignant Mesothelioma....Pages 765-777
Gene Therapy for Malignant Pleural Mesothelioma....Pages 778-797
Immunotherapeutic Approaches and Vaccination Strategies....Pages 798-817
Front Matter....Pages 819-819
Economic Aspects of Mesothelioma....Pages 821-832