Major Histocompatibility Complex: Evolution, Structure, and Function

Front Matter....Pages ii-xxiii
Front Matter....Pages 1-1
Jaws and AIS....Pages 3-26
The MHC paralogous group: listing of members and a brief overview....Pages 27-44
The MHC « Big-Bang » : duplication and exon shuffling during chordate evolution. A hypothetico-deductive approach....Pages 45-52
Relationships among the genes encoding MHC molecules and the specific antigen receptors....Pages 53-65
Conserved linkage among sea urchin homologs of genes encoded in the vertebrate MHC region....Pages 66-74
Front Matter....Pages 75-75
Physical mapping of the class I regions of the rat major histocompatibility complex....Pages 77-90
MHC gene organization of the bony fish, medaka....Pages 91-109
Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes....Pages 110-130
Distribution of polypurine/polypyrimidine tract sequences in the human MHC region and their possible functions....Pages 131-145
Potential for paralogous mapping to simplify the genetics of diseases and functions associated with MHC haplotypes....Pages 146-157
Transposable elements and the metamerismatic evolution of the HLA class I region....Pages 158-177
Polymorphism in the HLA class I region....Pages 178-185
Nucleotide diversity within the human major histocompatibility complex: function of hitchhiking effect, duplications, indels and recombination....Pages 186-200
Front Matter....Pages 201-201
Proteasomes and MHC class I-peptide generation....Pages 203-212
Comparative aspects of the MHC class I-related MR1 , CD1D , and MIC genes in primates....Pages 213-221
Rat TL and CD1....Pages 222-235
Are chicken Rfp-Y class I genes classical or non-classical?....Pages 236-247
 Xenopus class I proteins....Pages 248-259
Two MHC class II A loci in the channel catfish....Pages 260-272
The evolution of MHC class I genes in cattle....Pages 273-278
Front Matter....Pages 201-201
Evidence for four functional DQA loci in cattle with distinct distributions amongst European and African populations....Pages 279-284
Front Matter....Pages 285-285
The NKC and regulation of natural killer cell-mediated immunity....Pages 287-301
Front Matter....Pages 303-303
Manipulation of MHC-encoded proteins by cytomegaloviruses....Pages 305-319
An animal model for understanding the immunogenetics of AIDS virus infection....Pages 320-326
Front Matter....Pages 327-327
Evolution of HLA-DRB loci, DRB1 lineages, and alleles: analyses of intron-1 and -2 sequences....Pages 329-346
The non-coding regions of HLA-DRB uncover inter-lineage recombinations as a mechanism of HLA diversification....Pages 347-353
Conversion or convergence? Introns of primate DRB genes tell the true story....Pages 354-376
Intron 1 sequence analysis of the MHC-DRB1, 3, 4, 5, and 6 genes in five non-human primate species....Pages 377-385
Evolution of Catarrhini DPB1 exon 2 under intragenic recombination....Pages 386-397
The effect of mutation, recombination and selection on HLA non-coding sequences....Pages 398-411
HLA-DQ haplotypes in 15 different populations....Pages 412-426
HLA class I and class II loci in Pacific/Asian populations....Pages 427-445
HLA class I alleles in Australian aborigines and their peptide binding profiles....Pages 446-462
An evolutionary overview of the MHC-G polymorphism: clues to the unknown function(s)....Pages 463-479
 MIC-A polymorphism and a MIC-A-MIC-B null haplotype with ~ 100-kb deletion....Pages 480-486
Repertoire forecast of MHC class I binding peptides with peptide libraries....Pages 487-502
Sequence conditions for gene conversion of mouse MHC genes....Pages 503-517
 Mhc class II genes of Darwin’s Finches: divergence by point mutations and reciprocal recombination....Pages 518-541
Contrasting patterns of MHC and microsatellite diversity in social and solitary tuco-tucos (Rodentia: Ctenomyidae)....Pages 542-554
Back Matter....Pages 555-561