Ma Vie en Noir: Fifty Years with Melatonin and the Stone of Madness

Front Matter....Pages i-xiii
Brief History of the Stone of Madness....Pages 1-8
The Prescientific Stage of the Pineal Gland....Pages 9-21
The Beginnings of the Pineal Scientific Era: From the Late Nineteenth Century to Melatonin’s Discovery....Pages 23-31
Sleep/Wake Cycle: History and Facts....Pages 33-51
When This Chronicler Enters the Story: The 1960s....Pages 53-60
The Stone of Madness as a Neuroendocrine Organ and Model: The 1970s....Pages 61-85
Peripheral Innervation of Neuroendocrine-Immune System: The Challenges to Change a Physiological Paradigm....Pages 87-113
Melatonin as a Potential Therapeutic Agent: The 1980s....Pages 115-130
Melatonin as a Chronobiotic That Opens the “Gates of Sleep”: The 1990s....Pages 131-154
Melatonin and the “Diseases of the Soul”: The Stone of Madness Returns....Pages 155-169
Twenty-First Century: The 24/7 Society as an Environmental Mutation....Pages 171-184
Melatonin as a Medicament for the 24/7 Society: Metabolic Syndrome....Pages 185-213
Melatonin as a Medicament for the 24/7 Society: Normal and Pathological Aging....Pages 215-243
Melatonin as a Medicament for the 24/7 Society: Cancer....Pages 245-281
Melatonin as a Nutraceutical....Pages 283-288
Back Matter....Pages 289-301